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MUS81 (MUS81 structure-specific endonuclease subunit)

Identity

Alias_namesMUS81 endonuclease homolog (yeast)
MUS81 endonuclease homolog (S. cerevisiae)
Alias_symbol (synonym)FLJ44872
SLX3
Other alias
HGNC (Hugo) MUS81
LocusID (NCBI) 80198
Atlas_Id 42907
Location 11q13.1  [Link to chromosome band 11q13]
Location_base_pair Starts at 65627872 and ends at 65633914 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
MUS81 (11q13.1) / MUS81 (11q13.1)PDE9A (21q22.3) / MUS81 (11q13.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)MUS81   29814
Cards
Entrez_Gene (NCBI)MUS81  80198  MUS81 structure-specific endonuclease subunit
AliasesSLX3
GeneCards (Weizmann)MUS81
Ensembl hg19 (Hinxton)ENSG00000172732 [Gene_View]  chr11:65627872-65633914 [Contig_View]  MUS81 [Vega]
Ensembl hg38 (Hinxton)ENSG00000172732 [Gene_View]  chr11:65627872-65633914 [Contig_View]  MUS81 [Vega]
ICGC DataPortalENSG00000172732
TCGA cBioPortalMUS81
AceView (NCBI)MUS81
Genatlas (Paris)MUS81
WikiGenes80198
SOURCE (Princeton)MUS81
Genetics Home Reference (NIH)MUS81
Genomic and cartography
GoldenPath hg19 (UCSC)MUS81  -     chr11:65627872-65633914 +  11q13.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)MUS81  -     11q13.1   [Description]    (hg38-Dec_2013)
EnsemblMUS81 - 11q13.1 [CytoView hg19]  MUS81 - 11q13.1 [CytoView hg38]
Mapping of homologs : NCBIMUS81 [Mapview hg19]  MUS81 [Mapview hg38]
OMIM606591   
Gene and transcription
Genbank (Entrez)AF425646 AK024665 AK095326 AK126820 AK223564
RefSeq transcript (Entrez)NM_025128
RefSeq genomic (Entrez)NC_000011 NC_018922 NT_167190 NW_004929380
Consensus coding sequences : CCDS (NCBI)MUS81
Cluster EST : UnigeneHs.288798 [ NCBI ]
CGAP (NCI)Hs.288798
Alternative Splicing GalleryENSG00000172732
Gene ExpressionMUS81 [ NCBI-GEO ]   MUS81 [ EBI - ARRAY_EXPRESS ]   MUS81 [ SEEK ]   MUS81 [ MEM ]
Gene Expression Viewer (FireBrowse)MUS81 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)80198
GTEX Portal (Tissue expression)MUS81
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ96NY9   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ96NY9  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ96NY9
Splice isoforms : SwissVarQ96NY9
PhosPhoSitePlusQ96NY9
Domains : Interpro (EBI)DNA_pol_b-like_N    DNA_repair_nuc_XPF/helicase    ERCC4_domain    Hlx-hairpin-Hlx_DNA-bd_motif    PolB_N    Restrct_endonuc-II-like   
Domain families : Pfam (Sanger)ERCC4 (PF02732)   
Domain families : Pfam (NCBI)pfam02732   
Domain families : Smart (EMBL)ERCC4 (SM00891)  HhH1 (SM00278)  
Conserved Domain (NCBI)MUS81
DMDM Disease mutations80198
Blocks (Seattle)MUS81
PDB (SRS)2MC3    2ZIX    4P0P    4P0Q    4P0R    4P0S   
PDB (PDBSum)2MC3    2ZIX    4P0P    4P0Q    4P0R    4P0S   
PDB (IMB)2MC3    2ZIX    4P0P    4P0Q    4P0R    4P0S   
PDB (RSDB)2MC3    2ZIX    4P0P    4P0Q    4P0R    4P0S   
Structural Biology KnowledgeBase2MC3    2ZIX    4P0P    4P0Q    4P0R    4P0S   
SCOP (Structural Classification of Proteins)2MC3    2ZIX    4P0P    4P0Q    4P0R    4P0S   
CATH (Classification of proteins structures)2MC3    2ZIX    4P0P    4P0Q    4P0R    4P0S   
SuperfamilyQ96NY9
Human Protein AtlasENSG00000172732
Peptide AtlasQ96NY9
HPRD09419
IPIIPI00289454   IPI00470411   IPI00984384   IPI00985022   IPI00983727   IPI00983029   IPI00975986   IPI00976533   IPI00976659   
Protein Interaction databases
DIP (DOE-UCLA)Q96NY9
IntAct (EBI)Q96NY9
FunCoupENSG00000172732
BioGRIDMUS81
STRING (EMBL)MUS81
ZODIACMUS81
Ontologies - Pathways
QuickGOQ96NY9
Ontology : AmiGODNA catabolic process, endonucleolytic  DNA binding  endodeoxyribonuclease activity  protein binding  nucleus  nucleoplasm  nucleolus  DNA repair  DNA recombination  interstrand cross-link repair  metal ion binding  3'-flap endonuclease activity  response to intra-S DNA damage checkpoint signaling  
Ontology : EGO-EBIDNA catabolic process, endonucleolytic  DNA binding  endodeoxyribonuclease activity  protein binding  nucleus  nucleoplasm  nucleolus  DNA repair  DNA recombination  interstrand cross-link repair  metal ion binding  3'-flap endonuclease activity  response to intra-S DNA damage checkpoint signaling  
Pathways : KEGGHomologous recombination    Fanconi anemia pathway   
NDEx NetworkMUS81
Atlas of Cancer Signalling NetworkMUS81
Wikipedia pathwaysMUS81
Orthology - Evolution
OrthoDB80198
GeneTree (enSembl)ENSG00000172732
Phylogenetic Trees/Animal Genes : TreeFamMUS81
HOVERGENQ96NY9
HOGENOMQ96NY9
Homologs : HomoloGeneMUS81
Homology/Alignments : Family Browser (UCSC)MUS81
Gene fusions - Rearrangements
Fusion : MitelmanPDE9A/MUS81 [21q22.3/11q13.1]  [t(11;21)(q13;q22)]  
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMUS81 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MUS81
dbVarMUS81
ClinVarMUS81
1000_GenomesMUS81 
Exome Variant ServerMUS81
ExAC (Exome Aggregation Consortium)MUS81 (select the gene name)
Genetic variants : HAPMAP80198
Genomic Variants (DGV)MUS81 [DGVbeta]
DECIPHER (Syndromes)11:65627872-65633914  ENSG00000172732
CONAN: Copy Number AnalysisMUS81 
Mutations
ICGC Data PortalMUS81 
TCGA Data PortalMUS81 
Broad Tumor PortalMUS81
OASIS PortalMUS81 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMUS81  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDMUS81
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch MUS81
DgiDB (Drug Gene Interaction Database)MUS81
DoCM (Curated mutations)MUS81 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MUS81 (select a term)
intoGenMUS81
Cancer3DMUS81(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606591   
Orphanet
MedgenMUS81
Genetic Testing Registry MUS81
NextProtQ96NY9 [Medical]
TSGene80198
GENETestsMUS81
Huge Navigator MUS81 [HugePedia]
snp3D : Map Gene to Disease80198
BioCentury BCIQMUS81
ClinGenMUS81
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD80198
Chemical/Pharm GKB GenePA134881809
Clinical trialMUS81
Miscellaneous
canSAR (ICR)MUS81 (select the gene name)
Probes
Litterature
PubMed79 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMUS81
EVEXMUS81
GoPubMedMUS81
iHOPMUS81
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 13:17:43 CET 2017

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