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MTSS1 (metastasis suppressor 1)

Identity

Alias_namesmetastasis suppressor 1
Alias_symbol (synonym)KIAA0429
MIMA
MIMB
MIM
HGNC (Hugo) MTSS1
LocusID (NCBI) 9788
Atlas_Id 41450
Location 8q24.13  [Link to chromosome band 8q24]
Location_base_pair Starts at 125563011 and ends at 125740748 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
MTSS1 (8q24.13) / ATE1 (10q26.13)MTSS1 (8q24.13) / DDX27 (20q13.13)MTSS1 (8q24.13) / ERBB2 (17q12)
MTSS1 (8q24.13) / FGFR2 (10q26.13)MTSS1 (8q24.13) / KIAA0196 (8q24.13)MTSS1 (8q24.13) / ST3GAL1 (8q24.22)
MTSS1 (8q24.13) / WHSC1L1 (8p11.23)MTSS1 (8q24.13) / ZC2HC1A (8q21.12)TATDN1 (8q24.13) / MTSS1 (8q24.13)
THOC2 (Xq25) / MTSS1 (8q24.13)MTSS1 8q24.13 / DDX27 20q13.13MTSS1 8q24.13 FAM164A
MTSS1 8q24.13 / ST3GAL1 8q24.22MTSS1 8q24.13 / WHSC1L1 8p11.23

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)MTSS1   20443
Cards
Entrez_Gene (NCBI)MTSS1  9788  metastasis suppressor 1
AliasesMIM; MIMA; MIMB
GeneCards (Weizmann)MTSS1
Ensembl hg19 (Hinxton)ENSG00000170873 [Gene_View]  chr8:125563011-125740748 [Contig_View]  MTSS1 [Vega]
Ensembl hg38 (Hinxton)ENSG00000170873 [Gene_View]  chr8:125563011-125740748 [Contig_View]  MTSS1 [Vega]
ICGC DataPortalENSG00000170873
TCGA cBioPortalMTSS1
AceView (NCBI)MTSS1
Genatlas (Paris)MTSS1
WikiGenes9788
SOURCE (Princeton)MTSS1
Genetics Home Reference (NIH)MTSS1
Genomic and cartography
GoldenPath hg19 (UCSC)MTSS1  -     chr8:125563011-125740748 -  8q24.13   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)MTSS1  -     8q24.13   [Description]    (hg38-Dec_2013)
EnsemblMTSS1 - 8q24.13 [CytoView hg19]  MTSS1 - 8q24.13 [CytoView hg38]
Mapping of homologs : NCBIMTSS1 [Mapview hg19]  MTSS1 [Mapview hg38]
OMIM608486   
Gene and transcription
Genbank (Entrez)AB007889 AF086645 AF116674 AI041104 AJ710067
RefSeq transcript (Entrez)NM_001282971 NM_001282974 NM_014751
RefSeq genomic (Entrez)NC_000008 NC_018919 NT_008046 NW_004929340
Consensus coding sequences : CCDS (NCBI)MTSS1
Cluster EST : UnigeneHs.700429 [ NCBI ]
CGAP (NCI)Hs.700429
Alternative Splicing GalleryENSG00000170873
Gene ExpressionMTSS1 [ NCBI-GEO ]   MTSS1 [ EBI - ARRAY_EXPRESS ]   MTSS1 [ SEEK ]   MTSS1 [ MEM ]
Gene Expression Viewer (FireBrowse)MTSS1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9788
GTEX Portal (Tissue expression)MTSS1
Protein : pattern, domain, 3D structure
UniProt/SwissProtO43312   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO43312  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO43312
Splice isoforms : SwissVarO43312
PhosPhoSitePlusO43312
Domaine pattern : Prosite (Expaxy)IMD (PS51338)    WH2 (PS51082)   
Domains : Interpro (EBI)I-BAR_dom    MIM    MIM/ABBA    WH2_dom   
Domain families : Pfam (Sanger)IMD (PF08397)    WH2 (PF02205)   
Domain families : Pfam (NCBI)pfam08397    pfam02205   
Domain families : Smart (EMBL)WH2 (SM00246)  
Conserved Domain (NCBI)MTSS1
DMDM Disease mutations9788
Blocks (Seattle)MTSS1
PDB (SRS)2D1K   
PDB (PDBSum)2D1K   
PDB (IMB)2D1K   
PDB (RSDB)2D1K   
Structural Biology KnowledgeBase2D1K   
SCOP (Structural Classification of Proteins)2D1K   
CATH (Classification of proteins structures)2D1K   
SuperfamilyO43312
Human Protein AtlasENSG00000170873
Peptide AtlasO43312
HPRD12243
IPIIPI00983960   IPI00647454   IPI00444645   IPI00922364   IPI00445073   IPI00383355   IPI00152331   IPI00982324   IPI00975593   IPI00976780   IPI00980503   
Protein Interaction databases
DIP (DOE-UCLA)O43312
IntAct (EBI)O43312
FunCoupENSG00000170873
BioGRIDMTSS1
STRING (EMBL)MTSS1
ZODIACMTSS1
Ontologies - Pathways
QuickGOO43312
Ontology : AmiGOruffle  positive regulation of defense response to virus by host  actin monomer binding  receptor binding  protein binding  cytoplasm  movement of cell or subcellular component  plasma membrane organization  cell adhesion  transmembrane receptor protein tyrosine kinase signaling pathway  actin cytoskeleton  microspike assembly  actin cytoskeleton organization  endocytic vesicle  identical protein binding  negative regulation of epithelial cell proliferation  renal tubule morphogenesis  cellular response to fluid shear stress  glomerulus morphogenesis  nephron tubule epithelial cell differentiation  xenophagy  epithelial cell proliferation involved in renal tubule morphogenesis  
Ontology : EGO-EBIruffle  positive regulation of defense response to virus by host  actin monomer binding  receptor binding  protein binding  cytoplasm  movement of cell or subcellular component  plasma membrane organization  cell adhesion  transmembrane receptor protein tyrosine kinase signaling pathway  actin cytoskeleton  microspike assembly  actin cytoskeleton organization  endocytic vesicle  identical protein binding  negative regulation of epithelial cell proliferation  renal tubule morphogenesis  cellular response to fluid shear stress  glomerulus morphogenesis  nephron tubule epithelial cell differentiation  xenophagy  epithelial cell proliferation involved in renal tubule morphogenesis  
NDEx NetworkMTSS1
Atlas of Cancer Signalling NetworkMTSS1
Wikipedia pathwaysMTSS1
Orthology - Evolution
OrthoDB9788
GeneTree (enSembl)ENSG00000170873
Phylogenetic Trees/Animal Genes : TreeFamMTSS1
HOVERGENO43312
HOGENOMO43312
Homologs : HomoloGeneMTSS1
Homology/Alignments : Family Browser (UCSC)MTSS1
Gene fusions - Rearrangements
Fusion : MitelmanMTSS1/DDX27 [8q24.13/20q13.13]  
Fusion : MitelmanMTSS1/ST3GAL1 [8q24.13/8q24.22]  [t(8;8)(q24;q24)]  
Fusion : MitelmanMTSS1/WHSC1L1 [8q24.13/8p11.23]  [t(8;8)(p12;q24)]  
Fusion : MitelmanMTSS1/ZC2HC1A [8q24.13/8q21.12]  [t(8;8)(q21;q24)]  
Fusion: TCGAMTSS1 8q24.13 DDX27 20q13.13 KIRC
Fusion: TCGAMTSS1 8q24.13 FAM164A BRCA
Fusion: TCGAMTSS1 8q24.13 ST3GAL1 8q24.22 BRCA
Fusion: TCGAMTSS1 8q24.13 WHSC1L1 8p11.23 SKCM
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMTSS1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MTSS1
dbVarMTSS1
ClinVarMTSS1
1000_GenomesMTSS1 
Exome Variant ServerMTSS1
ExAC (Exome Aggregation Consortium)MTSS1 (select the gene name)
Genetic variants : HAPMAP9788
Genomic Variants (DGV)MTSS1 [DGVbeta]
DECIPHER (Syndromes)8:125563011-125740748  ENSG00000170873
CONAN: Copy Number AnalysisMTSS1 
Mutations
ICGC Data PortalMTSS1 
TCGA Data PortalMTSS1 
Broad Tumor PortalMTSS1
OASIS PortalMTSS1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMTSS1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDMTSS1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch MTSS1
DgiDB (Drug Gene Interaction Database)MTSS1
DoCM (Curated mutations)MTSS1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MTSS1 (select a term)
intoGenMTSS1
Cancer3DMTSS1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM608486   
Orphanet
MedgenMTSS1
Genetic Testing Registry MTSS1
NextProtO43312 [Medical]
TSGene9788
GENETestsMTSS1
Huge Navigator MTSS1 [HugePedia]
snp3D : Map Gene to Disease9788
BioCentury BCIQMTSS1
ClinGenMTSS1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD9788
Chemical/Pharm GKB GenePA134892011
Clinical trialMTSS1
Miscellaneous
canSAR (ICR)MTSS1 (select the gene name)
Probes
Litterature
PubMed50 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMTSS1
EVEXMTSS1
GoPubMedMTSS1
iHOPMTSS1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Nov 18 19:45:04 CET 2016

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