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MUC5B (mucin 5B, oligomeric mucus/gel-forming)

Identity

Alias_namesMUC5
mucin 5
Alias_symbol (synonym)MG1
Other aliasMUC-5B
MUC9
HGNC (Hugo) MUC5B
LocusID (NCBI) 727897
Atlas_Id 41461
Location 11p15.5  [Link to chromosome band 11p15]
Location_base_pair Starts at 1223065 and ends at 1262176 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
GHITM (10q23.1) / MUC5B (11p15.5)MUC5B (11p15.5) / FN1 (2q35)MUC5B (11p15.5) / MLEC (12q24.31)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)MUC5B   7516
Cards
Entrez_Gene (NCBI)MUC5B  727897  mucin 5B, oligomeric mucus/gel-forming
AliasesMG1; MUC-5B; MUC5; MUC9
GeneCards (Weizmann)MUC5B
Ensembl hg19 (Hinxton)ENSG00000117983 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000117983 [Gene_View]  ENSG00000117983 [Sequence]  chr11:1223065-1262176 [Contig_View]  MUC5B [Vega]
ICGC DataPortalENSG00000117983
TCGA cBioPortalMUC5B
AceView (NCBI)MUC5B
Genatlas (Paris)MUC5B
WikiGenes727897
SOURCE (Princeton)MUC5B
Genetics Home Reference (NIH)MUC5B
Genomic and cartography
GoldenPath hg38 (UCSC)MUC5B  -     chr11:1223065-1262176 +  11p15.5   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MUC5B  -     11p15.5   [Description]    (hg19-Feb_2009)
GoldenPathMUC5B - 11p15.5 [CytoView hg19]  MUC5B - 11p15.5 [CytoView hg38]
ImmunoBaseENSG00000117983
Mapping of homologs : NCBIMUC5B [Mapview hg19]  MUC5B [Mapview hg38]
OMIM178500   600770   
Gene and transcription
Genbank (Entrez)AA577624 AF086604 AF253321 AK303892 AK310939
RefSeq transcript (Entrez)NM_002458
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)MUC5B
Cluster EST : UnigeneHs.523395 [ NCBI ]
CGAP (NCI)Hs.523395
Alternative Splicing GalleryENSG00000117983
Gene ExpressionMUC5B [ NCBI-GEO ]   MUC5B [ EBI - ARRAY_EXPRESS ]   MUC5B [ SEEK ]   MUC5B [ MEM ]
Gene Expression Viewer (FireBrowse)MUC5B [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)727897
GTEX Portal (Tissue expression)MUC5B
Human Protein AtlasENSG00000117983-MUC5B [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9HC84   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9HC84  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9HC84
Splice isoforms : SwissVarQ9HC84
PhosPhoSitePlusQ9HC84
Domaine pattern : Prosite (Expaxy)CTCK_1 (PS01185)    CTCK_2 (PS01225)    VWFC_1 (PS01208)    VWFC_2 (PS50184)    VWFD (PS51233)   
Domains : Interpro (EBI)Cys_knot_C    Ser_inhib-like_sf    TIL_dom    Unchr_dom_Cys-rich    VWF_dom    VWF_type-D    WxxW_domain   
Domain families : Pfam (Sanger)C8 (PF08742)    Mucin2_WxxW (PF13330)    TIL (PF01826)    VWC (PF00093)    VWD (PF00094)   
Domain families : Pfam (NCBI)pfam08742    pfam13330    pfam01826    pfam00093    pfam00094   
Domain families : Smart (EMBL)C8 (SM00832)  CT (SM00041)  VWC (SM00214)  VWC_out (SM00215)  VWD (SM00216)  
Conserved Domain (NCBI)MUC5B
DMDM Disease mutations727897
Blocks (Seattle)MUC5B
SuperfamilyQ9HC84
Human Protein Atlas [tissue]ENSG00000117983-MUC5B [tissue]
Peptide AtlasQ9HC84
IPIIPI00918002   IPI00855918   IPI01011189   IPI00816128   IPI00000924   IPI00000930   IPI00000931   IPI01019100   IPI00936444   IPI01009758   IPI00980227   IPI00978871   
Protein Interaction databases
DIP (DOE-UCLA)Q9HC84
IntAct (EBI)Q9HC84
FunCoupENSG00000117983
BioGRIDMUC5B
STRING (EMBL)MUC5B
ZODIACMUC5B
Ontologies - Pathways
QuickGOQ9HC84
Ontology : AmiGOstimulatory C-type lectin receptor signaling pathway  protein binding  extracellular space  Golgi lumen  plasma membrane  O-glycan processing  intracellular membrane-bounded organelle  extracellular exosome  
Ontology : EGO-EBIstimulatory C-type lectin receptor signaling pathway  protein binding  extracellular space  Golgi lumen  plasma membrane  O-glycan processing  intracellular membrane-bounded organelle  extracellular exosome  
Pathways : KEGGSalivary secretion   
NDEx NetworkMUC5B
Atlas of Cancer Signalling NetworkMUC5B
Wikipedia pathwaysMUC5B
Orthology - Evolution
OrthoDB727897
GeneTree (enSembl)ENSG00000117983
Phylogenetic Trees/Animal Genes : TreeFamMUC5B
HOGENOMQ9HC84
Homologs : HomoloGeneMUC5B
Homology/Alignments : Family Browser (UCSC)MUC5B
Gene fusions - Rearrangements
Fusion Cancer (Beijing)MUC5B [11p15.5]  -  FN1 [2q35]  [FUSC002173]
Fusion : QuiverMUC5B
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMUC5B [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MUC5B
dbVarMUC5B
ClinVarMUC5B
1000_GenomesMUC5B 
Exome Variant ServerMUC5B
ExAC (Exome Aggregation Consortium)ENSG00000117983
GNOMAD BrowserENSG00000117983
Varsome BrowserMUC5B
Genetic variants : HAPMAP727897
Genomic Variants (DGV)MUC5B [DGVbeta]
DECIPHERMUC5B [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMUC5B 
Mutations
ICGC Data PortalMUC5B 
TCGA Data PortalMUC5B 
Broad Tumor PortalMUC5B
OASIS PortalMUC5B [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMUC5B  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDMUC5B
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch MUC5B
DgiDB (Drug Gene Interaction Database)MUC5B
DoCM (Curated mutations)MUC5B (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MUC5B (select a term)
intoGenMUC5B
Cancer3DMUC5B(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM178500    600770   
Orphanet17929    7029   
DisGeNETMUC5B
MedgenMUC5B
Genetic Testing Registry MUC5B
NextProtQ9HC84 [Medical]
TSGene727897
GENETestsMUC5B
Target ValidationMUC5B
Huge Navigator MUC5B [HugePedia]
snp3D : Map Gene to Disease727897
BioCentury BCIQMUC5B
ClinGenMUC5B
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD727897
Chemical/Pharm GKB GenePA31321
Clinical trialMUC5B
Miscellaneous
canSAR (ICR)MUC5B (select the gene name)
DataMed IndexMUC5B
Probes
Litterature
PubMed153 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMUC5B
EVEXMUC5B
GoPubMedMUC5B
iHOPMUC5B
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Jul 8 11:31:49 CEST 2019
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