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MX2 (MX dynamin like GTPase 2)

Identity

Other aliasMXB
HGNC (Hugo) MX2
LocusID (NCBI) 4600
Atlas_Id 56797
Location 21q22.3  [Link to chromosome band 21q22]
Location_base_pair Starts at 41362023 and ends at 41408942 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CDKAL1 (6p22.3) / MX2 (21q22.3)MALAT1 (11q13.1) / MX2 (21q22.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)MX2   7533
Cards
Entrez_Gene (NCBI)MX2  4600  MX dynamin like GTPase 2
AliasesMXB
GeneCards (Weizmann)MX2
Ensembl hg19 (Hinxton) [Gene_View]
Ensembl hg38 (Hinxton) [Gene_View]  chr21:41362023-41408942 [Contig_View]  MX2 [Vega]
TCGA cBioPortalMX2
AceView (NCBI)MX2
Genatlas (Paris)MX2
WikiGenes4600
SOURCE (Princeton)MX2
Genetics Home Reference (NIH)MX2
Genomic and cartography
GoldenPath hg38 (UCSC)MX2  -     chr21:41362023-41408942 +  21q22.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MX2  -     21q22.3   [Description]    (hg19-Feb_2009)
EnsemblMX2 - 21q22.3 [CytoView hg19]  MX2 - 21q22.3 [CytoView hg38]
Mapping of homologs : NCBIMX2 [Mapview hg19]  MX2 [Mapview hg38]
OMIM147890   
Gene and transcription
Genbank (Entrez)AK122952 AK124336 AK127895 AK298780 AK308060
RefSeq transcript (Entrez)NM_002463
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)MX2
Cluster EST : UnigeneHs.926 [ NCBI ]
CGAP (NCI)Hs.926
Gene ExpressionMX2 [ NCBI-GEO ]   MX2 [ EBI - ARRAY_EXPRESS ]   MX2 [ SEEK ]   MX2 [ MEM ]
Gene Expression Viewer (FireBrowse)MX2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4600
GTEX Portal (Tissue expression)MX2
Protein : pattern, domain, 3D structure
UniProt/SwissProtP20592   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP20592  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP20592
Splice isoforms : SwissVarP20592
PhosPhoSitePlusP20592
Domaine pattern : Prosite (Expaxy)G_DYNAMIN_1 (PS00410)    G_DYNAMIN_2 (PS51718)    GED (PS51388)   
Domains : Interpro (EBI)Dynamin_central    Dynamin_GTPase    Dynamin_GTPase_CS    Dynamin_SF    G_DYNAMIN_dom    GED    GED_dom    P-loop_NTPase   
Domain families : Pfam (Sanger)Dynamin_M (PF01031)    Dynamin_N (PF00350)    GED (PF02212)   
Domain families : Pfam (NCBI)pfam01031    pfam00350    pfam02212   
Domain families : Smart (EMBL)DYNc (SM00053)  GED (SM00302)  
Conserved Domain (NCBI)MX2
DMDM Disease mutations4600
Blocks (Seattle)MX2
PDB (SRS)4WHJ    4X0R   
PDB (PDBSum)4WHJ    4X0R   
PDB (IMB)4WHJ    4X0R   
PDB (RSDB)4WHJ    4X0R   
Structural Biology KnowledgeBase4WHJ    4X0R   
SCOP (Structural Classification of Proteins)4WHJ    4X0R   
CATH (Classification of proteins structures)4WHJ    4X0R   
SuperfamilyP20592
Peptide AtlasP20592
IPIIPI00024684   IPI00791998   IPI01022689   IPI00790233   IPI00790849   IPI00791296   IPI01008878   
Protein Interaction databases
DIP (DOE-UCLA)P20592
IntAct (EBI)P20592
BioGRIDMX2
STRING (EMBL)MX2
ZODIACMX2
Ontologies - Pathways
QuickGOP20592
Ontology : AmiGOmitochondrial fission  dynamin family protein polymerization involved in mitochondrial fission  GTPase activity  protein binding  GTP binding  nucleus  nuclear pore  cytoplasm  cytosol  defense response  microtubule binding  response to virus  protein transport  mitochondrial membrane  response to interferon-alpha  innate immune response  regulation of nucleocytoplasmic transport  mRNA transport  defense response to virus  regulation of cell cycle  type I interferon signaling pathway  membrane fusion  
Ontology : EGO-EBImitochondrial fission  dynamin family protein polymerization involved in mitochondrial fission  GTPase activity  protein binding  GTP binding  nucleus  nuclear pore  cytoplasm  cytosol  defense response  microtubule binding  response to virus  protein transport  mitochondrial membrane  response to interferon-alpha  innate immune response  regulation of nucleocytoplasmic transport  mRNA transport  defense response to virus  regulation of cell cycle  type I interferon signaling pathway  membrane fusion  
NDEx NetworkMX2
Atlas of Cancer Signalling NetworkMX2
Wikipedia pathwaysMX2
Orthology - Evolution
OrthoDB4600
Phylogenetic Trees/Animal Genes : TreeFamMX2
HOVERGENP20592
HOGENOMP20592
Homologs : HomoloGeneMX2
Homology/Alignments : Family Browser (UCSC)MX2
Gene fusions - Rearrangements
Tumor Fusion PortalMX2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMX2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MX2
dbVarMX2
ClinVarMX2
1000_GenomesMX2 
Exome Variant ServerMX2
ExAC (Exome Aggregation Consortium)
Genetic variants : HAPMAP4600
Genomic Variants (DGV)MX2 [DGVbeta]
DECIPHERMX2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMX2 
Mutations
ICGC Data PortalMX2 
TCGA Data PortalMX2 
Broad Tumor PortalMX2
OASIS PortalMX2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMX2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDMX2
BioMutasearch MX2
DgiDB (Drug Gene Interaction Database)MX2
DoCM (Curated mutations)MX2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MX2 (select a term)
intoGenMX2
Cancer3DMX2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM147890   
Orphanet
DisGeNETMX2
MedgenMX2
Genetic Testing Registry MX2
NextProtP20592 [Medical]
TSGene4600
GENETestsMX2
Target ValidationMX2
Huge Navigator MX2 [HugePedia]
snp3D : Map Gene to Disease4600
BioCentury BCIQMX2
ClinGenMX2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD4600
Chemical/Pharm GKB GenePA31334
Clinical trialMX2
Miscellaneous
canSAR (ICR)MX2 (select the gene name)
Probes
Litterature
PubMed49 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMX2
EVEXMX2
GoPubMedMX2
iHOPMX2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Nov 21 14:25:08 CET 2017

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