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MTO1 (mitochondrial tRNA translation optimization 1)

Identity

Alias_namesmitochondrial translation optimization 1 homolog (S. cerevisiae)
Other aliasCGI-02
COXPD10
HGNC (Hugo) MTO1
LocusID (NCBI) 25821
Atlas_Id 54043
Location 6q13  [Link to chromosome band 6q13]
Location_base_pair Starts at 73461731 and ends at 73501456 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CD109 (6q13) / MTO1 (6q13)MTO1 (6q13) / KCNQ5 (6q13)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)MTO1   19261
Cards
Entrez_Gene (NCBI)MTO1  25821  mitochondrial tRNA translation optimization 1
AliasesCGI-02; COXPD10
GeneCards (Weizmann)MTO1
Ensembl hg19 (Hinxton)ENSG00000135297 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000135297 [Gene_View]  ENSG00000135297 [Sequence]  chr6:73461731-73501456 [Contig_View]  MTO1 [Vega]
ICGC DataPortalENSG00000135297
TCGA cBioPortalMTO1
AceView (NCBI)MTO1
Genatlas (Paris)MTO1
WikiGenes25821
SOURCE (Princeton)MTO1
Genetics Home Reference (NIH)MTO1
Genomic and cartography
GoldenPath hg38 (UCSC)MTO1  -     chr6:73461731-73501456 +  6q13   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MTO1  -     6q13   [Description]    (hg19-Feb_2009)
EnsemblMTO1 - 6q13 [CytoView hg19]  MTO1 - 6q13 [CytoView hg38]
Mapping of homologs : NCBIMTO1 [Mapview hg19]  MTO1 [Mapview hg38]
OMIM614667   614702   
Gene and transcription
Genbank (Entrez)AF132937 AF319422 AF469110 AF469111 AJ420530
RefSeq transcript (Entrez)NM_001123226 NM_012123 NM_133645
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)MTO1
Cluster EST : UnigeneHs.347614 [ NCBI ]
CGAP (NCI)Hs.347614
Alternative Splicing GalleryENSG00000135297
Gene ExpressionMTO1 [ NCBI-GEO ]   MTO1 [ EBI - ARRAY_EXPRESS ]   MTO1 [ SEEK ]   MTO1 [ MEM ]
Gene Expression Viewer (FireBrowse)MTO1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)25821
GTEX Portal (Tissue expression)MTO1
Human Protein AtlasENSG00000135297-MTO1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9Y2Z2   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9Y2Z2  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9Y2Z2
Splice isoforms : SwissVarQ9Y2Z2
PhosPhoSitePlusQ9Y2Z2
Domaine pattern : Prosite (Expaxy)GIDA_1 (PS01280)    GIDA_2 (PS01281)   
Domains : Interpro (EBI)FAD/NAD-bd_sf    GidA-assoc_3    MnmG    MnmG-rel    MnmG-rel_CS   
Domain families : Pfam (Sanger)GIDA (PF01134)    GIDA_assoc (PF13932)   
Domain families : Pfam (NCBI)pfam01134    pfam13932   
Conserved Domain (NCBI)MTO1
DMDM Disease mutations25821
Blocks (Seattle)MTO1
SuperfamilyQ9Y2Z2
Human Protein Atlas [tissue]ENSG00000135297-MTO1 [tissue]
Peptide AtlasQ9Y2Z2
HPRD17611
IPIIPI00032630   IPI00180380   IPI00233661   IPI00215953   IPI00215954   IPI00890773   IPI00972946   IPI00893962   IPI00917982   IPI01013990   IPI01014419   IPI00976861   IPI00977518   
Protein Interaction databases
DIP (DOE-UCLA)Q9Y2Z2
IntAct (EBI)Q9Y2Z2
FunCoupENSG00000135297
BioGRIDMTO1
STRING (EMBL)MTO1
ZODIACMTO1
Ontologies - Pathways
QuickGOQ9Y2Z2
Ontology : AmiGOtRNA wobble uridine modification  RNA binding  mitochondrion  tRNA methylation  flavin adenine dinucleotide binding  mitochondrial tRNA wobble uridine modification  
Ontology : EGO-EBItRNA wobble uridine modification  RNA binding  mitochondrion  tRNA methylation  flavin adenine dinucleotide binding  mitochondrial tRNA wobble uridine modification  
NDEx NetworkMTO1
Atlas of Cancer Signalling NetworkMTO1
Wikipedia pathwaysMTO1
Orthology - Evolution
OrthoDB25821
GeneTree (enSembl)ENSG00000135297
Phylogenetic Trees/Animal Genes : TreeFamMTO1
HOVERGENQ9Y2Z2
HOGENOMQ9Y2Z2
Homologs : HomoloGeneMTO1
Homology/Alignments : Family Browser (UCSC)MTO1
Gene fusions - Rearrangements
Fusion : QuiverMTO1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMTO1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MTO1
dbVarMTO1
ClinVarMTO1
1000_GenomesMTO1 
Exome Variant ServerMTO1
ExAC (Exome Aggregation Consortium)ENSG00000135297
GNOMAD BrowserENSG00000135297
Varsome BrowserMTO1
Genetic variants : HAPMAP25821
Genomic Variants (DGV)MTO1 [DGVbeta]
DECIPHERMTO1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMTO1 
Mutations
ICGC Data PortalMTO1 
TCGA Data PortalMTO1 
Broad Tumor PortalMTO1
OASIS PortalMTO1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMTO1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDMTO1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch MTO1
DgiDB (Drug Gene Interaction Database)MTO1
DoCM (Curated mutations)MTO1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MTO1 (select a term)
intoGenMTO1
Cancer3DMTO1(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM614667    614702   
Orphanet21507   
DisGeNETMTO1
MedgenMTO1
Genetic Testing Registry MTO1
NextProtQ9Y2Z2 [Medical]
TSGene25821
GENETestsMTO1
Target ValidationMTO1
Huge Navigator MTO1 [HugePedia]
snp3D : Map Gene to Disease25821
BioCentury BCIQMTO1
ClinGenMTO1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD25821
Chemical/Pharm GKB GenePA134974199
Clinical trialMTO1
Miscellaneous
canSAR (ICR)MTO1 (select the gene name)
Probes
Litterature
PubMed27 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMTO1
EVEXMTO1
GoPubMedMTO1
iHOPMTO1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 6 11:24:14 CET 2018

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