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MTF2 (metal response element binding transcription factor 2)

Identity

Alias (NCBI)M96
PCL2
TDRD19A
dJ976O13.2
HGNC (Hugo) MTF2
HGNC Alias symbM96
PCL2
TDRD19A
HGNC Alias namepolycomb-like 2
 tudor domain containing 19A
LocusID (NCBI) 22823
Atlas_Id 54476
Location 1p22.1  [Link to chromosome band 1p22]
Location_base_pair Starts at 93079283 and ends at 93139076 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
MTF2 (1p22.1) / ARL3 (10q24.32)MTF2 (1p22.1) / BRDT (1p22.1)MTF2 (1p22.1) / CTNND2 (5p15.2)
MTF2 (1p22.1) / GPSM2 (1p13.3)MTF2 (1p22.1) / RPL5 (1p22.1)MTF2 (1p22.1) / TSC22D1 (13q14.11)
MTF2 1p22.1 / BRDT 1p22.1MTF2 1p22.1 / CTNND2 5p15.2MTF2 1p22.1 / GPSM2 1p13.3
MTF2 1p22.1 / RPL5 1p22.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)MTF2   29535
Cards
Entrez_Gene (NCBI)MTF2    metal response element binding transcription factor 2
AliasesM96; PCL2; TDRD19A; dJ976O13.2
GeneCards (Weizmann)MTF2
Ensembl hg19 (Hinxton)ENSG00000143033 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000143033 [Gene_View]  ENSG00000143033 [Sequence]  chr1:93079283-93139076 [Contig_View]  MTF2 [Vega]
ICGC DataPortalENSG00000143033
TCGA cBioPortalMTF2
AceView (NCBI)MTF2
Genatlas (Paris)MTF2
SOURCE (Princeton)MTF2
Genetics Home Reference (NIH)MTF2
Genomic and cartography
GoldenPath hg38 (UCSC)MTF2  -     chr1:93079283-93139076 +  1p22.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MTF2  -     1p22.1   [Description]    (hg19-Feb_2009)
GoldenPathMTF2 - 1p22.1 [CytoView hg19]  MTF2 - 1p22.1 [CytoView hg38]
ImmunoBaseENSG00000143033
Genome Data Viewer NCBIMTF2 [Mapview hg19]  
OMIM609882   
Gene and transcription
Genbank (Entrez)AF072814 AF073293 AF086050 AF086908 AJ010014
RefSeq transcript (Entrez)NM_001164391 NM_001164392 NM_001164393 NM_007358
Consensus coding sequences : CCDS (NCBI)MTF2
Gene ExpressionMTF2 [ NCBI-GEO ]   MTF2 [ EBI - ARRAY_EXPRESS ]   MTF2 [ SEEK ]   MTF2 [ MEM ]
Gene Expression Viewer (FireBrowse)MTF2 [ Firebrowse - Broad ]
GenevisibleExpression of MTF2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)22823
GTEX Portal (Tissue expression)MTF2
Human Protein AtlasENSG00000143033-MTF2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9Y483   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9Y483  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9Y483
PhosPhoSitePlusQ9Y483
Domaine pattern : Prosite (Expaxy)ZF_PHD_1 (PS01359)    ZF_PHD_2 (PS50016)   
Domains : Interpro (EBI)KDM4_Tudor_2    Mtf2_C_dom    MTF2_PHD1    MTF2_PHD2    Tudor    Zinc_finger_PHD-type_CS    Znf_FYVE_PHD    Znf_PHD    Znf_PHD-finger    Znf_RING/FYVE/PHD   
Domain families : Pfam (Sanger)Mtf2_C (PF14061)    PHD (PF00628)    Tudor_2 (PF18104)   
Domain families : Pfam (NCBI)pfam14061    pfam00628    pfam18104   
Domain families : Smart (EMBL)PHD (SM00249)  TUDOR (SM00333)  
Conserved Domain (NCBI)MTF2
PDB (RSDB)5XFR   
PDB Europe5XFR   
PDB (PDBSum)5XFR   
PDB (IMB)5XFR   
Structural Biology KnowledgeBase5XFR   
SCOP (Structural Classification of Proteins)5XFR   
CATH (Classification of proteins structures)5XFR   
SuperfamilyQ9Y483
AlphaFold pdb e-kbQ9Y483   
Human Protein Atlas [tissue]ENSG00000143033-MTF2 [tissue]
HPRD14342
Protein Interaction databases
DIP (DOE-UCLA)Q9Y483
IntAct (EBI)Q9Y483
BioGRIDMTF2
STRING (EMBL)MTF2
ZODIACMTF2
Ontologies - Pathways
QuickGOQ9Y483
Ontology : AmiGOnegative regulation of transcription by RNA polymerase II  RNA polymerase II transcription regulatory region sequence-specific DNA binding  transcription corepressor binding  DNA binding  chromatin binding  nucleus  nucleus  nucleoplasm  nucleoplasm  cytoplasm  focal adhesion  chromatin organization  regulation of transcription, DNA-templated  segment specification  stem cell population maintenance  methylated histone binding  methylated histone binding  negative regulation of gene expression, epigenetic  positive regulation of transcription by RNA polymerase II  metal ion binding  stem cell differentiation  negative regulation of histone H3-K27 methylation  positive regulation of histone H3-K27 methylation  cellular response to leukemia inhibitory factor  
Ontology : EGO-EBInegative regulation of transcription by RNA polymerase II  RNA polymerase II transcription regulatory region sequence-specific DNA binding  transcription corepressor binding  DNA binding  chromatin binding  nucleus  nucleus  nucleoplasm  nucleoplasm  cytoplasm  focal adhesion  chromatin organization  regulation of transcription, DNA-templated  segment specification  stem cell population maintenance  methylated histone binding  methylated histone binding  negative regulation of gene expression, epigenetic  positive regulation of transcription by RNA polymerase II  metal ion binding  stem cell differentiation  negative regulation of histone H3-K27 methylation  positive regulation of histone H3-K27 methylation  cellular response to leukemia inhibitory factor  
NDEx NetworkMTF2
Atlas of Cancer Signalling NetworkMTF2
Wikipedia pathwaysMTF2
Orthology - Evolution
OrthoDB22823
GeneTree (enSembl)ENSG00000143033
Phylogenetic Trees/Animal Genes : TreeFamMTF2
Homologs : HomoloGeneMTF2
Homology/Alignments : Family Browser (UCSC)MTF2
Gene fusions - Rearrangements
Fusion : MitelmanMTF2/ARL3 [1p22.1/10q24.32]  
Fusion : MitelmanMTF2/BRDT [1p22.1/1p22.1]  
Fusion : MitelmanMTF2/CTNND2 [1p22.1/5p15.2]  
Fusion : MitelmanMTF2/GPSM2 [1p22.1/1p13.3]  
Fusion : MitelmanMTF2/RPL5 [1p22.1/1p22.1]  
Fusion : QuiverMTF2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMTF2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MTF2
dbVarMTF2
ClinVarMTF2
MonarchMTF2
1000_GenomesMTF2 
Exome Variant ServerMTF2
GNOMAD BrowserENSG00000143033
Varsome BrowserMTF2
ACMGMTF2 variants
VarityQ9Y483
Genomic Variants (DGV)MTF2 [DGVbeta]
DECIPHERMTF2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMTF2 
Mutations
ICGC Data PortalMTF2 
TCGA Data PortalMTF2 
Broad Tumor PortalMTF2
OASIS PortalMTF2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMTF2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DMTF2
Mutations and Diseases : HGMDMTF2
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaMTF2
DgiDB (Drug Gene Interaction Database)MTF2
DoCM (Curated mutations)MTF2
CIViC (Clinical Interpretations of Variants in Cancer)MTF2
Cancer3DMTF2
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM609882   
Orphanet
DisGeNETMTF2
MedgenMTF2
Genetic Testing Registry MTF2
NextProtQ9Y483 [Medical]
GENETestsMTF2
Target ValidationMTF2
Huge Navigator MTF2 [HugePedia]
ClinGenMTF2
Clinical trials, drugs, therapy
MyCancerGenomeMTF2
Protein Interactions : CTDMTF2
Pharm GKB GenePA128394586
PharosQ9Y483
Clinical trialMTF2
Miscellaneous
canSAR (ICR)MTF2
HarmonizomeMTF2
DataMed IndexMTF2
Probes
Litterature
PubMed31 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXMTF2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:21:31 CEST 2021

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