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MTIF2 (mitochondrial translational initiation factor 2)

Identity

Alias_symbol (synonym)IF-2mt
Other alias-
HGNC (Hugo) MTIF2
LocusID (NCBI) 4528
Atlas_Id 54477
Location 2p16.1  [Link to chromosome band 2p16]
Location_base_pair Starts at 55463756 and ends at 55496315 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
MTIF2 (2p16.1) / GLUL (1q25.3)MTIF2 (2p16.1) / MTIF2 (2p16.1)MTIF2 (2p16.1) / PLEKHH2 (2p21)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)MTIF2   7441
Cards
Entrez_Gene (NCBI)MTIF2  4528  mitochondrial translational initiation factor 2
Aliases
GeneCards (Weizmann)MTIF2
Ensembl hg19 (Hinxton)ENSG00000085760 [Gene_View]  chr2:55463756-55496315 [Contig_View]  MTIF2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000085760 [Gene_View]  chr2:55463756-55496315 [Contig_View]  MTIF2 [Vega]
ICGC DataPortalENSG00000085760
TCGA cBioPortalMTIF2
AceView (NCBI)MTIF2
Genatlas (Paris)MTIF2
WikiGenes4528
SOURCE (Princeton)MTIF2
Genetics Home Reference (NIH)MTIF2
Genomic and cartography
GoldenPath hg19 (UCSC)MTIF2  -     chr2:55463756-55496315 -  2p16.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)MTIF2  -     2p16.1   [Description]    (hg38-Dec_2013)
EnsemblMTIF2 - 2p16.1 [CytoView hg19]  MTIF2 - 2p16.1 [CytoView hg38]
Mapping of homologs : NCBIMTIF2 [Mapview hg19]  MTIF2 [Mapview hg38]
OMIM603766   
Gene and transcription
Genbank (Entrez)AF494407 AK225184 AK307993 BC002667 BC009845
RefSeq transcript (Entrez)NM_001005369 NM_001321001 NM_001321002 NM_001321003 NM_001321004 NM_001321005 NM_002453
RefSeq genomic (Entrez)NC_000002 NC_018913 NT_022184 NW_004929300
Consensus coding sequences : CCDS (NCBI)MTIF2
Cluster EST : UnigeneHs.149894 [ NCBI ]
CGAP (NCI)Hs.149894
Alternative Splicing GalleryENSG00000085760
Gene ExpressionMTIF2 [ NCBI-GEO ]   MTIF2 [ EBI - ARRAY_EXPRESS ]   MTIF2 [ SEEK ]   MTIF2 [ MEM ]
Gene Expression Viewer (FireBrowse)MTIF2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4528
GTEX Portal (Tissue expression)MTIF2
Protein : pattern, domain, 3D structure
UniProt/SwissProtP46199   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP46199  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP46199
Splice isoforms : SwissVarP46199
PhosPhoSitePlusP46199
Domaine pattern : Prosite (Expaxy)G_TR_2 (PS51722)    IF2 (PS01176)   
Domains : Interpro (EBI)P-loop_NTPase    Small_GTP-bd_dom    TF_GTP-bd_dom    TF_IF2_bacterial-like    TIF_IF2_dom3    Transl_B-barrel   
Domain families : Pfam (Sanger)IF-2 (PF11987)   
Domain families : Pfam (NCBI)pfam11987   
Conserved Domain (NCBI)MTIF2
DMDM Disease mutations4528
Blocks (Seattle)MTIF2
SuperfamilyP46199
Human Protein AtlasENSG00000085760
Peptide AtlasP46199
HPRD04792
IPIIPI00005039   IPI00893874   IPI00893794   IPI00893372   IPI00894045   IPI00893635   IPI00894272   IPI00892707   
Protein Interaction databases
DIP (DOE-UCLA)P46199
IntAct (EBI)P46199
FunCoupENSG00000085760
BioGRIDMTIF2
STRING (EMBL)MTIF2
ZODIACMTIF2
Ontologies - Pathways
QuickGOP46199
Ontology : AmiGOtranslation initiation factor activity  GTPase activity  GTP binding  nucleoplasm  mitochondrion  mitochondrion  regulation of translational initiation  translation factor activity, RNA binding  ribosome disassembly  ribosomal small subunit binding  poly(A) RNA binding  mitochondrial translational initiation  mitochondrial translational initiation  
Ontology : EGO-EBItranslation initiation factor activity  GTPase activity  GTP binding  nucleoplasm  mitochondrion  mitochondrion  regulation of translational initiation  translation factor activity, RNA binding  ribosome disassembly  ribosomal small subunit binding  poly(A) RNA binding  mitochondrial translational initiation  mitochondrial translational initiation  
NDEx NetworkMTIF2
Atlas of Cancer Signalling NetworkMTIF2
Wikipedia pathwaysMTIF2
Orthology - Evolution
OrthoDB4528
GeneTree (enSembl)ENSG00000085760
Phylogenetic Trees/Animal Genes : TreeFamMTIF2
HOVERGENP46199
HOGENOMP46199
Homologs : HomoloGeneMTIF2
Homology/Alignments : Family Browser (UCSC)MTIF2
Gene fusions - Rearrangements
Fusion : MitelmanMTIF2/PLEKHH2 [2p16.1/2p21]  
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMTIF2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MTIF2
dbVarMTIF2
ClinVarMTIF2
1000_GenomesMTIF2 
Exome Variant ServerMTIF2
ExAC (Exome Aggregation Consortium)MTIF2 (select the gene name)
Genetic variants : HAPMAP4528
Genomic Variants (DGV)MTIF2 [DGVbeta]
DECIPHER (Syndromes)2:55463756-55496315  ENSG00000085760
CONAN: Copy Number AnalysisMTIF2 
Mutations
ICGC Data PortalMTIF2 
TCGA Data PortalMTIF2 
Broad Tumor PortalMTIF2
OASIS PortalMTIF2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMTIF2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDMTIF2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch MTIF2
DgiDB (Drug Gene Interaction Database)MTIF2
DoCM (Curated mutations)MTIF2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MTIF2 (select a term)
intoGenMTIF2
Cancer3DMTIF2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603766   
Orphanet
MedgenMTIF2
Genetic Testing Registry MTIF2
NextProtP46199 [Medical]
TSGene4528
GENETestsMTIF2
Huge Navigator MTIF2 [HugePedia]
snp3D : Map Gene to Disease4528
BioCentury BCIQMTIF2
ClinGenMTIF2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD4528
Chemical/Pharm GKB GenePA31243
Clinical trialMTIF2
Miscellaneous
canSAR (ICR)MTIF2 (select the gene name)
Probes
Litterature
PubMed21 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMTIF2
EVEXMTIF2
GoPubMedMTIF2
iHOPMTIF2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Mar 30 15:11:14 CEST 2017

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