Atlas of Genetics and Cytogenetics in Oncology and Haematology


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MTHFS (methenyltetrahydrofolate synthetase)

Identity

Alias_symbol (synonym)HsT19268
Other alias
HGNC (Hugo) MTHFS
LocusID (NCBI) 10588
Atlas_Id 70550
Location 15q25.1  [Link to chromosome band 15q25]
Location_base_pair Starts at 79843547 and ends at 79897285 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
BCR (22q11.23) / MTHFS (15q25.1)MTHFS (15q25.1) / ABCF1 (6p21.33)MTHFS (15q25.1) / BCL2A1 (15q25.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)MTHFS   7437
Cards
Entrez_Gene (NCBI)MTHFS  10588  methenyltetrahydrofolate synthetase
AliasesHsT19268
GeneCards (Weizmann)MTHFS
Ensembl hg19 (Hinxton) [Gene_View]
Ensembl hg38 (Hinxton) [Gene_View]  chr15:79843547-79897285 [Contig_View]  MTHFS [Vega]
TCGA cBioPortalMTHFS
AceView (NCBI)MTHFS
Genatlas (Paris)MTHFS
WikiGenes10588
SOURCE (Princeton)MTHFS
Genetics Home Reference (NIH)MTHFS
Genomic and cartography
GoldenPath hg38 (UCSC)MTHFS  -     chr15:79843547-79897285 -  15q25.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MTHFS  -     15q25.1   [Description]    (hg19-Feb_2009)
EnsemblMTHFS - 15q25.1 [CytoView hg19]  MTHFS - 15q25.1 [CytoView hg38]
Mapping of homologs : NCBIMTHFS [Mapview hg19]  MTHFS [Mapview hg38]
OMIM604197   
Gene and transcription
Genbank (Entrez)AK054972 AL109717 AL110101 BC012417 BC019921
RefSeq transcript (Entrez)NM_001199758 NM_006441
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)MTHFS
Cluster EST : UnigeneHs.459049 [ NCBI ]
CGAP (NCI)Hs.459049
Gene ExpressionMTHFS [ NCBI-GEO ]   MTHFS [ EBI - ARRAY_EXPRESS ]   MTHFS [ SEEK ]   MTHFS [ MEM ]
Gene Expression Viewer (FireBrowse)MTHFS [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10588
GTEX Portal (Tissue expression)MTHFS
Protein : pattern, domain, 3D structure
UniProt/SwissProtP49914   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP49914  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP49914
Splice isoforms : SwissVarP49914
Catalytic activity : Enzyme6.3.3.2 [ Enzyme-Expasy ]   6.3.3.26.3.3.2 [ IntEnz-EBI ]   6.3.3.2 [ BRENDA ]   6.3.3.2 [ KEGG ]   
PhosPhoSitePlusP49914
Domains : Interpro (EBI)FTHF_cligase    FTHF_cligase-like   
Domain families : Pfam (Sanger)5-FTHF_cyc-lig (PF01812)   
Domain families : Pfam (NCBI)pfam01812   
Conserved Domain (NCBI)MTHFS
DMDM Disease mutations10588
Blocks (Seattle)MTHFS
PDB (SRS)3HXT    3HY3    3HY4    3HY6   
PDB (PDBSum)3HXT    3HY3    3HY4    3HY6   
PDB (IMB)3HXT    3HY3    3HY4    3HY6   
PDB (RSDB)3HXT    3HY3    3HY4    3HY6   
Structural Biology KnowledgeBase3HXT    3HY3    3HY4    3HY6   
SCOP (Structural Classification of Proteins)3HXT    3HY3    3HY4    3HY6   
CATH (Classification of proteins structures)3HXT    3HY3    3HY4    3HY6   
SuperfamilyP49914
Peptide AtlasP49914
HPRD09174
IPIIPI00220567   IPI00797997   
Protein Interaction databases
DIP (DOE-UCLA)P49914
IntAct (EBI)P49914
BioGRIDMTHFS
STRING (EMBL)MTHFS
ZODIACMTHFS
Ontologies - Pathways
QuickGOP49914
Ontology : AmiGOATP binding  folic acid binding  cytoplasm  mitochondrial matrix  cytosol  cytosol  glutamate metabolic process  folic acid-containing compound biosynthetic process  formate metabolic process  5-formyltetrahydrofolate cyclo-ligase activity  5-formyltetrahydrofolate cyclo-ligase activity  5-formyltetrahydrofolate cyclo-ligase activity  5-formyltetrahydrofolate cyclo-ligase activity  tetrahydrofolate interconversion  tetrahydrofolate metabolic process  folic acid metabolic process  folic acid catabolic process  metal ion binding  
Ontology : EGO-EBIATP binding  folic acid binding  cytoplasm  mitochondrial matrix  cytosol  cytosol  glutamate metabolic process  folic acid-containing compound biosynthetic process  formate metabolic process  5-formyltetrahydrofolate cyclo-ligase activity  5-formyltetrahydrofolate cyclo-ligase activity  5-formyltetrahydrofolate cyclo-ligase activity  5-formyltetrahydrofolate cyclo-ligase activity  tetrahydrofolate interconversion  tetrahydrofolate metabolic process  folic acid metabolic process  folic acid catabolic process  metal ion binding  
Pathways : KEGGOne carbon pool by folate   
NDEx NetworkMTHFS
Atlas of Cancer Signalling NetworkMTHFS
Wikipedia pathwaysMTHFS
Orthology - Evolution
OrthoDB10588
Phylogenetic Trees/Animal Genes : TreeFamMTHFS
HOVERGENP49914
HOGENOMP49914
Homologs : HomoloGeneMTHFS
Homology/Alignments : Family Browser (UCSC)MTHFS
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMTHFS [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MTHFS
dbVarMTHFS
ClinVarMTHFS
1000_GenomesMTHFS 
Exome Variant ServerMTHFS
ExAC (Exome Aggregation Consortium)MTHFS (select the gene name)
Genetic variants : HAPMAP10588
Genomic Variants (DGV)MTHFS [DGVbeta]
DECIPHERMTHFS [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMTHFS 
Mutations
ICGC Data PortalMTHFS 
TCGA Data PortalMTHFS 
Broad Tumor PortalMTHFS
OASIS PortalMTHFS [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMTHFS  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDMTHFS
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch MTHFS
DgiDB (Drug Gene Interaction Database)MTHFS
DoCM (Curated mutations)MTHFS (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MTHFS (select a term)
intoGenMTHFS
Cancer3DMTHFS(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604197   
Orphanet
MedgenMTHFS
Genetic Testing Registry MTHFS
NextProtP49914 [Medical]
TSGene10588
GENETestsMTHFS
Huge Navigator MTHFS [HugePedia]
snp3D : Map Gene to Disease10588
BioCentury BCIQMTHFS
ClinGenMTHFS
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD10588
Chemical/Pharm GKB GenePA31239
Clinical trialMTHFS
Miscellaneous
canSAR (ICR)MTHFS (select the gene name)
Probes
Litterature
PubMed24 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMTHFS
EVEXMTHFS
GoPubMedMTHFS
iHOPMTHFS
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri May 19 11:44:08 CEST 2017

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