Redefinition of the coding sequence of the MXI1 gene and identification of a polymorphic repeat in the 3' non-coding region that allows the detection of loss of heterozygosity of chromosome 10q25 in glioblastomas. |
Albarosa R, DiDonato S, Finocchiaro G |
Human genetics. 1995 ; 95 (6) : 709-711. |
PMID 7789959 |
|
Expression of MXI1, a Myc antagonist, is regulated by Sp1 and AP2. |
Benson LQ, Coon MR, Krueger LM, Han GC, Sarnaik AA, Wechsler DS |
The Journal of biological chemistry. 1999 ; 274 (40) : 28794-28802. |
PMID 10497252 |
|
Mutation of the MXI1 gene in prostate cancer. |
Eagle LR, Yin X, Brothman AR, Williams BJ, Atkin NB, Prochownik EV |
Nature genetics. 1995 ; 9 (3) : 249-255. |
PMID 7773287 |
|
No germline mutations in the dimerization domain of MXI1 in prostate cancer clusters. The CRC/BPG UK Familial Prostate Cancer Study Collaborators. Cancer Research Campaign/British Prostate Group. |
Edwards SM, Dearnaley DP, Ardern-Jones A, Hamoudi RA, Easton DF, Ford D, Shearer R, Dowe A, Eeles RA |
British journal of cancer. 1997 ; 76 (8) : 992-1000. |
PMID 9376279 |
|
Two MAD tails: what the recent knockouts of Mad1 and Mxi1 tell us about the MYC/MAX/MAD network. |
Foley KP, Eisenman RN |
Biochimica et biophysica acta. 1999 ; 1423 (3) : M37-M47. |
PMID 10382539 |
|
Point mutations of the Mxil gene are rare in prostate cancers. |
Kawamata N, Park D, Wilczynski S, Yokota J, Koeffler HP |
The Prostate. 1996 ; 29 (3) : 191-193. |
PMID 8827088 |
|
Microsatellite instability and deletion analysis of chromosome 10 in human prostate cancer. |
Lacombe L, Orlow I, Reuter VE, Fair WR, Dalbagni G, Zhang ZF, Cordon-Cardo C |
International journal of cancer. Journal international du cancer. 1996 ; 69 (2) : 110-113. |
PMID 8608977 |
|
Mxi1 is a repressor of the c-Myc promoter and reverses activation by USF. |
Lee TC, Ziff EB |
The Journal of biological chemistry. 1999 ; 274 (2) : 595-606. |
PMID 9872993 |
|
Repression by the Mad(Mxi1)-Sin3 complex. |
Schreiber-Agus N, DePinho RA |
BioEssays : news and reviews in molecular, cellular and developmental biology. 1998 ; 20 (10) : 808-818. |
PMID 9819568 |
|
Expression, regulation and polymorphism of the mxi1 genes. |
Shimizu E, Shirasawa H, Kodama K, Sato T, Simizu B |
Gene. 1996 ; 176 (1-2) : 45-48. |
PMID 8918230 |
|
MXI1, a putative tumor suppressor gene, suppresses growth of human glioblastoma cells. |
Wechsler DS, Shelly CA, Petroff CA, Dang CV |
Cancer research. 1997 ; 57 (21) : 4905-4912. |
PMID 9354456 |
|
Mxi1, a protein that specifically interacts with Max to bind Myc-Max recognition sites. |
Zervos AS, Gyuris J, Brent R |
Cell. 1993 ; 72 (2) : 223-232. |
PMID 8425219 |
|
| Nomenclature |
HGNC (Hugo) | MXI1 7534 |
| Cards |
Atlas | MXI1ID209 |
Entrez_Gene (NCBI) | MXI1 4601 MAX interactor 1, dimerization protein |
Aliases | MAD2; MXD2; MXI; bHLHc11 |
GeneCards (Weizmann) | MXI1 |
Ensembl hg19 (Hinxton) | ENSG00000119950 [Gene_View] |
Ensembl hg38 (Hinxton) | ENSG00000119950 [Gene_View]  ENSG00000119950 [Sequence] chr10:110207605-110287365 [Contig_View] MXI1 [Vega] |
ICGC DataPortal | ENSG00000119950 |
TCGA cBioPortal | MXI1 |
AceView (NCBI) | MXI1 |
Genatlas (Paris) | MXI1 |
WikiGenes | 4601 |
SOURCE (Princeton) | MXI1 |
Genetics Home Reference (NIH) | MXI1 |
| Genomic and cartography |
GoldenPath hg38 (UCSC) | MXI1 - chr10:110207605-110287365 + 10q25.2 [Description] (hg38-Dec_2013) |
GoldenPath hg19 (UCSC) | MXI1 - 10q25.2 [Description] (hg19-Feb_2009) |
GoldenPath | MXI1 - 10q25.2 [CytoView hg19] MXI1 - 10q25.2 [CytoView hg38] |
ImmunoBase | ENSG00000119950 |
Mapping of homologs : NCBI | MXI1 [Mapview hg19] MXI1 [Mapview hg38] |
OMIM | 176807 600020 |
| Gene and transcription |
Genbank (Entrez) | AA640393 AA854855 AI373426 AI580132 AK303949 |
RefSeq transcript (Entrez) | NM_001008541 NM_005962 NM_130439 |
RefSeq genomic (Entrez) | |
Consensus coding sequences : CCDS (NCBI) | MXI1 |
Cluster EST : Unigene | Hs.728542 [ NCBI ] |
CGAP (NCI) | Hs.728542 |
Alternative Splicing Gallery | ENSG00000119950 |
Gene Expression | MXI1 [ NCBI-GEO ] MXI1 [ EBI - ARRAY_EXPRESS ]
MXI1 [ SEEK ] MXI1 [ MEM ] |
Gene Expression Viewer (FireBrowse) | MXI1 [ Firebrowse - Broad ] |
SOURCE (Princeton) | Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60] |
Genevestigator | Expression in : [tissues]  [cell-lines]  [cancer]  [perturbations]   |
BioGPS (Tissue expression) | 4601 |
GTEX Portal (Tissue expression) | MXI1 |
Human Protein Atlas | ENSG00000119950-MXI1 [pathology] [cell] [tissue] |
| Protein : pattern, domain, 3D structure |
UniProt/SwissProt | P50539 [function] [subcellular_location] [family_and_domains] [pathology_and_biotech] [ptm_processing] [expression] [interaction] |
NextProt | P50539 [Sequence] [Exons] [Medical] [Publications] |
With graphics : InterPro | P50539 |
Splice isoforms : SwissVar | P50539 |
PhosPhoSitePlus | P50539 |
Domaine pattern : Prosite (Expaxy) | BHLH (PS50888) |
Domains : Interpro (EBI) | bHLH_dom HLH_DNA-bd_sf |
Domain families : Pfam (Sanger) | HLH (PF00010) |
Domain families : Pfam (NCBI) | pfam00010 |
Domain families : Smart (EMBL) | HLH (SM00353) |
Conserved Domain (NCBI) | MXI1 |
DMDM Disease mutations | 4601 |
Blocks (Seattle) | MXI1 |
Superfamily | P50539 |
Human Protein Atlas [tissue] | ENSG00000119950-MXI1 [tissue] |
Peptide Atlas | P50539 |
HPRD | 02486 |
IPI | IPI00301031 IPI00552166 IPI00107617 IPI00646509 IPI00643660 IPI00412717 IPI00642612 |
| Protein Interaction databases |
DIP (DOE-UCLA) | P50539 |
IntAct (EBI) | P50539 |
FunCoup | ENSG00000119950 |
BioGRID | MXI1 |
STRING (EMBL) | MXI1 |
ZODIAC | MXI1 |
| Ontologies - Pathways |
QuickGO | P50539 |
Ontology : AmiGO | negative regulation of transcription by RNA polymerase II RNA polymerase II regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription repressor activity, RNA polymerase II-specific DNA binding transcription corepressor activity protein binding nucleus nucleolus cytosol negative regulation of cell proliferation cytoplasmic sequestering of transcription factor protein dimerization activity RNA polymerase II transcription factor complex |
Ontology : EGO-EBI | negative regulation of transcription by RNA polymerase II RNA polymerase II regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription repressor activity, RNA polymerase II-specific DNA binding transcription corepressor activity protein binding nucleus nucleolus cytosol negative regulation of cell proliferation cytoplasmic sequestering of transcription factor protein dimerization activity RNA polymerase II transcription factor complex |
NDEx Network | MXI1 |
Atlas of Cancer Signalling Network | MXI1 |
Wikipedia pathways | MXI1 |
| Orthology - Evolution |
OrthoDB | 4601 |
GeneTree (enSembl) | ENSG00000119950 |
Phylogenetic Trees/Animal Genes : TreeFam | MXI1 |
HOGENOM | P50539 |
Homologs : HomoloGene | MXI1 |
Homology/Alignments : Family Browser (UCSC) | MXI1 |
| Gene fusions - Rearrangements |
Fusion : FusionGDB | 12470 22923 22924 22925 22926 22927 22928 27638 27976 34860 |
Fusion : Fusion_Hub | ADCY9--MXI1 AOC3--MXI1 ARFRP1--MXI1 ATG5--MXI1 BUB3--MXI1 C1ORF63--MXI1 CHST15--MXI1 CKS2--MXI1 CSTF3--MXI1 DNMT1--MXI1 DPM2--MXI1 EBF1--MXI1 ECE1--MXI1 EXD3--MXI1 FAM107B--MXI1 |
| FHL1--MXI1 GET4--MXI1 GPHN--MXI1 HIF1AN--MXI1 HNRNPU--MXI1 IGH@--MXI1 LBR--MXI1 MAGI1--MXI1 MAGI2--MXI1 MAPT--MXI1 MFSD3--MXI1 MPG--MXI1 MXI1--ADD3 MXI1--AFP MXI1--C10ORF57 |
| MXI1--CPEB3 MXI1--HIF1A MXI1--KLK3 MXI1--LAPTM5 MXI1--MXI1 MXI1--PEPD MXI1--PKM MXI1--SGMS1 MXI1--TCEAL3 MXI1--TXNL1 MXI1--UBE2G2 NOM1--MXI1 PFKFB3--MXI1 PHF15--MXI1 PLEC--MXI1 |
| PMEL--MXI1 POLR2F--MXI1 PPP1R12C--MXI1 SCUBE1--MXI1 SERINC2--MXI1 SH2B2--MXI1 SHOC2--MXI1 SMC3--MXI1 SRGAP1--MXI1 STAC2--MXI1 STOX2--MXI1 TGM2--MXI1 USP54--MXI1 WDR6--MXI1 ZEB2--MXI1 |
| ZNF174--MXI1 ZZZ3--MXI1 |
Fusion : Quiver | MXI1 |
| Polymorphisms : SNP and Copy number variants |
NCBI Variation Viewer | MXI1 [hg38] |
dbSNP Single Nucleotide Polymorphism (NCBI) | MXI1 |
dbVar | MXI1 |
ClinVar | MXI1 |
1000_Genomes | MXI1 |
Exome Variant Server | MXI1 |
ExAC (Exome Aggregation Consortium) | ENSG00000119950 |
GNOMAD Browser | ENSG00000119950 |
Varsome Browser | MXI1 |
Genetic variants : HAPMAP | 4601 |
Genomic Variants (DGV) | MXI1 [DGVbeta] |
DECIPHER | MXI1 [patients] [syndromes] [variants] [genes] |
CONAN: Copy Number Analysis | MXI1 |
| Mutations |
ICGC Data Portal | MXI1 |
TCGA Data Portal | MXI1 |
Broad Tumor Portal | MXI1 |
OASIS Portal | MXI1 [ Somatic mutations - Copy number] |
Somatic Mutations in Cancer : COSMIC | MXI1 [overview] [genome browser] [tissue] [distribution] |
Somatic Mutations in Cancer : COSMIC3D | MXI1 |
Mutations and Diseases : HGMD | MXI1 |
LOVD (Leiden Open Variation Database) | Whole genome datasets |
LOVD (Leiden Open Variation Database) | LOVD 3.0 shared installation |
BioMuta | search MXI1 |
DgiDB (Drug Gene Interaction Database) | MXI1 |
DoCM (Curated mutations) | MXI1 (select the gene name) |
CIViC (Clinical Interpretations of Variants in Cancer) | MXI1 (select a term) |
intoGen | MXI1 |
NCG5 (London) | MXI1 |
Cancer3D | MXI1(select the gene name) |
Impact of mutations | [PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser] |
| Diseases |
---|
OMIM | 176807 600020 |
Orphanet | |
DisGeNET | MXI1 |
Medgen | MXI1 |
Genetic Testing Registry | MXI1
|
NextProt | P50539 [Medical] |
TSGene | 4601 |
GENETests | MXI1 |
Target Validation | MXI1 |
Huge Navigator |
MXI1 [HugePedia] |
snp3D : Map Gene to Disease | 4601 |
BioCentury BCIQ | MXI1 |
ClinGen | MXI1 |
| Clinical trials, drugs, therapy |
---|
Chemical/Protein Interactions : CTD | 4601 |
Chemical/Pharm GKB Gene | PA31335 |
Clinical trial | MXI1 |
| Miscellaneous |
---|
canSAR (ICR) | MXI1 (select the gene name) |
DataMed Index | MXI1 |
| Probes |
---|
| Litterature |
---|
PubMed | 63 Pubmed reference(s) in Entrez |
GeneRIFs | Gene References Into Functions (Entrez) |
CoreMine | MXI1 |
EVEX | MXI1 |
GoPubMed | MXI1 |
iHOP | MXI1 |