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MTRF1 (mitochondrial translation release factor 1)

Identity

Alias (NCBI)MRF1
MTTRF1
RF1
HGNC (Hugo) MTRF1
HGNC Alias symbRF1
MTTRF1
MGC47721
HGNC Alias namemitochontrial peptide chain release factor 1
HGNC Previous namemitochondrial translational release factor 1
LocusID (NCBI) 9617
Atlas_Id 54479
Location 13q14.11  [Link to chromosome band 13q14]
Location_base_pair Starts at 41216369 and ends at 41263576 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
FREM2 (13q13.3) / MTRF1 (13q14.11)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(13;13)(q13;q14) FREM2/MTRF1


External links

Nomenclature
HGNC (Hugo)MTRF1   7469
Cards
Entrez_Gene (NCBI)MTRF1    mitochondrial translation release factor 1
AliasesMRF1; MTTRF1; RF1
GeneCards (Weizmann)MTRF1
Ensembl hg19 (Hinxton)ENSG00000120662 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000120662 [Gene_View]  ENSG00000120662 [Sequence]  chr13:41216369-41263576 [Contig_View]  MTRF1 [Vega]
ICGC DataPortalENSG00000120662
TCGA cBioPortalMTRF1
AceView (NCBI)MTRF1
Genatlas (Paris)MTRF1
SOURCE (Princeton)MTRF1
Genetics Home Reference (NIH)MTRF1
Genomic and cartography
GoldenPath hg38 (UCSC)MTRF1  -     chr13:41216369-41263576 -  13q14.11   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MTRF1  -     13q14.11   [Description]    (hg19-Feb_2009)
GoldenPathMTRF1 - 13q14.11 [CytoView hg19]  MTRF1 - 13q14.11 [CytoView hg38]
ImmunoBaseENSG00000120662
genome Data Viewer NCBIMTRF1 [Mapview hg19]  
OMIM604601   
Gene and transcription
Genbank (Entrez)AA573449 AF072934 AK055086 AK294343 BC027731
RefSeq transcript (Entrez)NM_001354073 NM_001354074 NM_001354076 NM_004294
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)MTRF1
Alternative Splicing GalleryENSG00000120662
Gene ExpressionMTRF1 [ NCBI-GEO ]   MTRF1 [ EBI - ARRAY_EXPRESS ]   MTRF1 [ SEEK ]   MTRF1 [ MEM ]
Gene Expression Viewer (FireBrowse)MTRF1 [ Firebrowse - Broad ]
GenevisibleExpression of MTRF1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9617
GTEX Portal (Tissue expression)MTRF1
Human Protein AtlasENSG00000120662-MTRF1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO75570   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO75570  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO75570
Splice isoforms : SwissVarO75570
PhosPhoSitePlusO75570
Domaine pattern : Prosite (Expaxy)RF_PROK_I (PS00745)   
Domains : Interpro (EBI)PCRF    Pep_chain_release_fac_I   
Domain families : Pfam (Sanger)PCRF (PF03462)    RF-1 (PF00472)   
Domain families : Pfam (NCBI)pfam03462    pfam00472   
Domain families : Smart (EMBL)PCRF (SM00937)  
Conserved Domain (NCBI)MTRF1
Blocks (Seattle)MTRF1
SuperfamilyO75570
Human Protein Atlas [tissue]ENSG00000120662-MTRF1 [tissue]
Peptide AtlasO75570
HPRD06855
IPIIPI00026157   IPI00909024   IPI00167143   IPI00642465   
Protein Interaction databases
DIP (DOE-UCLA)O75570
IntAct (EBI)O75570
BioGRIDMTRF1
STRING (EMBL)MTRF1
ZODIACMTRF1
Ontologies - Pathways
QuickGOO75570
Ontology : AmiGOtranslation release factor activity  mitochondrion  regulation of translational termination  mitochondrial translational termination  
Ontology : EGO-EBItranslation release factor activity  mitochondrion  regulation of translational termination  mitochondrial translational termination  
NDEx NetworkMTRF1
Atlas of Cancer Signalling NetworkMTRF1
Wikipedia pathwaysMTRF1
Orthology - Evolution
OrthoDB9617
GeneTree (enSembl)ENSG00000120662
Phylogenetic Trees/Animal Genes : TreeFamMTRF1
HOGENOMO75570
Homologs : HomoloGeneMTRF1
Homology/Alignments : Family Browser (UCSC)MTRF1
Gene fusions - Rearrangements
Fusion : MitelmanFREM2/MTRF1 [13q13.3/13q14.11]  
Fusion : QuiverMTRF1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMTRF1 [hg38]
dbVarMTRF1
ClinVarMTRF1
MonarchMTRF1
1000_GenomesMTRF1 
Exome Variant ServerMTRF1
GNOMAD BrowserENSG00000120662
Varsome BrowserMTRF1
Genomic Variants (DGV)MTRF1 [DGVbeta]
DECIPHERMTRF1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMTRF1 
Mutations
ICGC Data PortalMTRF1 
TCGA Data PortalMTRF1 
Broad Tumor PortalMTRF1
OASIS PortalMTRF1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMTRF1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DMTRF1
Mutations and Diseases : HGMDMTRF1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch MTRF1
DgiDB (Drug Gene Interaction Database)MTRF1
DoCM (Curated mutations)MTRF1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MTRF1 (select a term)
intoGenMTRF1
Cancer3DMTRF1(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604601   
Orphanet
DisGeNETMTRF1
MedgenMTRF1
Genetic Testing Registry MTRF1
NextProtO75570 [Medical]
GENETestsMTRF1
Target ValidationMTRF1
Huge Navigator MTRF1 [HugePedia]
ClinGenMTRF1
Clinical trials, drugs, therapy
MyCancerGenomeMTRF1
Protein Interactions : CTD
Pharm GKB GenePA31273
PharosO75570
Clinical trialMTRF1
Miscellaneous
canSAR (ICR)MTRF1 (select the gene name)
HarmonizomeMTRF1
DataMed IndexMTRF1
Probes
Litterature
PubMed14 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXMTRF1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Fri Jan 1 18:27:43 CET 2021

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