Atlas of Genetics and Cytogenetics in Oncology and Haematology


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MTX2 (metaxin 2)

Identity

Other alias-
HGNC (Hugo) MTX2
LocusID (NCBI) 10651
Atlas_Id 70579
Location 2q31.1  [Link to chromosome band 2q31]
Location_base_pair Starts at 176269395 and ends at 176338025 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
MTX2 (2q31.1) / AFAP1-AS1 (4p16.1)MTX2 (2q31.1) / KIAA1715 (2q31.1)MTX2 (2q31.1) / MTX2 (2q31.1)
MTX2 (2q31.1) / RPL8 (8q24.3)PLEKHA3 (2q31.2) / MTX2 (2q31.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)MTX2   7506
Cards
Entrez_Gene (NCBI)MTX2  10651  metaxin 2
Aliases
GeneCards (Weizmann)MTX2
Ensembl hg19 (Hinxton)ENSG00000128654 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000128654 [Gene_View]  chr2:176269395-176338025 [Contig_View]  MTX2 [Vega]
ICGC DataPortalENSG00000128654
TCGA cBioPortalMTX2
AceView (NCBI)MTX2
Genatlas (Paris)MTX2
WikiGenes10651
SOURCE (Princeton)MTX2
Genetics Home Reference (NIH)MTX2
Genomic and cartography
GoldenPath hg38 (UCSC)MTX2  -     chr2:176269395-176338025 +  2q31.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MTX2  -     2q31.1   [Description]    (hg19-Feb_2009)
EnsemblMTX2 - 2q31.1 [CytoView hg19]  MTX2 - 2q31.1 [CytoView hg38]
Mapping of homologs : NCBIMTX2 [Mapview hg19]  MTX2 [Mapview hg38]
OMIM608555   
Gene and transcription
Genbank (Entrez)AF053551 AI991560 AK001287 AK289359 AK303564
RefSeq transcript (Entrez)NM_001006635 NM_001319097 NM_001319098 NM_006554
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)MTX2
Cluster EST : UnigeneHs.470728 [ NCBI ]
CGAP (NCI)Hs.470728
Alternative Splicing GalleryENSG00000128654
Gene ExpressionMTX2 [ NCBI-GEO ]   MTX2 [ EBI - ARRAY_EXPRESS ]   MTX2 [ SEEK ]   MTX2 [ MEM ]
Gene Expression Viewer (FireBrowse)MTX2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10651
GTEX Portal (Tissue expression)MTX2
Human Protein AtlasENSG00000128654-MTX2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO75431   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO75431  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO75431
Splice isoforms : SwissVarO75431
PhosPhoSitePlusO75431
Domains : Interpro (EBI)Glutathione-S-Trfase_C-like    Metaxin_GST    Sam37/metaxin_N   
Domain families : Pfam (Sanger)GST_C_6 (PF17171)    Tom37 (PF10568)   
Domain families : Pfam (NCBI)pfam17171    pfam10568   
Conserved Domain (NCBI)MTX2
DMDM Disease mutations10651
Blocks (Seattle)MTX2
SuperfamilyO75431
Human Protein Atlas [tissue]ENSG00000128654-MTX2 [tissue]
Peptide AtlasO75431
HPRD09777
IPIIPI00025717   IPI00477773   IPI00927198   IPI00925213   IPI00927437   IPI00927670   
Protein Interaction databases
DIP (DOE-UCLA)O75431
IntAct (EBI)O75431
FunCoupENSG00000128654
BioGRIDMTX2
STRING (EMBL)MTX2
ZODIACMTX2
Ontologies - Pathways
QuickGOO75431
Ontology : AmiGOprotein binding  nucleolus  mitochondrion  mitochondrial outer membrane  protein targeting to mitochondrion  mitochondrial transport  
Ontology : EGO-EBIprotein binding  nucleolus  mitochondrion  mitochondrial outer membrane  protein targeting to mitochondrion  mitochondrial transport  
NDEx NetworkMTX2
Atlas of Cancer Signalling NetworkMTX2
Wikipedia pathwaysMTX2
Orthology - Evolution
OrthoDB10651
GeneTree (enSembl)ENSG00000128654
Phylogenetic Trees/Animal Genes : TreeFamMTX2
HOVERGENO75431
HOGENOMO75431
Homologs : HomoloGeneMTX2
Homology/Alignments : Family Browser (UCSC)MTX2
Gene fusions - Rearrangements
Fusion: Tumor Portal MTX2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMTX2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MTX2
dbVarMTX2
ClinVarMTX2
1000_GenomesMTX2 
Exome Variant ServerMTX2
ExAC (Exome Aggregation Consortium)ENSG00000128654
GNOMAD BrowserENSG00000128654
Genetic variants : HAPMAP10651
Genomic Variants (DGV)MTX2 [DGVbeta]
DECIPHERMTX2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMTX2 
Mutations
ICGC Data PortalMTX2 
TCGA Data PortalMTX2 
Broad Tumor PortalMTX2
OASIS PortalMTX2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMTX2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDMTX2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch MTX2
DgiDB (Drug Gene Interaction Database)MTX2
DoCM (Curated mutations)MTX2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MTX2 (select a term)
intoGenMTX2
Cancer3DMTX2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM608555   
Orphanet
MedgenMTX2
Genetic Testing Registry MTX2
NextProtO75431 [Medical]
TSGene10651
GENETestsMTX2
Target ValidationMTX2
Huge Navigator MTX2 [HugePedia]
snp3D : Map Gene to Disease10651
BioCentury BCIQMTX2
ClinGenMTX2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD10651
Chemical/Pharm GKB GenePA31308
Clinical trialMTX2
Miscellaneous
canSAR (ICR)MTX2 (select the gene name)
Probes
Litterature
PubMed20 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMTX2
EVEXMTX2
GoPubMedMTX2
iHOPMTX2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Nov 9 12:18:15 CET 2017

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