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MTF2 (metal response element binding transcription factor 2)

Identity

Alias_symbol (synonym)M96
PCL2
TDRD19A
Other aliasdJ976O13.2
HGNC (Hugo) MTF2
LocusID (NCBI) 22823
Atlas_Id 54476
Location 1p22.1  [Link to chromosome band 1p22]
Location_base_pair Starts at 93079235 and ends at 93139081 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
MTF2 (1p22.1) / ARL3 (10q24.32)MTF2 (1p22.1) / BRDT (1p22.1)MTF2 (1p22.1) / CTNND2 (5p15.2)
MTF2 (1p22.1) / GPSM2 (1p13.3)MTF2 (1p22.1) / RPL5 (1p22.1)MTF2 (1p22.1) / TSC22D1 (13q14.11)
MTF2 1p22.1 / BRDT 1p22.1MTF2 1p22.1 / CTNND2 5p15.2MTF2 1p22.1 / GPSM2 1p13.3
MTF2 1p22.1 / RPL5 1p22.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)MTF2   29535
Cards
Entrez_Gene (NCBI)MTF2  22823  metal response element binding transcription factor 2
AliasesM96; PCL2; TDRD19A; dJ976O13.2
GeneCards (Weizmann)MTF2
Ensembl hg19 (Hinxton)ENSG00000143033 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000143033 [Gene_View]  chr1:93079235-93139081 [Contig_View]  MTF2 [Vega]
ICGC DataPortalENSG00000143033
TCGA cBioPortalMTF2
AceView (NCBI)MTF2
Genatlas (Paris)MTF2
WikiGenes22823
SOURCE (Princeton)MTF2
Genetics Home Reference (NIH)MTF2
Genomic and cartography
GoldenPath hg38 (UCSC)MTF2  -     chr1:93079235-93139081 +  1p22.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MTF2  -     1p22.1   [Description]    (hg19-Feb_2009)
EnsemblMTF2 - 1p22.1 [CytoView hg19]  MTF2 - 1p22.1 [CytoView hg38]
Mapping of homologs : NCBIMTF2 [Mapview hg19]  MTF2 [Mapview hg38]
OMIM609882   
Gene and transcription
Genbank (Entrez)AF072814 AF073293 AF086050 AF086908 AJ010014
RefSeq transcript (Entrez)NM_001164391 NM_001164392 NM_001164393 NM_007358
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)MTF2
Cluster EST : UnigeneHs.31016 [ NCBI ]
CGAP (NCI)Hs.31016
Alternative Splicing GalleryENSG00000143033
Gene ExpressionMTF2 [ NCBI-GEO ]   MTF2 [ EBI - ARRAY_EXPRESS ]   MTF2 [ SEEK ]   MTF2 [ MEM ]
Gene Expression Viewer (FireBrowse)MTF2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)22823
GTEX Portal (Tissue expression)MTF2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9Y483   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9Y483  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9Y483
Splice isoforms : SwissVarQ9Y483
PhosPhoSitePlusQ9Y483
Domaine pattern : Prosite (Expaxy)ZF_PHD_1 (PS01359)    ZF_PHD_2 (PS50016)   
Domains : Interpro (EBI)Mtf2_C_dom    Tudor    Zinc_finger_PHD-type_CS    Znf_FYVE_PHD    Znf_PHD    Znf_PHD-finger    Znf_RING/FYVE/PHD   
Domain families : Pfam (Sanger)Mtf2_C (PF14061)    PHD (PF00628)   
Domain families : Pfam (NCBI)pfam14061    pfam00628   
Domain families : Smart (EMBL)PHD (SM00249)  TUDOR (SM00333)  
Conserved Domain (NCBI)MTF2
DMDM Disease mutations22823
Blocks (Seattle)MTF2
SuperfamilyQ9Y483
Human Protein AtlasENSG00000143033
Peptide AtlasQ9Y483
HPRD14342
IPIIPI00291983   IPI00216510   IPI00973456   IPI01009423   IPI00385159   IPI00644804   
Protein Interaction databases
DIP (DOE-UCLA)Q9Y483
IntAct (EBI)Q9Y483
FunCoupENSG00000143033
BioGRIDMTF2
STRING (EMBL)MTF2
ZODIACMTF2
Ontologies - Pathways
QuickGOQ9Y483
Ontology : AmiGOnegative regulation of transcription from RNA polymerase II promoter  DNA binding  nucleus  nucleoplasm  cytoplasm  segment specification  zinc ion binding  covalent chromatin modification  stem cell population maintenance  methylated histone binding  ESC/E(Z) complex  negative regulation of gene expression, epigenetic  positive regulation of transcription from RNA polymerase II promoter  stem cell differentiation  negative regulation of histone H3-K27 methylation  positive regulation of histone H3-K27 methylation  
Ontology : EGO-EBInegative regulation of transcription from RNA polymerase II promoter  DNA binding  nucleus  nucleoplasm  cytoplasm  segment specification  zinc ion binding  covalent chromatin modification  stem cell population maintenance  methylated histone binding  ESC/E(Z) complex  negative regulation of gene expression, epigenetic  positive regulation of transcription from RNA polymerase II promoter  stem cell differentiation  negative regulation of histone H3-K27 methylation  positive regulation of histone H3-K27 methylation  
NDEx NetworkMTF2
Atlas of Cancer Signalling NetworkMTF2
Wikipedia pathwaysMTF2
Orthology - Evolution
OrthoDB22823
GeneTree (enSembl)ENSG00000143033
Phylogenetic Trees/Animal Genes : TreeFamMTF2
HOVERGENQ9Y483
HOGENOMQ9Y483
Homologs : HomoloGeneMTF2
Homology/Alignments : Family Browser (UCSC)MTF2
Gene fusions - Rearrangements
Fusion : MitelmanMTF2/ARL3 [1p22.1/10q24.32]  
Fusion : MitelmanMTF2/BRDT [1p22.1/1p22.1]  [t(1;1)(p22;p22)]  
Fusion : MitelmanMTF2/CTNND2 [1p22.1/5p15.2]  [t(1;5)(p22;p15)]  
Fusion : MitelmanMTF2/GPSM2 [1p22.1/1p13.3]  [t(1;1)(p13;p22)]  
Fusion : MitelmanMTF2/RPL5 [1p22.1/1p22.1]  [t(1;1)(p22;p22)]  
Fusion: TCGAMTF2 1p22.1 BRDT 1p22.1 BRCA
Fusion: TCGAMTF2 1p22.1 CTNND2 5p15.2 LUSC
Fusion: TCGAMTF2 1p22.1 GPSM2 1p13.3 BRCA
Fusion: TCGAMTF2 1p22.1 RPL5 1p22.1 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMTF2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MTF2
dbVarMTF2
ClinVarMTF2
1000_GenomesMTF2 
Exome Variant ServerMTF2
ExAC (Exome Aggregation Consortium)MTF2 (select the gene name)
Genetic variants : HAPMAP22823
Genomic Variants (DGV)MTF2 [DGVbeta]
DECIPHERMTF2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMTF2 
Mutations
ICGC Data PortalMTF2 
TCGA Data PortalMTF2 
Broad Tumor PortalMTF2
OASIS PortalMTF2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMTF2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDMTF2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch MTF2
DgiDB (Drug Gene Interaction Database)MTF2
DoCM (Curated mutations)MTF2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MTF2 (select a term)
intoGenMTF2
Cancer3DMTF2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM609882   
Orphanet
MedgenMTF2
Genetic Testing Registry MTF2
NextProtQ9Y483 [Medical]
TSGene22823
GENETestsMTF2
Huge Navigator MTF2 [HugePedia]
snp3D : Map Gene to Disease22823
BioCentury BCIQMTF2
ClinGenMTF2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD22823
Chemical/Pharm GKB GenePA128394586
Clinical trialMTF2
Miscellaneous
canSAR (ICR)MTF2 (select the gene name)
Probes
Litterature
PubMed19 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMTF2
EVEXMTF2
GoPubMedMTF2
iHOPMTF2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri May 19 12:27:24 CEST 2017

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