MUC15 (mucin 15, cell surface associated)

2009-09-01  

Identity

HGNC
LOCATION
11p14.2
LOCUSID
ALIAS
MUC-15,PAS3,PASIII

Other Information

Locus ID:

NCBI: 143662
MIM: 608566
HGNC: 14956
Ensembl: ENSG00000169550

Variants:

dbSNP: 143662
ClinVar: 143662
TCGA: ENSG00000169550
COSMIC: MUC15

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000169550ENST00000281268A0A0A0MTD6
ENSG00000169550ENST00000436318A0A0A0MT67
ENSG00000169550ENST00000455601Q8N387
ENSG00000169550ENST00000527569A0A0A0MTD6
ENSG00000169550ENST00000529533A0A0A0MT67
ENSG00000169550ENST00000648230A0A3B3IU37

Expression (GTEx)

0
10
20
30
40
50
60
70

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
O-linked glycosylationREACTOMER-HSA-5173105
O-linked glycosylation of mucinsREACTOMER-HSA-913709
Termination of O-glycan biosynthesisREACTOMER-HSA-977068
DiseaseREACTOMER-HSA-1643685
Diseases of glycosylationREACTOMER-HSA-3781865
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
C-type lectin receptors (CLRs)REACTOMER-HSA-5621481
Dectin-2 familyREACTOMER-HSA-5621480
Diseases associated with O-glycosylation of proteinsREACTOMER-HSA-3906995
Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS)REACTOMER-HSA-5083632
Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC)REACTOMER-HSA-5083625
Defective GALNT12 causes colorectal cancer 1 (CRCS1)REACTOMER-HSA-5083636

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
239336032013MUC15 inhibits dimerization of EGFR and PI3K-AKT signaling and is associated with aggressive hepatocellular carcinomas in patients.39
177206982007Mucin 15 is expressed in human placenta and suppresses invasion of trophoblast-like cells in vitro.14
195207922009Overexpression of MUC15 activates extracellular signal-regulated kinase 1/2 and promotes the oncogenic potential of human colon cancer cells.14
216153022011Expression of the membrane mucins MUC4 and MUC15, potential markers of malignancy and prognosis, in papillary thyroid carcinoma.13
188340732008Mucin gene expression in human laryngeal epithelia: effect of laryngopharyngeal reflux.10
247109412014Correlations of MUC15 overexpression with clinicopathological features and prognosis of glioma.5
226574082012The ANO3/MUC15 locus is associated with eczema in families ascertained through asthma.2
255735892015Frameshift mutations of MUC15 gene in gastric and its regional heterogeneity in gastric and colorectal cancers.1

Citation

Dessen P

MUC15 (mucin 15, cell surface associated)

Atlas Genet Cytogenet Oncol Haematol. 2009-09-01

Online version: http://atlasgeneticsoncology.org/gene/51057/muc15