MUC7 (mucin 7, secreted)

2011-10-01 Affiliation

Identity

HGNC

MUC7

LOCATION

4q13.3

LOCUSID

4589

ALIAS

MG2

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 4589
MIM: 158375
HGNC: 7518
Ensembl: ENSG00000171195

Variants:

dbSNP: 4589
ClinVar: 4589
TCGA: ENSG00000171195
COSMIC: MUC7

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000171195	ENST00000304887	Q8TAX7
ENSG00000171195	ENST00000413702	Q8TAX7
ENSG00000171195	ENST00000456088	Q8TAX7
ENSG00000171195	ENST00000505411	D6RHX1

Expression (GTEx)

5000

10000

15000

20000

25000

30000

35000

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Salivary secretion	KEGG	ko04970
Salivary secretion	KEGG	hsa04970
Metabolism of proteins	REACTOME	R-HSA-392499
Post-translational protein modification	REACTOME	R-HSA-597592
O-linked glycosylation	REACTOME	R-HSA-5173105
O-linked glycosylation of mucins	REACTOME	R-HSA-913709
Termination of O-glycan biosynthesis	REACTOME	R-HSA-977068
Disease	REACTOME	R-HSA-1643685
Diseases of glycosylation	REACTOME	R-HSA-3781865
Immune System	REACTOME	R-HSA-168256
Innate Immune System	REACTOME	R-HSA-168249
C-type lectin receptors (CLRs)	REACTOME	R-HSA-5621481
Dectin-2 family	REACTOME	R-HSA-5621480
Diseases associated with O-glycosylation of proteins	REACTOME	R-HSA-3906995
Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS)	REACTOME	R-HSA-5083632
Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC)	REACTOME	R-HSA-5083625
Defective GALNT12 causes colorectal cancer 1 (CRCS1)	REACTOME	R-HSA-5083636

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
17703412	2007	Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes.	100
15731026	2005	The StcE protease contributes to intimate adherence of enterohemorrhagic Escherichia coli O157:H7 to host cells.	51
15501816	2004	Streptococcus mutans surface alpha-enolase binds salivary mucin MG2 and human plasminogen.	39
19247692	2009	Analyses of associations with asthma in four asthma population samples from Canada and Australia.	39
19258923	2009	Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm children is associated with airway remodeling genes and innate immune genes.	26
11996097	2000	Structure and biosynthesis of human salivary mucins.	23
21647207	2011	Mucin expression pattern in pancreatic diseases: findings from EUS-guided fine-needle aspiration biopsies.	22
11378823	2001	Genetic polymorphism of MUC7: allele frequencies and association with asthma.	20
12543672	2003	MUC7 20-Mer: investigation of antimicrobial activity, secondary structure, and possible mechanism of antifungal action.	19
19423540	2009	Common variation in genes related to innate immunity and risk of adult glioma.	19

Citation

Dessen P

MUC7 (mucin 7, secreted)

Atlas Genet Cytogenet Oncol Haematol. 2011-10-01

Online version: http://atlasgeneticsoncology.org/gene/52448/muc7