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MUL1 (mitochondrial E3 ubiquitin protein ligase 1)

Identity

Alias_namesC1orf166
chromosome 1 open reading frame 166
Alias_symbol (synonym)FLJ12875
MULAN
RNF218
MAPL
GIDE
Other alias
HGNC (Hugo) MUL1
LocusID (NCBI) 79594
Atlas_Id 56405
Location 1p36.12  [Link to chromosome band 1p36]
Location_base_pair Starts at 20499448 and ends at 20508181 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
MEGF6 (1p36.32) / MUL1 (1p36.12)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)MUL1   25762
Cards
Entrez_Gene (NCBI)MUL1  79594  mitochondrial E3 ubiquitin protein ligase 1
AliasesC1orf166; GIDE; MAPL; MULAN; 
RNF218
GeneCards (Weizmann)MUL1
Ensembl hg19 (Hinxton)ENSG00000090432 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000090432 [Gene_View]  chr1:20499448-20508181 [Contig_View]  MUL1 [Vega]
ICGC DataPortalENSG00000090432
TCGA cBioPortalMUL1
AceView (NCBI)MUL1
Genatlas (Paris)MUL1
WikiGenes79594
SOURCE (Princeton)MUL1
Genetics Home Reference (NIH)MUL1
Genomic and cartography
GoldenPath hg38 (UCSC)MUL1  -     chr1:20499448-20508181 -  1p36.12   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MUL1  -     1p36.12   [Description]    (hg19-Feb_2009)
EnsemblMUL1 - 1p36.12 [CytoView hg19]  MUL1 - 1p36.12 [CytoView hg38]
Mapping of homologs : NCBIMUL1 [Mapview hg19]  MUL1 [Mapview hg38]
OMIM612037   
Gene and transcription
Genbank (Entrez)AB097015 AK022937 AK293430 AK303820 AL833889
RefSeq transcript (Entrez)NM_024544
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)MUL1
Cluster EST : UnigeneHs.10101 [ NCBI ]
CGAP (NCI)Hs.10101
Alternative Splicing GalleryENSG00000090432
Gene ExpressionMUL1 [ NCBI-GEO ]   MUL1 [ EBI - ARRAY_EXPRESS ]   MUL1 [ SEEK ]   MUL1 [ MEM ]
Gene Expression Viewer (FireBrowse)MUL1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)79594
GTEX Portal (Tissue expression)MUL1
Human Protein AtlasENSG00000090432-MUL1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ969V5   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ969V5  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ969V5
Splice isoforms : SwissVarQ969V5
Catalytic activity : Enzyme2.3.2.27 [ Enzyme-Expasy ]   2.3.2.272.3.2.27 [ IntEnz-EBI ]   2.3.2.27 [ BRENDA ]   2.3.2.27 [ KEGG ]   
PhosPhoSitePlusQ969V5
Domaine pattern : Prosite (Expaxy)ZF_RING_2 (PS50089)   
Domains : Interpro (EBI)GIDE    Znf_RING    Znf_RING/FYVE/PHD   
Domain families : Pfam (Sanger)GIDE (PF12483)   
Domain families : Pfam (NCBI)pfam12483   
Conserved Domain (NCBI)MUL1
DMDM Disease mutations79594
Blocks (Seattle)MUL1
SuperfamilyQ969V5
Human Protein Atlas [tissue]ENSG00000090432-MUL1 [tissue]
Peptide AtlasQ969V5
HPRD07799
IPIIPI00470595   
Protein Interaction databases
DIP (DOE-UCLA)Q969V5
IntAct (EBI)Q969V5
FunCoupENSG00000090432
BioGRIDMUL1
STRING (EMBL)MUL1
ZODIACMUL1
Ontologies - Pathways
QuickGOQ969V5
Ontology : AmiGOmitochondrial fission  ubiquitin-protein transferase activity  signal transducer activity  protein binding  mitochondrion  mitochondrion  peroxisome  apoptotic process  activation of cysteine-type endopeptidase activity involved in apoptotic process  activation of JUN kinase activity  zinc ion binding  negative regulation of mitochondrial fusion  regulation of mitochondrion organization  membrane  protein ubiquitination  protein ubiquitination  protein sumoylation  SUMO transferase activity  negative regulation of cell growth  axon  integral component of mitochondrial outer membrane  ubiquitin protein ligase binding  protein destabilization  positive regulation of protein sumoylation  identical protein binding  neuronal cell body  positive regulation of I-kappaB kinase/NF-kappaB signaling  negative regulation of innate immune response  negative regulation of defense response to virus by host  protein stabilization  mitochondrion localization  regulation of mitochondrial membrane potential  negative regulation of protein kinase B signaling  negative regulation of type I interferon-mediated signaling pathway  cellular response to exogenous dsRNA  negative regulation of chemokine (C-C motif) ligand 5 production  positive regulation of mitochondrial fission  regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway  positive regulation of dendrite extension  positive regulation of mitophagy in response to mitochondrial depolarization  
Ontology : EGO-EBImitochondrial fission  ubiquitin-protein transferase activity  signal transducer activity  protein binding  mitochondrion  mitochondrion  peroxisome  apoptotic process  activation of cysteine-type endopeptidase activity involved in apoptotic process  activation of JUN kinase activity  zinc ion binding  negative regulation of mitochondrial fusion  regulation of mitochondrion organization  membrane  protein ubiquitination  protein ubiquitination  protein sumoylation  SUMO transferase activity  negative regulation of cell growth  axon  integral component of mitochondrial outer membrane  ubiquitin protein ligase binding  protein destabilization  positive regulation of protein sumoylation  identical protein binding  neuronal cell body  positive regulation of I-kappaB kinase/NF-kappaB signaling  negative regulation of innate immune response  negative regulation of defense response to virus by host  protein stabilization  mitochondrion localization  regulation of mitochondrial membrane potential  negative regulation of protein kinase B signaling  negative regulation of type I interferon-mediated signaling pathway  cellular response to exogenous dsRNA  negative regulation of chemokine (C-C motif) ligand 5 production  positive regulation of mitochondrial fission  regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway  positive regulation of dendrite extension  positive regulation of mitophagy in response to mitochondrial depolarization  
NDEx NetworkMUL1
Atlas of Cancer Signalling NetworkMUL1
Wikipedia pathwaysMUL1
Orthology - Evolution
OrthoDB79594
GeneTree (enSembl)ENSG00000090432
Phylogenetic Trees/Animal Genes : TreeFamMUL1
HOVERGENQ969V5
HOGENOMQ969V5
Homologs : HomoloGeneMUL1
Homology/Alignments : Family Browser (UCSC)MUL1
Gene fusions - Rearrangements
Tumor Fusion PortalMUL1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMUL1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MUL1
dbVarMUL1
ClinVarMUL1
1000_GenomesMUL1 
Exome Variant ServerMUL1
ExAC (Exome Aggregation Consortium)ENSG00000090432
GNOMAD BrowserENSG00000090432
Genetic variants : HAPMAP79594
Genomic Variants (DGV)MUL1 [DGVbeta]
DECIPHERMUL1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMUL1 
Mutations
ICGC Data PortalMUL1 
TCGA Data PortalMUL1 
Broad Tumor PortalMUL1
OASIS PortalMUL1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMUL1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDMUL1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch MUL1
DgiDB (Drug Gene Interaction Database)MUL1
DoCM (Curated mutations)MUL1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MUL1 (select a term)
intoGenMUL1
Cancer3DMUL1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM612037   
Orphanet
DisGeNETMUL1
MedgenMUL1
Genetic Testing Registry MUL1
NextProtQ969V5 [Medical]
TSGene79594
GENETestsMUL1
Target ValidationMUL1
Huge Navigator MUL1 [HugePedia]
snp3D : Map Gene to Disease79594
BioCentury BCIQMUL1
ClinGenMUL1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD79594
Chemical/Pharm GKB GenePA162396329
Clinical trialMUL1
Miscellaneous
canSAR (ICR)MUL1 (select the gene name)
Probes
Litterature
PubMed39 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMUL1
EVEXMUL1
GoPubMedMUL1
iHOPMUL1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Nov 21 14:25:06 CET 2017

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