Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

MTPN (myotrophin)

Identity

Alias_symbol (synonym)MYOTROPHIN
GCDP
V-1
Other alias
HGNC (Hugo) MTPN
LocusID (NCBI) 136319
Atlas_Id 70564
Location 7q33  [Link to chromosome band 7q33]
Location_base_pair Starts at 135926755 and ends at 135977456 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CFL1 (11q13.1) / MTPN (7q33)CLTA (9p13.3) / MTPN (7q33)MTPN (7q33) / CA12 (15q22.2)
MTPN (7q33) / MTPN (7q33)MTPN (7q33) / RBPMS (8p12)MVP (16p11.2) / MTPN (7q33)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)MTPN   15667
Cards
Entrez_Gene (NCBI)MTPN  136319  myotrophin
AliasesGCDP; V-1
GeneCards (Weizmann)MTPN
Ensembl hg19 (Hinxton)ENSG00000105887 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000105887 [Gene_View]  chr7:135926755-135977456 [Contig_View]  MTPN [Vega]
ICGC DataPortalENSG00000105887
TCGA cBioPortalMTPN
AceView (NCBI)MTPN
Genatlas (Paris)MTPN
WikiGenes136319
SOURCE (Princeton)MTPN
Genetics Home Reference (NIH)MTPN
Genomic and cartography
GoldenPath hg38 (UCSC)MTPN  -     chr7:135926755-135977456 -  7q33   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MTPN  -     7q33   [Description]    (hg19-Feb_2009)
EnsemblMTPN - 7q33 [CytoView hg19]  MTPN - 7q33 [CytoView hg38]
Mapping of homologs : NCBIMTPN [Mapview hg19]  MTPN [Mapview hg38]
OMIM606484   
Gene and transcription
Genbank (Entrez)AF106075 AK055660 AK056225 AK309816 AL110137
RefSeq transcript (Entrez)NM_145808
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)MTPN
Cluster EST : UnigeneHs.602015 [ NCBI ]
CGAP (NCI)Hs.602015
Alternative Splicing GalleryENSG00000105887
Gene ExpressionMTPN [ NCBI-GEO ]   MTPN [ EBI - ARRAY_EXPRESS ]   MTPN [ SEEK ]   MTPN [ MEM ]
Gene Expression Viewer (FireBrowse)MTPN [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)136319
GTEX Portal (Tissue expression)MTPN
Human Protein AtlasENSG00000105887-MTPN [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP58546   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP58546  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP58546
Splice isoforms : SwissVarP58546
PhosPhoSitePlusP58546
Domaine pattern : Prosite (Expaxy)ANK_REP_REGION (PS50297)    ANK_REPEAT (PS50088)   
Domains : Interpro (EBI)Ankyrin_rpt    Ankyrin_rpt-contain_dom   
Domain families : Pfam (Sanger)Ank_2 (PF12796)   
Domain families : Pfam (NCBI)pfam12796   
Domain families : Smart (EMBL)ANK (SM00248)  
Conserved Domain (NCBI)MTPN
DMDM Disease mutations136319
Blocks (Seattle)MTPN
PDB (SRS)3AAA   
PDB (PDBSum)3AAA   
PDB (IMB)3AAA   
PDB (RSDB)3AAA   
Structural Biology KnowledgeBase3AAA   
SCOP (Structural Classification of Proteins)3AAA   
CATH (Classification of proteins structures)3AAA   
SuperfamilyP58546
Human Protein Atlas [tissue]ENSG00000105887-MTPN [tissue]
Peptide AtlasP58546
HPRD07574
IPIIPI00924816   IPI00010559   IPI00926178   
Protein Interaction databases
DIP (DOE-UCLA)P58546
IntAct (EBI)P58546
FunCoupENSG00000105887
BioGRIDMTPN
STRING (EMBL)MTPN
ZODIACMTPN
Ontologies - Pathways
QuickGOP58546
Ontology : AmiGOnucleus  cytosol  regulation of translation  catecholamine metabolic process  F-actin capping protein complex  positive regulation of macromolecule biosynthetic process  positive regulation of cardiac muscle hypertrophy  cell growth  regulation of striated muscle tissue development  cerebellar granule cell differentiation  neuron differentiation  positive regulation of cell growth  axon  skeletal muscle tissue regeneration  sequence-specific DNA binding  perinuclear region of cytoplasm  positive regulation of NF-kappaB transcription factor activity  striated muscle cell differentiation  positive regulation of protein metabolic process  extracellular exosome  cellular response to mechanical stimulus  regulation of barbed-end actin filament capping  
Ontology : EGO-EBInucleus  cytosol  regulation of translation  catecholamine metabolic process  F-actin capping protein complex  positive regulation of macromolecule biosynthetic process  positive regulation of cardiac muscle hypertrophy  cell growth  regulation of striated muscle tissue development  cerebellar granule cell differentiation  neuron differentiation  positive regulation of cell growth  axon  skeletal muscle tissue regeneration  sequence-specific DNA binding  perinuclear region of cytoplasm  positive regulation of NF-kappaB transcription factor activity  striated muscle cell differentiation  positive regulation of protein metabolic process  extracellular exosome  cellular response to mechanical stimulus  regulation of barbed-end actin filament capping  
NDEx NetworkMTPN
Atlas of Cancer Signalling NetworkMTPN
Wikipedia pathwaysMTPN
Orthology - Evolution
OrthoDB136319
GeneTree (enSembl)ENSG00000105887
Phylogenetic Trees/Animal Genes : TreeFamMTPN
HOVERGENP58546
HOGENOMP58546
Homologs : HomoloGeneMTPN
Homology/Alignments : Family Browser (UCSC)MTPN
Gene fusions - Rearrangements
Fusion: Tumor Portal MTPN
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMTPN [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MTPN
dbVarMTPN
ClinVarMTPN
1000_GenomesMTPN 
Exome Variant ServerMTPN
ExAC (Exome Aggregation Consortium)ENSG00000105887
GNOMAD BrowserENSG00000105887
Genetic variants : HAPMAP136319
Genomic Variants (DGV)MTPN [DGVbeta]
DECIPHERMTPN [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMTPN 
Mutations
ICGC Data PortalMTPN 
TCGA Data PortalMTPN 
Broad Tumor PortalMTPN
OASIS PortalMTPN [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMTPN  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDMTPN
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch MTPN
DgiDB (Drug Gene Interaction Database)MTPN
DoCM (Curated mutations)MTPN (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MTPN (select a term)
intoGenMTPN
Cancer3DMTPN(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606484   
Orphanet
MedgenMTPN
Genetic Testing Registry MTPN
NextProtP58546 [Medical]
TSGene136319
GENETestsMTPN
Target ValidationMTPN
Huge Navigator MTPN [HugePedia]
snp3D : Map Gene to Disease136319
BioCentury BCIQMTPN
ClinGenMTPN
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD136319
Chemical/Pharm GKB GenePA31271
Clinical trialMTPN
Miscellaneous
canSAR (ICR)MTPN (select the gene name)
Probes
Litterature
PubMed34 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMTPN
EVEXMTPN
GoPubMedMTPN
iHOPMTPN
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Nov 9 12:18:12 CET 2017

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.