MTNR1A (melatonin receptor 1A)

2007-02-01 Affiliation

Identity

HGNC

MTNR1A

LOCATION

4q35.2

LOCUSID

4543

ALIAS

MEL-1A-R,MT1

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 4543
MIM: 600665
HGNC: 7463
Ensembl: ENSG00000168412

Variants:

dbSNP: 4543
ClinVar: 4543
TCGA: ENSG00000168412
COSMIC: MTNR1A

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000168412	ENST00000307161	P48039

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Neuroactive ligand-receptor interaction	KEGG	ko04080
Neuroactive ligand-receptor interaction	KEGG	hsa04080
Circadian entrainment	KEGG	hsa04713
Circadian entrainment	KEGG	ko04713
Signal Transduction	REACTOME	R-HSA-162582
Signaling by GPCR	REACTOME	R-HSA-372790
GPCR ligand binding	REACTOME	R-HSA-500792
Class A/1 (Rhodopsin-like receptors)	REACTOME	R-HSA-373076
GPCR downstream signaling	REACTOME	R-HSA-388396
G alpha (i) signalling events	REACTOME	R-HSA-418594

References

Pubmed ID	Year	Title	Citations
19913121	2009	Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.	85
11940583	2002	Monitoring of ligand-independent dimerization and ligand-induced conformational changes of melatonin receptors in living cells by bioluminescence resonance energy transfer.	64
12767050	2003	Functional activity of serotoninergic and melatoninergic systems expressed in the skin.	61
21994366	2011	The melatonin MT1 receptor axis modulates mutant Huntingtin-mediated toxicity.	41
20050373	2009	Molecular mechanisms of melatonin anticancer effects.	39
17349020	2007	Melatonin at pharmacological doses enhances human osteoblastic differentiation in vitro and promotes mouse cortical bone formation in vivo.	33
20377855	2010	Mutation screening of melatonin-related genes in patients with autism spectrum disorders.	33
18378672	2008	The PDZ protein mupp1 promotes Gi coupling and signaling of the Mt1 melatonin receptor.	29
12088876	2002	MT(1) melatonin receptor overexpression enhances the growth suppressive effect of melatonin in human breast cancer cells.	28
21818375	2011	piR_015520 belongs to Piwi-associated RNAs regulates expression of the human melatonin receptor 1A gene.	28

Citation

Dessen P

MTNR1A (melatonin receptor 1A)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45706/mtnr1a