Atlas of Genetics and Cytogenetics in Oncology and Haematology

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MVD (mevalonate diphosphate decarboxylase)

Identity

Alias (NCBI)FP17780
MDDase
MPD
POROK7
HGNC (Hugo) MVD
HGNC Alias symbMPD
HGNC Alias namemevalonate pyrophosphate decarboxylase
 diphosphomevalonate decarboxylase
HGNC Previous namemevalonate (diphospho) decarboxylase
LocusID (NCBI) 4597
Atlas_Id 56470
Location 16q24.2  [Link to chromosome band 16q24]
Location_base_pair Starts at 88651940 and ends at 88663091 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
KMT5C (19q13.42) / MVD (16q24.3)SARS (1p13.3) / MVD (16q24.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)MVD   7529
Cards
Entrez_Gene (NCBI)MVD    mevalonate diphosphate decarboxylase
AliasesFP17780; MDDase; MPD; POROK7
GeneCards (Weizmann)MVD
Ensembl hg19 (Hinxton)ENSG00000167508 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000167508 [Gene_View]  ENSG00000167508 [Sequence]  chr16:88651940-88663091 [Contig_View]  MVD [Vega]
ICGC DataPortalENSG00000167508
TCGA cBioPortalMVD
AceView (NCBI)MVD
Genatlas (Paris)MVD
SOURCE (Princeton)MVD
Genetics Home Reference (NIH)MVD
Genomic and cartography
GoldenPath hg38 (UCSC)MVD  -     chr16:88651940-88663091 -  16q24.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MVD  -     16q24.2   [Description]    (hg19-Feb_2009)
GoldenPathMVD - 16q24.2 [CytoView hg19]  MVD - 16q24.2 [CytoView hg38]
ImmunoBaseENSG00000167508
genome Data Viewer NCBIMVD [Mapview hg19]  
OMIM603236   614714   
Gene and transcription
Genbank (Entrez)AB209229 AY203927 BC000011 BI752043 BT006930
RefSeq transcript (Entrez)NM_002461
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)MVD
Alternative Splicing GalleryENSG00000167508
Gene ExpressionMVD [ NCBI-GEO ]   MVD [ EBI - ARRAY_EXPRESS ]   MVD [ SEEK ]   MVD [ MEM ]
Gene Expression Viewer (FireBrowse)MVD [ Firebrowse - Broad ]
GenevisibleExpression of MVD in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4597
GTEX Portal (Tissue expression)MVD
Human Protein AtlasENSG00000167508-MVD [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP53602   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP53602  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP53602
Splice isoforms : SwissVarP53602
PhosPhoSitePlusP53602
Domains : Interpro (EBI)GHMP_kinase_C_sf    GHMP_kinase_N_dom    Mev_decarb    Mev_diP_decarb    Mvd1_C    Ribosomal_S5_D2-typ_fold    Ribosomal_S5_D2-typ_fold_subgr   
Domain families : Pfam (Sanger)GHMP_kinases_N (PF00288)    MDD_C (PF18376)   
Domain families : Pfam (NCBI)pfam00288    pfam18376   
Conserved Domain (NCBI)MVD
Blocks (Seattle)MVD
PDB (RSDB)3D4J   
PDB Europe3D4J   
PDB (PDBSum)3D4J   
PDB (IMB)3D4J   
Structural Biology KnowledgeBase3D4J   
SCOP (Structural Classification of Proteins)3D4J   
CATH (Classification of proteins structures)3D4J   
SuperfamilyP53602
Human Protein Atlas [tissue]ENSG00000167508-MVD [tissue]
Peptide AtlasP53602
HPRD04454
IPIIPI00022745   IPI00556625   IPI00428750   
Protein Interaction databases
DIP (DOE-UCLA)P53602
IntAct (EBI)P53602
BioGRIDMVD
STRING (EMBL)MVD
ZODIACMVD
Ontologies - Pathways
QuickGOP53602
Ontology : AmiGOdiphosphomevalonate decarboxylase activity  diphosphomevalonate decarboxylase activity  ATP binding  peroxisome  cytosol  cytosol  cytosol  dolichyl diphosphate biosynthetic process  cholesterol biosynthetic process  cholesterol biosynthetic process  cholesterol biosynthetic process  positive regulation of cell population proliferation  isoprenoid biosynthetic process  isopentenyl diphosphate biosynthetic process, mevalonate pathway  Hsp70 protein binding  protein homodimerization activity  regulation of cholesterol biosynthetic process  
Ontology : EGO-EBIdiphosphomevalonate decarboxylase activity  diphosphomevalonate decarboxylase activity  ATP binding  peroxisome  cytosol  cytosol  cytosol  dolichyl diphosphate biosynthetic process  cholesterol biosynthetic process  cholesterol biosynthetic process  cholesterol biosynthetic process  positive regulation of cell population proliferation  isoprenoid biosynthetic process  isopentenyl diphosphate biosynthetic process, mevalonate pathway  Hsp70 protein binding  protein homodimerization activity  regulation of cholesterol biosynthetic process  
Pathways : KEGGTerpenoid backbone biosynthesis   
NDEx NetworkMVD
Atlas of Cancer Signalling NetworkMVD
Wikipedia pathwaysMVD
Orthology - Evolution
OrthoDB4597
GeneTree (enSembl)ENSG00000167508
Phylogenetic Trees/Animal Genes : TreeFamMVD
HOGENOMP53602
Homologs : HomoloGeneMVD
Homology/Alignments : Family Browser (UCSC)MVD
Gene fusions - Rearrangements
Fusion : QuiverMVD
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMVD [hg38]
dbVarMVD
ClinVarMVD
MonarchMVD
1000_GenomesMVD 
Exome Variant ServerMVD
GNOMAD BrowserENSG00000167508
Varsome BrowserMVD
Genomic Variants (DGV)MVD [DGVbeta]
DECIPHERMVD [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMVD 
Mutations
ICGC Data PortalMVD 
TCGA Data PortalMVD 
Broad Tumor PortalMVD
OASIS PortalMVD [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMVD  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DMVD
Mutations and Diseases : HGMDMVD
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch MVD
DgiDB (Drug Gene Interaction Database)MVD
DoCM (Curated mutations)MVD (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MVD (select a term)
intoGenMVD
Cancer3DMVD(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603236    614714   
Orphanet11178   
DisGeNETMVD
MedgenMVD
Genetic Testing Registry MVD
NextProtP53602 [Medical]
GENETestsMVD
Target ValidationMVD
Huge Navigator MVD [HugePedia]
ClinGenMVD
Clinical trials, drugs, therapy
MyCancerGenomeMVD
Protein Interactions : CTD
Pharm GKB GenePA31330
PharosP53602
Clinical trialMVD
Miscellaneous
canSAR (ICR)MVD (select the gene name)
HarmonizomeMVD
DataMed IndexMVD
Probes
Litterature
PubMed28 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXMVD
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Thu Mar 25 19:35:16 CET 2021
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