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MYB (v-myb myeloblastosis viral oncogene homolog (avian))

Written2009-02Liang Zhao, Diwakar R Pattabiraman, Thomas J Gonda
Diamantina Institute for Cancer, Immunology, Metabolic Medicine, University of Queensland, Australia

(Note : for Links provided by Atlas : click)

Identity

Alias_namesv-myb avian myeloblastosis viral oncogene homolog
Alias_symbol (synonym)c-myb
Other aliasC-myb
Cmyb
OTTHUMP00000017258
c-myb10A_CDS
c-myb13A_CDS
c-myb14A_CDS
c-myb8B_CDS
c-myb_CDS
efg
HGNC (Hugo) MYB
LocusID (NCBI) 4602
Atlas_Id 41466
Location 6q23.3  [Link to chromosome band 6q23]
Location_base_pair Starts at 135181315 and ends at 135219173 bp from pter ( according to hg19-Feb_2009)  [Mapping MYB.png]
Local_order Centromere SGK1 - ALDH8A1 - HBS1L - MYB - AHI1 - PDE7B - FAM54A telomere.
Fusion genes
(updated 2016)
ACTG1 (17q25.3) / MYB (6q23.3)AHI1 (6q23.3) / MYB (6q23.3)AIM1 (6q21) / MYB (6q23.3)
DNAJC1 (10p12.31) / MYB (6q23.3)HEATR5B (2p22.2) / MYB (6q23.3)MAN1A1 (6q22.31) / MYB (6q23.3)
MCF2 (Xq27.1) / MYB (6q23.3)MNX1 (7q36.3) / MYB (6q23.3)MYB (6q23.3) / AHI1 (6q23.3)
MYB (6q23.3) / GATA1 (Xp11.23)MYB (6q23.3) / MAML2 (11q21)MYB (6q23.3) / MNX1 (7q36.3)
MYB (6q23.3) / NFIB (9p23)MYB (6q23.3) / PCDHGA1 (5q31.3)MYB (6q23.3) / PDCD1LG2 (9p24.1)
NFIB (9p23) / MYB (6q23.3)TRB () / MYB (6q23.3)

DNA/RNA

Note MYB was identified as the cellular homologue of v-myb, an oncogene found in two avian retroviruses (Avian Myeloblastosis Virus (AMV) and E26), which induce myeloblastic leukaemia and a mixed myeloid/erythroid leukaemia, respectively, in chickens.
 
Description The MYB gene spans 37.85 kb on the long arm of chromosome 6 and is transcribed in the centromere-to-telomere orientation.
Transcription Multiple splicing variants of ~2.9 to 3.6 kb encode a series of MYB proteins with identical DNA binding domains but unique C-terminal domains. The best characterized MYB variant is p89 with additional exon 9B.
The first intron contains an elongation attenuation region (Atn) which is important in regulating transcription of MYB.

Protein

 
Description The MYB protein consists of three distinct functional domains: an N-terminal helix-turn-helix (HTH)-type DNA binding domain (DBD), a centrally located trans-activation domain (TAD) and a C-terminal negative regulatory domain (NRD).
The DBD consists of three tandem 52 amino acid repeat termed R1, R2 and R3, which are involved in recognition and binding to the consensus sequence PyAACT/GG, known as the MYB binding site (MBS). MYB's trans-activation of its target genes requires the TAD. The NRD negatively regulates the trans-activating and transforming capacity of MYB. Several motifs within the NRD have been identified, including a Heptad Leucine Repeat (HLR) and a highly conserved EVES motif. Disruption of the HLR motif results in enhancement of MYB's trans-activating and transforming capacities. The EVES motif is also involved in negative regulation of MYB's activity by mediating interactions between the N-terminus and the C-terminus of the MYB protein.
MYB protein is subject to post-translational modifications, including ubiquitination, sumoylation, acetylation and phosphorylation.
Expression MYB is expressed predominantly in immature progenitor cells of all haemopoietic lineages and these levels decrease as the cells progress towards terminal differentiation, although in differentiated T cells, MYB can be up-regulated upon activation.
Besides the haemopoietic system, MYB expression is also detected in colonic crypts and neurogenic niches.
MYB is highly expressed in almost all leukaemias. Overexpression of MYB is also detected in some solid tumors, such as breast cancer and colon cancer.
Localisation MYB is localized to the nucleus.
Function MYB mostly operates as a transcriptional activator. It binds to its cognate binding site (MYB binding site MBS; consensus A/C A A C G/T G) on target genes and regulates their expression.
MYB is essential for the establishment of definitive haemopoiesis; as such, myb-/- mice die of anoxia by embryonic day 15. Conditional knockout mice have shown that myb is required at different stages of differentiation of the T and B lymphoid lineages. MYB is also reported to play a role in maintaining the haemopoietic stem cell pool. Interestingly, hypomorphic myb alleles result in an increase in platelet numbers in mouse models.
MYB is involved in maintaining the proliferation of progenitor cells. Knockdown of MYB in leukaemic cells and estrogen receptor positive breast cancer cells, where it is highly expressed, significantly slows down cell proliferation. Overexpressed or activated MYB suppresses normal differentiation and promotes leukaemic transformation. However, MYB also activates a number of haemopoietic-specific genes.
Homology The MYB gene family contains the other two closely related members, MYBL1 (also known as A-MYB) and MYBL2 (also known as B-MYB).
The DBD is highly conserved between mammalian, chicken and drosophila MYB proteins, as well as MYBL1 and MYBL2. The MYB DBD also shares homology with other proteins, such as telomeric repeat binding factor -1, -2 (TRF1, TRF2) and cyclin D binding myb-like transcription factor 1 (DMTF1).

Implicated in

Note
  
Entity T-cell acute lymphoblastic leukaemia
Disease Translocation involving MYB and the T-cell receptor beta (TCRbeta) locus t(6;7)(q23;q34) and somatic genomic duplications at the C-MYB locus.
Cytogenetics Molecular mapping of the chromosomal breakpoints show 2 discrete breakpoint clusters at 6q23.3: One located 5kb telomeric, 3' of the C-MYB gene, and the other 50kb more telomeric. Another gene (AHI1) was located in the vicinity of the t(6;7) breakpoints and was disrupted in some cases. In all cases, the translocation placed C-MYB in the vicinity of the TCRbeta regulatory sequence.
Oncogenesis The abnormal regulation of C-MYB expression in this case confers a block of differentiation and continued proliferative capacity leading to its oncogenicity.
  
  
Entity Acute myeloid leukaemia
Note MYB is over-expressed in most human acute myeloid and lymphoid leukaemias. Several studies using antisense oligonucleotides and dominant negative forms of MYB have shown that MYB activity is essential for continued proliferation of AML and CML cells. Also, AML and CML cells are more sensitive to inhibition of MYB than their normal counterparts.
  
  
Entity AML that have MYST3-linked abnormalities
Disease Genomic gain of the MYB locus.
Prognosis MYST3-linked AMLs have been shown to be associated with poor prognosis.
Oncogenesis A gain of the MYB locus at 6q23 was recurrently detected in AMLs that have MYST3-translocations. A consequent increase in MYB mRNA levels was also reported.
  
  
Entity Colorectal cancer
Prognosis MYB is over-expressed in >80% of colorectal cancers. MYB expression correlates with poor prognosis for patients with colorectal cancer.
Oncogenesis Robust mRNA expression and MYB mRNA amplifications were identified in colorectal cancer cell lines. Protein overexpression is a feature of these cell lines and primary cancers. Mutations in the first intron of MYB in the Atn region that regulates transcriptional elongation have been reported in some colorectal cancer cell lines and primary cancers.
  
  
Entity Breast cancers
Note MYB over-expression.
Prognosis Since Myb over-expression is closely related to estrogen receptor positivity in breast cancers, prognosis is generally positive. This is due to the less severe nature of ER+ breast tumours and the availability of established therapeutics.
Oncogenesis 64% of breast cancers express MYB, which also strongly correlates with ERalpha positivity.
  
  
Entity Breast cancer harboring BRCA1 mutations
Note MYB amplification is seen in 29% of tumours in women with BRCA1 mutations.
Disease MYB amplification.
  

Breakpoints

 

Bibliography

Viral myb oncogene encodes a sequence-specific DNA-binding activity.
Biedenkapp H, Borgmeyer U, Sippel AE, Klempnauer KH.
Nature. 1988 Oct 27;335(6193):835-7.
PMID 3185713
 
Suppressor screen in Mpl-/- mice: c-Myb mutation causes supraphysiological production of platelets in the absence of thrombopoietin signaling.
Carpinelli MR, Hilton DJ, Metcalf D, Antonchuk JL, Hyland CD, Mifsud SL, Di Rago L, Hilton AA, Willson TA, Roberts AW, Ramsay RG, Nicola NA, Alexander WS.
Proc Natl Acad Sci U S A. 2004 Apr 27;101(17):6553-8. Epub 2004 Apr 7.
PMID 15071178
 
The C-MYB locus is involved in chromosomal translocation and genomic duplications in human T-cell acute leukemia (T-ALL), the translocation defining a new T-ALL subtype in very young children.
Clappier E, Cuccuini W, Kalota A, Crinquette A, Cayuela JM, Dik WA, Langerak AW, Montpellier B, Nadel B, Walrafen P, Delattre O, Aurias A, Leblanc T, Dombret H, Gewirtz AM, Baruchel A, Sigaux F, Soulier J.
Blood. 2007 Aug 15;110(4):1251-61. Epub 2007 Apr 23.
PMID 17452517
 
Critical roles for c-Myb in hematopoietic progenitor cells.
Greig KT, Carotta S, Nutt SL.
Semin Immunol. 2008 Aug;20(4):247-56. Epub 2008 Jun 26. (REVIEW)
PMID 18585056
 
Strong association between c-myb and oestrogen-receptor expression in human breast cancer.
Guerin M, Sheng ZM, Andrieu N, Riou G.
Oncogene. 1990 Jan;5(1):131-5.
PMID 2181374
 
Mutations in the MYB intron I regulatory sequence increase transcription in colon cancers.
Hugo H, Cures A, Suraweera N, Drabsch Y, Purcell D, Mantamadiotis T, Phillips W, Dobrovic A, Zupi G, Gonda TJ, Iacopetta B, Ramsay RG.
Genes Chromosomes Cancer. 2006 Dec;45(12):1143-54.
PMID 16977606
 
How can oncogenic transcription factors cause cancer: a critical review of the myb story.
Introna M, Golay J.
Leukemia. 1999 Sep;13(9):1301-6. (REVIEW)
PMID 10482978
 
MYB oncogene amplification in hereditary BRCA1 breast cancer.
Kauraniemi P, Hedenfalk I, Persson K, Duggan DJ, Tanner M, Johannsson O, Olsson H, Trent JM, Isola J, Borg A.
Cancer Res. 2000 Oct 1;60(19):5323-8.
PMID 11034064
 
Genome profiling of acute myelomonocytic leukemia: alteration of the MYB locus in MYST3-linked cases
Murati A, Gervais C, Carbuccia N, Finetti P, Cervera N, Adelaide J, Struski S, Lippert E, Mugneret F, Tigaud I, Penther D, Bastard C, Poppe B, Speleman F, Baranger L, Luquet I, Cornillet-Lefebvre P, Nadal N, Nguyen-Khac F, Perot C, Olschwang S, Bertucci F, Chaffanet M, Lessard M, Mozziconacci MJ, Birnbaum D; Groupe Francophone de Cytogenetique Hematologique.
Leukemia. 2009 Jan;23(1):85-94. Epub 2008 Sep 25.
PMID 18818702
 
Alternative RNA splicing produces multiple forms of c-Myb with unique transcriptional activities.
O'Rourke JP, Ness SA.
Mol Cell Biol. 2008 Mar;28(6):2091-101. Epub 2008 Jan 14.
PMID 18195038
 
MYB function in normal and cancer cells.
Ramsay RG, Gonda TJ.
Nat Rev Cancer. 2008 Jul;8(7):523-34. (REVIEW)
PMID 18574464
 
Three new types of viral oncogene of cellular origin specific for haematopoietic cell transformation.
Roussel M, Saule S, Lagrou C, Rommens C, Beug H, Graf T, Stehelin D.
Nature. 1979 Oct 11;281(5731):452-5.
PMID 226888
 
Delineation of three functional domains of the transcriptional activator encoded by the c-myb protooncogene.
Sakura H, Kanei-Ishii C, Nagase T, Nakagoshi H, Gonda TJ, Ishii S.
Proc Natl Acad Sci U S A. 1989 Aug;86(15):5758-62.
PMID 2668947
 
c-Myb and p300 regulate hematopoietic stem cell proliferation and differentiation.
Sandberg ML, Sutton SE, Pletcher MT, Wiltshire T, Tarantino LM, Hogenesch JB, Cooke MP.
Dev Cell. 2005 Feb;8(2):153-66.
PMID 15691758
 
Expression of cellular homologues of retroviral onc genes in human hematopoietic cells.
Westin EH, Wong-Staal F, Gelmann EP, Dalla-Favera R, Papas TS, Lautenberger JA, Eva A, Reddy EP, Tronick SR, Aaronson SA, Gallo RC.
Proc Natl Acad Sci U S A. 1982 Apr;79(8):2490-4.
PMID 6283530
 

Citation

This paper should be referenced as such :
Zhao, L ; Pattabiraman, DR ; Gonda, TJ
MYB (v-myb myeloblastosis viral oncogene homolog (avian))
Atlas Genet Cytogenet Oncol Haematol. 2010;14(1):36-38.
Free journal version : [ pdf ]   [ DOI ]
On line version : http://AtlasGeneticsOncology.org/Genes/MYBID41466ch6q23.html


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 7 ]
  Acute basophilic leukemia::t(X;6)(p11;q23) MYB/GATA1
t(1;9)(p13;p12) PAX5/HIPK1
t(5;6)(q33;q23) CEP85L/PDGFRB
t(6;7)(q23;q34) TRB/MYB and AHI1
t(10;16)(q22;p13) KAT6B/CREBBP
t(20;21)(q13.2;q22.12) ZFP64/RUNX1
T-lineage acute lymphoblastic leukemia (T-ALL)


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 6 ]
  Colon: Colorectal adenocarcinoma
Breast: Ductal carcinoma
Male breast cancer
Head and Neck: Salivary gland tumors: an overview
Skin: Cylindroma
Head and Neck: Salivary gland tumors: Adenoid cystic carcinoma with t(6;9)(q23;p24) MYB/PDCD1LG2


External links

Nomenclature
HGNC (Hugo)MYB   7545
Cards
AtlasMYBID41466ch6q23
Entrez_Gene (NCBI)MYB  4602  MYB proto-oncogene, transcription factor
AliasesCmyb; c-myb; c-myb_CDS; efg
GeneCards (Weizmann)MYB
Ensembl hg19 (Hinxton)ENSG00000118513 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000118513 [Gene_View]  chr6:135181315-135219173 [Contig_View]  MYB [Vega]
ICGC DataPortalENSG00000118513
TCGA cBioPortalMYB
AceView (NCBI)MYB
Genatlas (Paris)MYB
WikiGenes4602
SOURCE (Princeton)MYB
Genetics Home Reference (NIH)MYB
Genomic and cartography
GoldenPath hg38 (UCSC)MYB  -     chr6:135181315-135219173 +  6q23.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MYB  -     6q23.3   [Description]    (hg19-Feb_2009)
EnsemblMYB - 6q23.3 [CytoView hg19]  MYB - 6q23.3 [CytoView hg38]
Mapping of homologs : NCBIMYB [Mapview hg19]  MYB [Mapview hg38]
OMIM189990   
Gene and transcription
Genbank (Entrez)###############################################################################################################################################################################################################################################################
RefSeq transcript (Entrez)NM_001130172 NM_001130173 NM_001161656 NM_001161657 NM_001161658 NM_001161659 NM_001161660 NM_005375
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)MYB
Cluster EST : UnigeneHs.626299 [ NCBI ]
CGAP (NCI)Hs.626299
Alternative Splicing GalleryENSG00000118513
Gene ExpressionMYB [ NCBI-GEO ]   MYB [ EBI - ARRAY_EXPRESS ]   MYB [ SEEK ]   MYB [ MEM ]
Gene Expression Viewer (FireBrowse)MYB [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4602
GTEX Portal (Tissue expression)MYB
Protein : pattern, domain, 3D structure
UniProt/SwissProtP10242   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP10242  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP10242
Splice isoforms : SwissVarP10242
PhosPhoSitePlusP10242
Domaine pattern : Prosite (Expaxy)HTH_MYB (PS51294)   
Domains : Interpro (EBI)C-myb_C    Homeobox-like    Myb_dom    SANT/Myb    Tscrpt_reg_Wos2-domain   
Domain families : Pfam (Sanger)Cmyb_C (PF09316)    LMSTEN (PF07988)    Myb_DNA-binding (PF00249)   
Domain families : Pfam (NCBI)pfam09316    pfam07988    pfam00249   
Domain families : Smart (EMBL)SANT (SM00717)  
Conserved Domain (NCBI)MYB
DMDM Disease mutations4602
Blocks (Seattle)MYB
SuperfamilyP10242
Human Protein AtlasENSG00000118513
Peptide AtlasP10242
HPRD01810
IPI###############################################################################################################################################################################################################################################################   
Protein Interaction databases
DIP (DOE-UCLA)P10242
IntAct (EBI)P10242
FunCoupENSG00000118513
BioGRIDMYB
STRING (EMBL)MYB
ZODIACMYB
Ontologies - Pathways
QuickGOP10242
Ontology : AmiGOnegative regulation of transcription from RNA polymerase II promoter  mitotic cell cycle  RNA polymerase II core promoter proximal region sequence-specific DNA binding  RNA polymerase II transcription factor activity, sequence-specific DNA binding  transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding  transcription factor activity, RNA polymerase II transcription factor recruiting  response to hypoxia  protein binding  nucleus  chromatin remodeling  regulation of transcription, DNA-templated  transcription from RNA polymerase II promoter  nuclear matrix  positive regulation of collagen biosynthetic process  positive regulation of neuron apoptotic process  positive regulation of T-helper cell differentiation  negative regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  positive regulation of transcription from RNA polymerase II promoter  positive regulation of transcription from RNA polymerase II promoter  positive regulation of smooth muscle cell proliferation  positive regulation of histone H3-K4 methylation  positive regulation of histone H3-K9 methylation  positive regulation of glial cell proliferation  cellular response to hydrogen peroxide  cellular response to retinoic acid  positive regulation of transforming growth factor beta production  positive regulation of hepatic stellate cell proliferation  positive regulation of hepatic stellate cell activation  positive regulation of testosterone secretion  
Ontology : EGO-EBInegative regulation of transcription from RNA polymerase II promoter  mitotic cell cycle  RNA polymerase II core promoter proximal region sequence-specific DNA binding  RNA polymerase II transcription factor activity, sequence-specific DNA binding  transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding  transcription factor activity, RNA polymerase II transcription factor recruiting  response to hypoxia  protein binding  nucleus  chromatin remodeling  regulation of transcription, DNA-templated  transcription from RNA polymerase II promoter  nuclear matrix  positive regulation of collagen biosynthetic process  positive regulation of neuron apoptotic process  positive regulation of T-helper cell differentiation  negative regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  positive regulation of transcription from RNA polymerase II promoter  positive regulation of transcription from RNA polymerase II promoter  positive regulation of smooth muscle cell proliferation  positive regulation of histone H3-K4 methylation  positive regulation of histone H3-K9 methylation  positive regulation of glial cell proliferation  cellular response to hydrogen peroxide  cellular response to retinoic acid  positive regulation of transforming growth factor beta production  positive regulation of hepatic stellate cell proliferation  positive regulation of hepatic stellate cell activation  positive regulation of testosterone secretion  
Pathways : KEGGPI3K-Akt signaling pathway    HTLV-I infection   
REACTOMEP10242 [protein]
REACTOME PathwaysR-HSA-983231 [pathway]   
NDEx NetworkMYB
Atlas of Cancer Signalling NetworkMYB
Wikipedia pathwaysMYB
Orthology - Evolution
OrthoDB4602
GeneTree (enSembl)ENSG00000118513
Phylogenetic Trees/Animal Genes : TreeFamMYB
HOVERGENP10242
HOGENOMP10242
Homologs : HomoloGeneMYB
Homology/Alignments : Family Browser (UCSC)MYB
Gene fusions - Rearrangements
Fusion : MitelmanAHI1/MYB [6q23.3/6q23.3]  [t(6;6)(q23;q23)]  
Fusion : MitelmanAIM1/MYB [6q21/6q23.3]  [t(6;6)(q21;q23)]  
Fusion : MitelmanHEATR5B/MYB [2p22.2/6q23.3]  [t(2;6)(p22;q23)]  
Fusion : MitelmanMAN1A1/MYB [6q22.31/6q23.3]  [del(6)(q22q23)]  
Fusion : MitelmanMYB/AHI1 [6q23.3/6q23.3]  [t(6;6)(q23;q23)]  
Fusion : MitelmanMYB/GATA1 [6q23.3/Xp11.23]  [t(X;6)(p11;q23)]  
Fusion : MitelmanMYB/MAML2 [6q23.3/11q21]  [t(6;11)(q23;q21)]  
Fusion : MitelmanMYB/MNX1 [6q23.3/7q36.3]  [t(6;7)(q23;q36)]  
Fusion : MitelmanMYB/NFIB [6q23.3/9p23]  [t(6;9)(q23;p22)]  
Fusion : MitelmanMYB/PCDHGA1 [6q23.3/5q31.3]  [t(5;6)(q31;q23)]  
Fusion : MitelmanMYB/PDCD1LG2 [6q23.3/9p24.1]  [t(6;9)(q23;p24)]  
Fusion : MitelmanTRB/MYB [-/6q23.3]  [dup(6)(q23q23)]  [t(6;7)(q23;q34)]  
Fusion : COSMICMYB [6q23.3]  -  NFIB [9p23]  [fusion_784]  [fusion_786]  [fusion_876]  [fusion_877]  [fusion_878]  [fusion_879]  [fusion_880]  
[fusion_881]  [fusion_883]  [fusion_884]  [fusion_885]  [fusion_886]  [fusion_887]  [fusion_888]  [fusion_890]  [fusion_891]  [fusion_892]  
Fusion : COSMICNFIB [9p23]  -  MYB [6q23.3]  [fusion_893]  
Fusion: TCGAAHI1 6q23.3 MYB 6q23.3 BRCA
Fusion: TCGAAIM1 6q21 MYB 6q23.3 BRCA
Fusion: TCGAHEATR5B 2p22.2 MYB 6q23.3 BRCA
Fusion: TCGAMYB 6q23.3 NFIB 9p23 BRCA
Fusion : TICdbMYB [6q23.3]  -  GATA1 [Xp11.23]
Fusion : TICdbMYB [6q23.3]  -  NFIB [9p23]
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMYB [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MYB
dbVarMYB
ClinVarMYB
1000_GenomesMYB 
Exome Variant ServerMYB
ExAC (Exome Aggregation Consortium)MYB (select the gene name)
Genetic variants : HAPMAP4602
Genomic Variants (DGV)MYB [DGVbeta]
DECIPHERMYB [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMYB 
Mutations
ICGC Data PortalMYB 
TCGA Data PortalMYB 
Broad Tumor PortalMYB
OASIS PortalMYB [ Somatic mutations - Copy number]
Cancer Gene: CensusMYB 
Somatic Mutations in Cancer : COSMICMYB  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDMYB
intOGen PortalMYB
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)The Globin Gene Server
BioMutasearch MYB
DgiDB (Drug Gene Interaction Database)MYB
DoCM (Curated mutations)MYB (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MYB (select a term)
intoGenMYB
NCG5 (London)MYB
Cancer3DMYB(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM189990   
Orphanet19674    11754    14434   
MedgenMYB
Genetic Testing Registry MYB
NextProtP10242 [Medical]
TSGene4602
GENETestsMYB
Target ValidationMYB
Huge Navigator MYB [HugePedia]
snp3D : Map Gene to Disease4602
BioCentury BCIQMYB
ClinGenMYB
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD4602
Chemical/Pharm GKB GenePA31345
Clinical trialMYB
Miscellaneous
canSAR (ICR)MYB (select the gene name)
Other databasehttp://cancergenome.broadinstitute.org/index.php?tgene=MYB
Probes
Litterature
PubMed253 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMYB
EVEXMYB
GoPubMedMYB
iHOPMYB
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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