MX1 (MX dynamin like GTPase 1)

2009-08-01 Affiliation

Identity

HGNC

MX1

LOCATION

21q22.3

LOCUSID

4599

ALIAS

IFI-78K,IFI78,MX,MxA,lncMX1-215

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 4599
MIM: 147150
HGNC: 7532
Ensembl: ENSG00000157601

Variants:

dbSNP: 4599
ClinVar: 4599
TCGA: ENSG00000157601
COSMIC: MX1

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000157601	ENST00000288383	F8W8T1
ENSG00000157601	ENST00000398598	P20591
ENSG00000157601	ENST00000398600	P20591
ENSG00000157601	ENST00000413778	H9KVD0
ENSG00000157601	ENST00000417963	H9KVC9
ENSG00000157601	ENST00000419044	H9KVC3
ENSG00000157601	ENST00000424365	H9KVC7
ENSG00000157601	ENST00000427464	H9KVD3
ENSG00000157601	ENST00000441677	H9KVC4
ENSG00000157601	ENST00000455164	P20591
ENSG00000157601	ENST00000619682	P20591

Expression (GTEx)

100

150

200

250

300

350

400

450

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Measles	KEGG	ko05162
Measles	KEGG	hsa05162
Influenza A	KEGG	ko05164
Influenza A	KEGG	hsa05164
Immune System	REACTOME	R-HSA-168256
Cytokine Signaling in Immune system	REACTOME	R-HSA-1280215
Interferon Signaling	REACTOME	R-HSA-913531
Interferon alpha/beta signaling	REACTOME	R-HSA-909733
Antiviral mechanism by IFN-stimulated genes	REACTOME	R-HSA-1169410
ISG15 antiviral mechanism	REACTOME	R-HSA-1169408

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
21166595	2011	Human MxA protein: an interferon-induced dynamin-like GTPase with broad antiviral activity.	112
20428112	2010	Structural basis of oligomerization in the stalk region of dynamin-like MxA.	103
21962493	2011	Structure of myxovirus resistance protein a reveals intra- and intermolecular domain interactions required for the antiviral function.	80
12944978	2003	Polymorphisms in interferon-induced genes and the outcome of hepatitis C virus infection: roles of MxA, OAS-1 and PKR.	68
12944978	2003	Polymorphisms in interferon-induced genes and the outcome of hepatitis C virus infection: roles of MxA, OAS-1 and PKR.	68
23015724	2012	Interferon-inducible protein Mx1 inhibits influenza virus by interfering with functional viral ribonucleoprotein complex assembly.	64
14752052	2004	Nuclear MxA proteins form a complex with influenza virus NP and inhibit the transcription of the engineered influenza virus genome.	60
23084925	2012	Evolution-guided identification of antiviral specificity determinants in the broadly acting interferon-induced innate immunity factor MxA.	56
15766558	2005	Polymorphisms of interferon-inducible genes OAS-1 and MxA associated with SARS in the Vietnamese population.	47
15766558	2005	Polymorphisms of interferon-inducible genes OAS-1 and MxA associated with SARS in the Vietnamese population.	47

Citation

Dessen P

MX1 (MX dynamin like GTPase 1)

Atlas Genet Cytogenet Oncol Haematol. 2009-08-01

Online version: http://atlasgeneticsoncology.org/gene/51031/mx1