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MTRF1 (mitochondrial translation release factor 1)

Identity

Alias_namesmitochondrial translational release factor 1
Alias_symbol (synonym)RF1
MTTRF1
MGC47721
Other aliasMRF1
HGNC (Hugo) MTRF1
LocusID (NCBI) 9617
Atlas_Id 54479
Location 13q14.11  [Link to chromosome band 13q14]
Location_base_pair Starts at 41216380 and ends at 41263577 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
FREM2 (13q13.3) / MTRF1 (13q14.11)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)MTRF1   7469
Cards
Entrez_Gene (NCBI)MTRF1  9617  mitochondrial translation release factor 1
AliasesMRF1; MTTRF1; RF1
GeneCards (Weizmann)MTRF1
Ensembl hg19 (Hinxton)ENSG00000120662 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000120662 [Gene_View]  chr13:41216380-41263577 [Contig_View]  MTRF1 [Vega]
ICGC DataPortalENSG00000120662
TCGA cBioPortalMTRF1
AceView (NCBI)MTRF1
Genatlas (Paris)MTRF1
WikiGenes9617
SOURCE (Princeton)MTRF1
Genetics Home Reference (NIH)MTRF1
Genomic and cartography
GoldenPath hg38 (UCSC)MTRF1  -     chr13:41216380-41263577 -  13q14.11   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MTRF1  -     13q14.11   [Description]    (hg19-Feb_2009)
EnsemblMTRF1 - 13q14.11 [CytoView hg19]  MTRF1 - 13q14.11 [CytoView hg38]
Mapping of homologs : NCBIMTRF1 [Mapview hg19]  MTRF1 [Mapview hg38]
OMIM604601   
Gene and transcription
Genbank (Entrez)AA573449 AF072934 AK055086 AK294343 BC027731
RefSeq transcript (Entrez)NM_004294
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)MTRF1
Cluster EST : UnigeneHs.382176 [ NCBI ]
CGAP (NCI)Hs.382176
Alternative Splicing GalleryENSG00000120662
Gene ExpressionMTRF1 [ NCBI-GEO ]   MTRF1 [ EBI - ARRAY_EXPRESS ]   MTRF1 [ SEEK ]   MTRF1 [ MEM ]
Gene Expression Viewer (FireBrowse)MTRF1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9617
GTEX Portal (Tissue expression)MTRF1
Human Protein AtlasENSG00000120662-MTRF1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO75570   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO75570  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO75570
Splice isoforms : SwissVarO75570
PhosPhoSitePlusO75570
Domaine pattern : Prosite (Expaxy)RF_PROK_I (PS00745)   
Domains : Interpro (EBI)dsRBD_dom    PCRF    Pep_chain_release_fac_I_II   
Domain families : Pfam (Sanger)PCRF (PF03462)    RF-1 (PF00472)   
Domain families : Pfam (NCBI)pfam03462    pfam00472   
Domain families : Smart (EMBL)PCRF (SM00937)  
Conserved Domain (NCBI)MTRF1
DMDM Disease mutations9617
Blocks (Seattle)MTRF1
SuperfamilyO75570
Human Protein Atlas [tissue]ENSG00000120662-MTRF1 [tissue]
Peptide AtlasO75570
HPRD06855
IPIIPI00026157   IPI00909024   IPI00167143   IPI00642465   
Protein Interaction databases
DIP (DOE-UCLA)O75570
IntAct (EBI)O75570
FunCoupENSG00000120662
BioGRIDMTRF1
STRING (EMBL)MTRF1
ZODIACMTRF1
Ontologies - Pathways
QuickGOO75570
Ontology : AmiGOtranslation release factor activity  mitochondrion  translational termination  regulation of translational termination  translation release factor activity, codon specific  
Ontology : EGO-EBItranslation release factor activity  mitochondrion  translational termination  regulation of translational termination  translation release factor activity, codon specific  
NDEx NetworkMTRF1
Atlas of Cancer Signalling NetworkMTRF1
Wikipedia pathwaysMTRF1
Orthology - Evolution
OrthoDB9617
GeneTree (enSembl)ENSG00000120662
Phylogenetic Trees/Animal Genes : TreeFamMTRF1
HOVERGENO75570
HOGENOMO75570
Homologs : HomoloGeneMTRF1
Homology/Alignments : Family Browser (UCSC)MTRF1
Gene fusions - Rearrangements
Fusion : MitelmanFREM2/MTRF1 [13q13.3/13q14.11]  [t(13;13)(q13;q14)]  
Tumor Fusion PortalMTRF1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMTRF1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MTRF1
dbVarMTRF1
ClinVarMTRF1
1000_GenomesMTRF1 
Exome Variant ServerMTRF1
ExAC (Exome Aggregation Consortium)ENSG00000120662
GNOMAD BrowserENSG00000120662
Genetic variants : HAPMAP9617
Genomic Variants (DGV)MTRF1 [DGVbeta]
DECIPHERMTRF1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMTRF1 
Mutations
ICGC Data PortalMTRF1 
TCGA Data PortalMTRF1 
Broad Tumor PortalMTRF1
OASIS PortalMTRF1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMTRF1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDMTRF1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch MTRF1
DgiDB (Drug Gene Interaction Database)MTRF1
DoCM (Curated mutations)MTRF1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MTRF1 (select a term)
intoGenMTRF1
Cancer3DMTRF1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604601   
Orphanet
DisGeNETMTRF1
MedgenMTRF1
Genetic Testing Registry MTRF1
NextProtO75570 [Medical]
TSGene9617
GENETestsMTRF1
Target ValidationMTRF1
Huge Navigator MTRF1 [HugePedia]
snp3D : Map Gene to Disease9617
BioCentury BCIQMTRF1
ClinGenMTRF1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD9617
Chemical/Pharm GKB GenePA31273
Clinical trialMTRF1
Miscellaneous
canSAR (ICR)MTRF1 (select the gene name)
Probes
Litterature
PubMed12 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMTRF1
EVEXMTRF1
GoPubMedMTRF1
iHOPMTRF1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Nov 21 14:25:02 CET 2017

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