| Nomenclature |
|---|
| HGNC (Hugo) | MTRR 7473 |
| Cards |
|---|
| Entrez_Gene (NCBI) | MTRR 5-methyltetrahydrofolate-homocysteine methyltransferase reductase |
| Aliases | MSR; cblE |
| GeneCards (Weizmann) | MTRR |
| Ensembl hg19 (Hinxton) | ENSG00000124275 [Gene_View] |
| Ensembl hg38 (Hinxton) | ENSG00000124275 [Gene_View] ENSG00000124275 [Sequence] chr5:7869148-7901113 [Contig_View] MTRR [Vega] |
| ICGC DataPortal | ENSG00000124275 |
| TCGA cBioPortal | MTRR |
| AceView (NCBI) | MTRR |
| Genatlas (Paris) | MTRR |
| SOURCE (Princeton) | MTRR |
| Genetics Home Reference (NIH) | MTRR |
| Genomic and cartography |
|---|
| GoldenPath hg38 (UCSC) | MTRR - chr5:7869148-7901113 + 5p15.31 [Description] (hg38-Dec_2013) |
| GoldenPath hg19 (UCSC) | MTRR - 5p15.31 [Description] (hg19-Feb_2009) |
| GoldenPath | MTRR - 5p15.31 [CytoView hg19] MTRR - 5p15.31 [CytoView hg38] |
| ImmunoBase | ENSG00000124275 |
| Genome Data Viewer NCBI | MTRR [Mapview hg19] |
| OMIM | 236270 601634 602568 |
| Gene and transcription |
|---|
| Genbank (Entrez) | AF025794 AF121214 AK308442 AK311663 BC035977 |
| RefSeq transcript (Entrez) | NM_001364440 NM_001364441 NM_001364442 NM_002454 NM_024010 |
| Consensus coding sequences : CCDS (NCBI) | MTRR |
| Gene Expression | MTRR [ NCBI-GEO ] MTRR [ EBI - ARRAY_EXPRESS ]
MTRR [ SEEK ] MTRR [ MEM ] |
| Gene Expression Viewer (FireBrowse) | MTRR [ Firebrowse - Broad ] |
| Genevisible | Expression of MTRR in : [tissues] [cell-lines] [cancer] [perturbations] |
| BioGPS (Tissue expression) | 4552 |
| GTEX Portal (Tissue expression) | MTRR |
| Human Protein Atlas | ENSG00000124275-MTRR [pathology] [cell] [tissue] |
| Protein : pattern, domain, 3D structure |
|---|
| UniProt/SwissProt | Q9UBK8 [function] [subcellular_location] [family_and_domains] [pathology_and_biotech] [ptm_processing] [expression] [interaction] |
| NextProt | Q9UBK8 [Sequence] [Exons] [Medical] [Publications] |
| With graphics : InterPro | Q9UBK8 |
| PhosPhoSitePlus | Q9UBK8 |
| Domaine pattern : Prosite (Expaxy) | FAD_FR (PS51384) FLAVODOXIN_LIKE (PS50902) |
| Domains : Interpro (EBI) | CysJ-like_FAD-binding FAD-bd_FR_type Flavdoxin-like Flavodoxin/NO_synth Flavoprot_Pyr_Nucl_cyt_Rdtase Flavoprotein-like_sf FNR_nucleotide-bd NADPH_Cyt_P450_Rdtase_alpha OxRdtase_FAD/NAD-bd Riboflavin_synthase-like_b-brl |
| Domain families : Pfam (Sanger) | FAD_binding_1 (PF00667) Flavodoxin_1 (PF00258) NAD_binding_1 (PF00175) |
| Domain families : Pfam (NCBI) | pfam00667 pfam00258 pfam00175 |
| Conserved Domain (NCBI) | MTRR |
| PDB (RSDB) | 2QTL 2QTZ |
| PDB Europe | 2QTL 2QTZ |
| PDB (PDBSum) | 2QTL 2QTZ |
| PDB (IMB) | 2QTL 2QTZ |
| Structural Biology KnowledgeBase | 2QTL 2QTZ |
| SCOP (Structural Classification of Proteins) | 2QTL 2QTZ |
| CATH (Classification of proteins structures) | 2QTL 2QTZ |
| Superfamily | Q9UBK8 |
| AlphaFold pdb e-kb | Q9UBK8 |
| Human Protein Atlas [tissue] | ENSG00000124275-MTRR [tissue] |
| HPRD | 03979 |
| Protein Interaction databases |
|---|
| DIP (DOE-UCLA) | Q9UBK8 |
| IntAct (EBI) | Q9UBK8 |
| BioGRID | MTRR |
| STRING (EMBL) | MTRR |
| ZODIAC | MTRR |
| Ontologies - Pathways |
|---|
| QuickGO | Q9UBK8 |
| Ontology : AmiGO | sulfur amino acid metabolic process NADPH-hemoprotein reductase activity protein binding nucleoplasm cytosol cytosol cytosol DNA methylation methionine biosynthetic process methionine biosynthetic process cobalamin metabolic process FMN binding FMN binding oxidoreductase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen oxidoreductase activity, acting on metal ions, NAD or NADP as acceptor [methionine synthase] reductase activity [methionine synthase] reductase activity [methionine synthase] reductase activity methylation S-adenosylmethionine cycle homocysteine catabolic process intermediate filament cytoskeleton folic acid metabolic process folic acid metabolic process flavin adenine dinucleotide binding flavin adenine dinucleotide binding homocysteine metabolic process NADPH binding FAD binding negative regulation of cystathionine beta-synthase activity |
| Ontology : EGO-EBI | sulfur amino acid metabolic process NADPH-hemoprotein reductase activity protein binding nucleoplasm cytosol cytosol cytosol DNA methylation methionine biosynthetic process methionine biosynthetic process cobalamin metabolic process FMN binding FMN binding oxidoreductase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen oxidoreductase activity, acting on metal ions, NAD or NADP as acceptor [methionine synthase] reductase activity [methionine synthase] reductase activity [methionine synthase] reductase activity methylation S-adenosylmethionine cycle homocysteine catabolic process intermediate filament cytoskeleton folic acid metabolic process folic acid metabolic process flavin adenine dinucleotide binding flavin adenine dinucleotide binding homocysteine metabolic process NADPH binding FAD binding negative regulation of cystathionine beta-synthase activity |
| NDEx Network | MTRR |
| Atlas of Cancer Signalling Network | MTRR |
| Wikipedia pathways | MTRR |
| Orthology - Evolution |
|---|
| OrthoDB | 4552 |
| GeneTree (enSembl) | ENSG00000124275 |
| Phylogenetic Trees/Animal Genes : TreeFam | MTRR |
| Homologs : HomoloGene | MTRR |
| Homology/Alignments : Family Browser (UCSC) | MTRR |
| Gene fusions - Rearrangements |
|---|
| Fusion : Mitelman | GPBP1::MTRR [5q11.2/5p15.31] |
| Fusion : Mitelman | MTRR::NMD3 [5p15.31/3q26.1] |
| Fusion : Quiver | MTRR |
| Polymorphisms : SNP and Copy number variants |
|---|
| NCBI Variation Viewer | MTRR [hg38] |
| dbSNP Single Nucleotide Polymorphism (NCBI) | MTRR |
| dbVar | MTRR |
| ClinVar | MTRR |
| Monarch | MTRR |
| 1000_Genomes | MTRR |
| Exome Variant Server | MTRR |
| GNOMAD Browser | ENSG00000124275 |
| Varsome Browser | MTRR |
| ACMG | MTRR variants |
| Varity | Q9UBK8 |
| Genomic Variants (DGV) | MTRR [DGVbeta] |
| DECIPHER | MTRR [patients] [syndromes] [variants] [genes] |
| CONAN: Copy Number Analysis | MTRR |
| Mutations |
|---|
| ICGC Data Portal | MTRR |
| TCGA Data Portal | MTRR |
| Broad Tumor Portal | MTRR |
| OASIS Portal | MTRR [ Somatic mutations - Copy number] |
| Somatic Mutations in Cancer : COSMIC | MTRR [overview] [genome browser] [tissue] [distribution] |
| Somatic Mutations in Cancer : COSMIC3D | MTRR |
| Mutations and Diseases : HGMD | MTRR |
| LOVD (Leiden Open Variation Database) | [gene] [transcripts] [variants] |
| BioMuta | MTRR |
| DgiDB (Drug Gene Interaction Database) | MTRR |
| DoCM (Curated mutations) | MTRR |
| CIViC (Clinical Interpretations of Variants in Cancer) | MTRR |
| Cancer3D | MTRR |
| Impact of mutations | [PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser] |
| Diseases |
|---|
| OMIM | 236270 601634 602568 |
| Orphanet | 2063 |
| DisGeNET | MTRR |
| Medgen | MTRR |
| Genetic Testing Registry | MTRR
|
| NextProt | Q9UBK8 [Medical] |
| GENETests | MTRR |
| Target Validation | MTRR |
| Huge Navigator |
MTRR [HugePedia] |
| ClinGen | MTRR |
| Clinical trials, drugs, therapy |
|---|
| MyCancerGenome | MTRR |
| Protein Interactions : CTD | MTRR |
| Pharm GKB Gene | PA31277 |
| Pharm GKB Pathways | PA165291575 PA2039 |
| Pharos | Q9UBK8 |
| Clinical trial | MTRR |
| Miscellaneous |
|---|
| canSAR (ICR) | MTRR |
| Harmonizome | MTRR |
| ARCHS4 | MTRR |
| DataMed Index | MTRR |
| Probes |
|---|
| Litterature |
|---|
| PubMed | 360 Pubmed reference(s) in Entrez |
| GeneRIFs | Gene References Into Functions (Entrez) |
| EVEX | MTRR |
