Atlas of Genetics and Cytogenetics in Oncology and Haematology


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MTNR1B (melatonin receptor 1B)

Identity

Other aliasFGQTL2
MEL-1B-R
MT2
HGNC (Hugo) MTNR1B
LocusID (NCBI) 4544
Atlas_Id 45849
Location 11q14.3  [Link to chromosome band 11q14]
Location_base_pair Starts at 92702789 and ends at 92715948 bp from pter ( according to hg19-Feb_2009)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)MTNR1B   7464
Cards
Entrez_Gene (NCBI)MTNR1B  4544  melatonin receptor 1B
AliasesFGQTL2; MEL-1B-R; MT2
GeneCards (Weizmann)MTNR1B
Ensembl hg19 (Hinxton)ENSG00000134640 [Gene_View]  chr11:92702789-92715948 [Contig_View]  MTNR1B [Vega]
Ensembl hg38 (Hinxton)ENSG00000134640 [Gene_View]  chr11:92702789-92715948 [Contig_View]  MTNR1B [Vega]
ICGC DataPortalENSG00000134640
TCGA cBioPortalMTNR1B
AceView (NCBI)MTNR1B
Genatlas (Paris)MTNR1B
WikiGenes4544
SOURCE (Princeton)MTNR1B
Genetics Home Reference (NIH)MTNR1B
Genomic and cartography
GoldenPath hg19 (UCSC)MTNR1B  -     chr11:92702789-92715948 +  11q14.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)MTNR1B  -     11q14.3   [Description]    (hg38-Dec_2013)
EnsemblMTNR1B - 11q14.3 [CytoView hg19]  MTNR1B - 11q14.3 [CytoView hg38]
Mapping of homologs : NCBIMTNR1B [Mapview hg19]  MTNR1B [Mapview hg38]
OMIM125853   600804   
Gene and transcription
Genbank (Entrez)AF467654 AY114100 AY521019 BC069163 U25341
RefSeq transcript (Entrez)NM_005959
RefSeq genomic (Entrez)NC_000011 NC_018922 NG_028160 NT_033899 NW_004929380
Consensus coding sequences : CCDS (NCBI)MTNR1B
Cluster EST : UnigeneHs.569039 [ NCBI ]
CGAP (NCI)Hs.569039
Alternative Splicing GalleryENSG00000134640
Gene ExpressionMTNR1B [ NCBI-GEO ]   MTNR1B [ EBI - ARRAY_EXPRESS ]   MTNR1B [ SEEK ]   MTNR1B [ MEM ]
Gene Expression Viewer (FireBrowse)MTNR1B [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4544
GTEX Portal (Tissue expression)MTNR1B
Protein : pattern, domain, 3D structure
UniProt/SwissProtP49286   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP49286  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP49286
Splice isoforms : SwissVarP49286
PhosPhoSitePlusP49286
Domaine pattern : Prosite (Expaxy)G_PROTEIN_RECEP_F1_1 (PS00237)    G_PROTEIN_RECEP_F1_2 (PS50262)   
Domains : Interpro (EBI)GPCR_Rhodpsn    GPCR_Rhodpsn_7TM    Mel_1A_rcpt    Mel_rcpt_1B    Melatonin_rcpt   
Domain families : Pfam (Sanger)7tm_1 (PF00001)   
Domain families : Pfam (NCBI)pfam00001   
Conserved Domain (NCBI)MTNR1B
DMDM Disease mutations4544
Blocks (Seattle)MTNR1B
SuperfamilyP49286
Human Protein AtlasENSG00000134640
Peptide AtlasP49286
HPRD02882
IPIIPI00026564   IPI00980186   IPI00982022   
Protein Interaction databases
DIP (DOE-UCLA)P49286
IntAct (EBI)P49286
FunCoupENSG00000134640
BioGRIDMTNR1B
STRING (EMBL)MTNR1B
ZODIACMTNR1B
Ontologies - Pathways
QuickGOP49286
Ontology : AmiGOG-protein coupled receptor activity  protein binding  cytosol  plasma membrane  integral component of plasma membrane  cell surface receptor signaling pathway  G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger  synaptic transmission  circadian rhythm  melatonin receptor activity  negative regulation of cGMP metabolic process  glucose homeostasis  camera-type eye development  negative regulation of neuron apoptotic process  positive regulation of vasodilation  positive regulation of circadian sleep/wake cycle, non-REM sleep  negative regulation of insulin secretion  regulation of insulin secretion  negative regulation of cytosolic calcium ion concentration  negative regulation of transmission of nerve impulse  positive regulation of transmission of nerve impulse  regulation of neuronal action potential  negative regulation of delayed rectifier potassium channel activity  
Ontology : EGO-EBIG-protein coupled receptor activity  protein binding  cytosol  plasma membrane  integral component of plasma membrane  cell surface receptor signaling pathway  G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger  synaptic transmission  circadian rhythm  melatonin receptor activity  negative regulation of cGMP metabolic process  glucose homeostasis  camera-type eye development  negative regulation of neuron apoptotic process  positive regulation of vasodilation  positive regulation of circadian sleep/wake cycle, non-REM sleep  negative regulation of insulin secretion  regulation of insulin secretion  negative regulation of cytosolic calcium ion concentration  negative regulation of transmission of nerve impulse  positive regulation of transmission of nerve impulse  regulation of neuronal action potential  negative regulation of delayed rectifier potassium channel activity  
Pathways : KEGGNeuroactive ligand-receptor interaction    Circadian entrainment   
NDEx NetworkMTNR1B
Atlas of Cancer Signalling NetworkMTNR1B
Wikipedia pathwaysMTNR1B
Orthology - Evolution
OrthoDB4544
GeneTree (enSembl)ENSG00000134640
Phylogenetic Trees/Animal Genes : TreeFamMTNR1B
HOVERGENP49286
HOGENOMP49286
Homologs : HomoloGeneMTNR1B
Homology/Alignments : Family Browser (UCSC)MTNR1B
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMTNR1B [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MTNR1B
dbVarMTNR1B
ClinVarMTNR1B
1000_GenomesMTNR1B 
Exome Variant ServerMTNR1B
ExAC (Exome Aggregation Consortium)MTNR1B (select the gene name)
Genetic variants : HAPMAP4544
Genomic Variants (DGV)MTNR1B [DGVbeta]
DECIPHER (Syndromes)11:92702789-92715948  ENSG00000134640
CONAN: Copy Number AnalysisMTNR1B 
Mutations
ICGC Data PortalMTNR1B 
TCGA Data PortalMTNR1B 
Broad Tumor PortalMTNR1B
OASIS PortalMTNR1B [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMTNR1B  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDMTNR1B
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
BioMutasearch MTNR1B
DgiDB (Drug Gene Interaction Database)MTNR1B
DoCM (Curated mutations)MTNR1B (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MTNR1B (select a term)
intoGenMTNR1B
Cancer3DMTNR1B(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM125853    600804   
Orphanet
MedgenMTNR1B
Genetic Testing Registry MTNR1B
NextProtP49286 [Medical]
TSGene4544
GENETestsMTNR1B
Huge Navigator MTNR1B [HugePedia]
snp3D : Map Gene to Disease4544
BioCentury BCIQMTNR1B
ClinGenMTNR1B
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD4544
Chemical/Pharm GKB GenePA31268
Clinical trialMTNR1B
Miscellaneous
canSAR (ICR)MTNR1B (select the gene name)
Probes
Litterature
PubMed124 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMTNR1B
EVEXMTNR1B
GoPubMedMTNR1B
iHOPMTNR1B
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Mar 14 13:17:38 CET 2017

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