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MVD (mevalonate diphosphate decarboxylase)

Identity

Alias_namesmevalonate (diphospho) decarboxylase
Alias_symbol (synonym)MPD
Other aliasFP17780
MDDase
POROK7
HGNC (Hugo) MVD
LocusID (NCBI) 4597
Atlas_Id 56470
Location 16q24.2  [Link to chromosome band 16q24]
Location_base_pair Starts at 88651940 and ends at 88663149 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
KMT5C (19q13.42) / MVD (16q24.3)SARS (1p13.3) / MVD (16q24.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)MVD   7529
Cards
Entrez_Gene (NCBI)MVD  4597  mevalonate diphosphate decarboxylase
AliasesFP17780; MDDase; MPD; POROK7
GeneCards (Weizmann)MVD
Ensembl hg19 (Hinxton)ENSG00000167508 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000167508 [Gene_View]  chr16:88651940-88663149 [Contig_View]  MVD [Vega]
ICGC DataPortalENSG00000167508
TCGA cBioPortalMVD
AceView (NCBI)MVD
Genatlas (Paris)MVD
WikiGenes4597
SOURCE (Princeton)MVD
Genetics Home Reference (NIH)MVD
Genomic and cartography
GoldenPath hg38 (UCSC)MVD  -     chr16:88651940-88663149 -  16q24.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MVD  -     16q24.2   [Description]    (hg19-Feb_2009)
EnsemblMVD - 16q24.2 [CytoView hg19]  MVD - 16q24.2 [CytoView hg38]
Mapping of homologs : NCBIMVD [Mapview hg19]  MVD [Mapview hg38]
OMIM603236   614714   
Gene and transcription
Genbank (Entrez)AB209229 AY203927 BC000011 BI752043 BT006930
RefSeq transcript (Entrez)NM_002461
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)MVD
Cluster EST : UnigeneHs.252457 [ NCBI ]
CGAP (NCI)Hs.252457
Alternative Splicing GalleryENSG00000167508
Gene ExpressionMVD [ NCBI-GEO ]   MVD [ EBI - ARRAY_EXPRESS ]   MVD [ SEEK ]   MVD [ MEM ]
Gene Expression Viewer (FireBrowse)MVD [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4597
GTEX Portal (Tissue expression)MVD
Protein : pattern, domain, 3D structure
UniProt/SwissProtP53602   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP53602  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP53602
Splice isoforms : SwissVarP53602
Catalytic activity : Enzyme4.1.1.33 [ Enzyme-Expasy ]   4.1.1.334.1.1.33 [ IntEnz-EBI ]   4.1.1.33 [ BRENDA ]   4.1.1.33 [ KEGG ]   
PhosPhoSitePlusP53602
Domains : Interpro (EBI)GHMP_kinase_C_dom    GHMP_kinase_N_dom    Mev_decarb    Mev_diP_decarb    Ribosomal_S5_D2-typ_fold    Ribosomal_S5_D2-typ_fold_subgr   
Domain families : Pfam (Sanger)GHMP_kinases_N (PF00288)   
Domain families : Pfam (NCBI)pfam00288   
Conserved Domain (NCBI)MVD
DMDM Disease mutations4597
Blocks (Seattle)MVD
PDB (SRS)3D4J   
PDB (PDBSum)3D4J   
PDB (IMB)3D4J   
PDB (RSDB)3D4J   
Structural Biology KnowledgeBase3D4J   
SCOP (Structural Classification of Proteins)3D4J   
CATH (Classification of proteins structures)3D4J   
SuperfamilyP53602
Human Protein AtlasENSG00000167508
Peptide AtlasP53602
HPRD04454
IPIIPI00022745   IPI00556625   IPI00428750   
Protein Interaction databases
DIP (DOE-UCLA)P53602
IntAct (EBI)P53602
FunCoupENSG00000167508
BioGRIDMVD
STRING (EMBL)MVD
ZODIACMVD
Ontologies - Pathways
QuickGOP53602
Ontology : AmiGOdiphosphomevalonate decarboxylase activity  diphosphomevalonate decarboxylase activity  ATP binding  peroxisome  cytosol  cytosol  dolichyl diphosphate biosynthetic process  cholesterol biosynthetic process  cholesterol biosynthetic process  cholesterol biosynthetic process  positive regulation of cell proliferation  isoprenoid biosynthetic process  isopentenyl diphosphate biosynthetic process, mevalonate pathway  Hsp70 protein binding  protein homodimerization activity  
Ontology : EGO-EBIdiphosphomevalonate decarboxylase activity  diphosphomevalonate decarboxylase activity  ATP binding  peroxisome  cytosol  cytosol  dolichyl diphosphate biosynthetic process  cholesterol biosynthetic process  cholesterol biosynthetic process  cholesterol biosynthetic process  positive regulation of cell proliferation  isoprenoid biosynthetic process  isopentenyl diphosphate biosynthetic process, mevalonate pathway  Hsp70 protein binding  protein homodimerization activity  
Pathways : KEGGTerpenoid backbone biosynthesis   
NDEx NetworkMVD
Atlas of Cancer Signalling NetworkMVD
Wikipedia pathwaysMVD
Orthology - Evolution
OrthoDB4597
GeneTree (enSembl)ENSG00000167508
Phylogenetic Trees/Animal Genes : TreeFamMVD
HOVERGENP53602
HOGENOMP53602
Homologs : HomoloGeneMVD
Homology/Alignments : Family Browser (UCSC)MVD
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMVD [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MVD
dbVarMVD
ClinVarMVD
1000_GenomesMVD 
Exome Variant ServerMVD
ExAC (Exome Aggregation Consortium)MVD (select the gene name)
Genetic variants : HAPMAP4597
Genomic Variants (DGV)MVD [DGVbeta]
DECIPHERMVD [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMVD 
Mutations
ICGC Data PortalMVD 
TCGA Data PortalMVD 
Broad Tumor PortalMVD
OASIS PortalMVD [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMVD  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDMVD
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch MVD
DgiDB (Drug Gene Interaction Database)MVD
DoCM (Curated mutations)MVD (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MVD (select a term)
intoGenMVD
Cancer3DMVD(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603236    614714   
Orphanet11178   
MedgenMVD
Genetic Testing Registry MVD
NextProtP53602 [Medical]
TSGene4597
GENETestsMVD
Huge Navigator MVD [HugePedia]
snp3D : Map Gene to Disease4597
BioCentury BCIQMVD
ClinGenMVD
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD4597
Chemical/Pharm GKB GenePA31330
Clinical trialMVD
Miscellaneous
canSAR (ICR)MVD (select the gene name)
Probes
Litterature
PubMed18 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMVD
EVEXMVD
GoPubMedMVD
iHOPMVD
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri May 19 12:27:34 CEST 2017

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