Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

MX1 (MX dynamin like GTPase 1)

Identity

Alias_namesmyxovirus (influenza) resistance 1, homolog of murine (interferon-inducible protein p78)
myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)
Alias_symbol (synonym)IFI-78K
MxA
Other aliasIFI78
MX
HGNC (Hugo) MX1
LocusID (NCBI) 4599
Atlas_Id 51031
Location 21q22.3  [Link to chromosome band 21q22]
Location_base_pair Starts at 41420558 and ends at 41459214 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
MX1 (21q22.3) / FNBP1 (9q34.11)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)MX1   7532
Cards
Entrez_Gene (NCBI)MX1  4599  MX dynamin like GTPase 1
AliasesIFI-78K; IFI78; MX; MxA
GeneCards (Weizmann)MX1
Ensembl hg19 (Hinxton)ENSG00000157601 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000157601 [Gene_View]  chr21:41420558-41459214 [Contig_View]  MX1 [Vega]
ICGC DataPortalENSG00000157601
TCGA cBioPortalMX1
AceView (NCBI)MX1
Genatlas (Paris)MX1
WikiGenes4599
SOURCE (Princeton)MX1
Genetics Home Reference (NIH)MX1
Genomic and cartography
GoldenPath hg38 (UCSC)MX1  -     chr21:41420558-41459214 +  21q22.3   [DescripTion],/>    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MX1  -     21q22.3   [Description]    (hg19-Feb_2009)
EnsemblMX1 - 21q22.3 [CytoView hg19]  MX1 - 21q22.3 [CytoView hg38]
Mapping of homologs : NCBIMX1 [Mapview hg19]  MX1 [Mapview hg38]
OMIM147150   
Gene and transcription
Genbank (Entrez)A00209 AK093008 AK096355 AK225885 AK315465
RefSeq transcript (Entrez)NM_001144925 NM_001178046 NM_001282920 NM_002462
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)MX1
Cluster EST : UnigeneHs.517307 [ NCBI ]
CGAP (NCI)Hs.517307
Alternative Splicing GalleryENSG00000157601
Gene ExpressionMX1 [ NCBI-GEO ]   MX1 [ EBI - ARRAY_EXPRESS ]   MX1 [ SEEK ]   MX1 [ MEM ]
Gene Expression Viewer (FireBrowse)MX1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4599
GTEX Portal (Tissue expression)MX1
Human Protein AtlasENSG00000157601-MX1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP20591   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP20591  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP20591
Splice isoforms : SwissVarP20591
PhosPhoSitePlusP20591
Domaine pattern : Prosite (Expaxy)G_DYNAMIN_1 (PS00410)    G_DYNAMIN_2 (PS51718)    GED (PS51388)   
Domains : Interpro (EBI)Dynamin_central    Dynamin_GTPase    Dynamin_GTPase_CS    Dynamin_SF    G_DYNAMIN_dom    GED    GED_dom    P-loop_NTPase   
Domain families : Pfam (Sanger)Dynamin_M (PF01031)    Dynamin_N (PF00350)    GED (PF02212)   
Domain families : Pfam (NCBI)pfam01031    pfam00350    pfam02212   
Domain families : Smart (EMBL)DYNc (SM00053)  GED (SM00302)  
Conserved Domain (NCBI)MX1
DMDM Disease mutations4599
Blocks (Seattle)MX1
PDB (SRS)3LJB    3SZR    3ZYS    4P4S    4P4T    4P4U   
PDB (PDBSum)3LJB    3SZR    3ZYS    4P4S    4P4T    4P4U   
PDB (IMB)3LJB    3SZR    3ZYS    4P4S    4P4T    4P4U   
PDB (RSDB)3LJB    3SZR    3ZYS    4P4S    4P4T    4P4U   
Structural Biology KnowledgeBase3LJB    3SZR    3ZYS    4P4S    4P4T    4P4U   
SCOP (Structural Classification of Proteins)3LJB    3SZR    3ZYS    4P4S    4P4T    4P4U   
CATH (Classification of proteins structures)3LJB    3SZR    3ZYS    4P4S    4P4T    4P4U   
SuperfamilyP20591
Human Protein Atlas [tissue]ENSG00000157601-MX1 [tissue]
Peptide AtlasP20591
HPRD00919
IPIIPI00167949   IPI00794288   IPI00795289   IPI00793629   IPI00796515   IPI00794837   IPI00797610   IPI00798389   
Protein Interaction databases
DIP (DOE-UCLA)P20591
IntAct (EBI)P20591
FunCoupENSG00000157601
BioGRIDMX1
STRING (EMBL)MX1
ZODIACMX1
Ontologies - Pathways
QuickGOP20591
Ontology : AmiGOmitochondrial fission  dynamin family protein polymerization involved in mitochondrial fission  GTPase activity  protein binding  GTP binding  cytoplasm  endoplasmic reticulum membrane  cytosol  cytosol  apoptotic process  defense response  signal transduction  microtubule binding  response to virus  nuclear membrane  mitochondrial membrane  response to type I interferon  identical protein binding  negative regulation of viral genome replication  innate immune response  perinuclear region of cytoplasm  defense response to virus  type I interferon signaling pathway  membrane fusion  
Ontology : EGO-EBImitochondrial fission  dynamin family protein polymerization involved in mitochondrial fission  GTPase activity  protein binding  GTP binding  cytoplasm  endoplasmic reticulum membrane  cytosol  cytosol  apoptotic process  defense response  signal transduction  microtubule binding  response to virus  nuclear membrane  mitochondrial membrane  response to type I interferon  identical protein binding  negative regulation of viral genome replication  innate immune response  perinuclear region of cytoplasm  defense response to virus  type I interferon signaling pathway  membrane fusion  
Pathways : KEGGMeasles    Influenza A   
NDEx NetworkMX1
Atlas of Cancer Signalling NetworkMX1
Wikipedia pathwaysMX1
Orthology - Evolution
OrthoDB4599
GeneTree (enSembl)ENSG00000157601
Phylogenetic Trees/Animal Genes : TreeFamMX1
HOVERGENP20591
HOGENOMP20591
Homologs : HomoloGeneMX1
Homology/Alignments : Family Browser (UCSC)MX1
Gene fusions - Rearrangements
Tumor Fusion PortalMX1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMX1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MX1
dbVarMX1
ClinVarMX1
1000_GenomesMX1 
Exome Variant ServerMX1
ExAC (Exome Aggregation Consortium)ENSG00000157601
GNOMAD BrowserENSG00000157601
Genetic variants : HAPMAP4599
Genomic Variants (DGV)MX1 [DGVbeta]
DECIPHERMX1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMX1 
Mutations
ICGC Data PortalMX1 
TCGA Data PortalMX1 
Broad Tumor PortalMX1
OASIS PortalMX1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMX1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDMX1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch MX1
DgiDB (Drug Gene Interaction Database)MX1
DoCM (Curated mutations)MX1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MX1 (select a term)
intoGenMX1
Cancer3DMX1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM147150   
Orphanet
DisGeNETMX1
MedgenMX1
Genetic Testing Registry MX1
NextProtP20591 [Medical]
TSGene4599
GENETestsMX1
Target ValidationMX1
Huge Navigator MX1 [HugePedia]
snp3D : Map Gene to Disease4599
BioCentury BCIQMX1
ClinGenMX1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD4599
Chemical/Pharm GKB GenePA31333
Clinical trialMX1
Miscellaneous
canSAR (ICR)MX1 (select the gene name)
Probes
Litterature
PubMed169 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMX1
EVEXMX1
GoPubMedMX1
iHOPMX1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 21 14:25:08 CET 2017

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.