MUC21 (mucin 21, cell surface associated)

2014-08-01  

Identity

HGNC
LOCATION
6p21.33
LOCUSID
ALIAS
C6orf205,KMQK697,MUC-21
FUSION GENES

Other Information

Locus ID:

NCBI: 394263
MIM: 616991
HGNC: 21661
Ensembl: ENSG00000204544

Variants:

dbSNP: 394263
ClinVar: 394263
TCGA: ENSG00000204544
COSMIC: MUC21

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000204544ENST00000376296Q5SSG8
ENSG00000204544ENST00000486149A0A0C4DGM6

Expression (GTEx)

0
100
200
300
400
500
600
700
800
900
1000

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
O-linked glycosylationREACTOMER-HSA-5173105
O-linked glycosylation of mucinsREACTOMER-HSA-913709
Termination of O-glycan biosynthesisREACTOMER-HSA-977068
DiseaseREACTOMER-HSA-1643685
Diseases of glycosylationREACTOMER-HSA-3781865
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
C-type lectin receptors (CLRs)REACTOMER-HSA-5621481
Dectin-2 familyREACTOMER-HSA-5621480
Diseases associated with O-glycosylation of proteinsREACTOMER-HSA-3906995
Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS)REACTOMER-HSA-5083632
Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC)REACTOMER-HSA-5083625
Defective GALNT12 causes colorectal cancer 1 (CRCS1)REACTOMER-HSA-5083636

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
198514452009High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions.51
280052672017Human gingiva transcriptome during wound healing.6
179779042008Identification and expression of human epiglycanin/MUC21: a novel transmembrane mucin.0
203887072010Mucin 21/epiglycanin modulates cell adhesion.0
278030532017Polymorphisms in microRNA binding sites of mucin genes as predictors of clinical outcome in colorectal cancer patients.0
303291652019Mucin 21 is a novel, negative immunohistochemical marker for epithelioid mesothelioma for its differentiation from lung adenocarcinoma.0
309739162019Specific expression of MUC21 in micropapillary elements of lung adenocarcinomas - Implications for the progression of EGFR-mutated lung adenocarcinomas.0

Citation

Dessen P

MUC21 (mucin 21, cell surface associated)

Atlas Genet Cytogenet Oncol Haematol. 2014-08-01

Online version: http://atlasgeneticsoncology.org/gene/54480/muc21