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MYCBP2 (MYC binding protein 2)

Identity

Alias (NCBI)Myc-bp2
PAM
PHR1
Phr
HGNC (Hugo) MYCBP2
HGNC Alias symbPAM
KIAA0916
FLJ10106
PHR1
HGNC Alias namePAM/Highwire/RPM-1 protein 1
HGNC Previous nameMYC binding protein 2, E3 ubiquitin protein ligase
LocusID (NCBI) 23077
Atlas_Id 55356
Location 13q22.3  [Link to chromosome band 13q22]
Location_base_pair Starts at 77044657 and ends at 77327094 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
HIPK2 (7q34) / MYCBP2 (13q22.3)MYCBP2 (13q22.3) / ATG7 (3p25.3)MYCBP2 (13q22.3) / N4BP2L2 (13q13.1)
MYCBP2 (13q22.3) / NAT8L (4p16.3)MYCBP2 (13q22.3) / PCBP2 (12q13.13)MYCBP2 (13q22.3) / RNF219 (13q31.1)
HIPK2 7q34 / MYCBP2 13q22.3MYCBP2 13q22.3 / RNF219 13q31.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)MYCBP2   23386
Cards
Entrez_Gene (NCBI)MYCBP2    MYC binding protein 2
AliasesMyc-bp2; PAM; PHR1; Phr
GeneCards (Weizmann)MYCBP2
Ensembl hg19 (Hinxton)ENSG00000005810 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000005810 [Gene_View]  ENSG00000005810 [Sequence]  chr13:77044657-77327094 [Contig_View]  MYCBP2 [Vega]
ICGC DataPortalENSG00000005810
TCGA cBioPortalMYCBP2
AceView (NCBI)MYCBP2
Genatlas (Paris)MYCBP2
SOURCE (Princeton)MYCBP2
Genetics Home Reference (NIH)MYCBP2
Genomic and cartography
GoldenPath hg38 (UCSC)MYCBP2  -     chr13:77044657-77327094 -  13q22.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MYCBP2  -     13q22.3   [Description]    (hg19-Feb_2009)
GoldenPathMYCBP2 - 13q22.3 [CytoView hg19]  MYCBP2 - 13q22.3 [CytoView hg38]
ImmunoBaseENSG00000005810
Genome Data Viewer NCBIMYCBP2 [Mapview hg19]  
OMIM610392   
Gene and transcription
Genbank (Entrez)AA236471 AB020723 AF075587 AF083244 AK000968
RefSeq transcript (Entrez)NM_015057
Consensus coding sequences : CCDS (NCBI)MYCBP2
Gene ExpressionMYCBP2 [ NCBI-GEO ]   MYCBP2 [ EBI - ARRAY_EXPRESS ]   MYCBP2 [ SEEK ]   MYCBP2 [ MEM ]
Gene Expression Viewer (FireBrowse)MYCBP2 [ Firebrowse - Broad ]
GenevisibleExpression of MYCBP2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)23077
GTEX Portal (Tissue expression)MYCBP2
Human Protein AtlasENSG00000005810-MYCBP2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO75592   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO75592  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO75592
PhosPhoSitePlusO75592
Domaine pattern : Prosite (Expaxy)DOC (PS51284)    FILAMIN_REPEAT (PS50194)    RCC1_2 (PS00626)    RCC1_3 (PS50012)    ZF_RING_2 (PS50089)   
Domains : Interpro (EBI)APC_su10/DOC_dom    Filamin/ABP280_repeat-like    Galactose-bd-like_sf    Ig_E-set    PHR    PHR_sf    RCC1/BLIP-II    Reg_chr_condens    SH3-like_bac-type    Znf_RING    Znf_RING/FYVE/PHD   
Domain families : Pfam (Sanger)ANAPC10 (PF03256)    PHR (PF08005)    RCC1 (PF00415)    SH3_3 (PF08239)    zf-RING_2 (PF13639)   
Domain families : Pfam (NCBI)pfam03256    pfam08005    pfam00415    pfam08239    pfam13639   
Domain families : Smart (EMBL)APC10 (SM01337)  RING (SM00184)  
Conserved Domain (NCBI)MYCBP2
PDB (RSDB)5O6C    6T7F   
PDB Europe5O6C    6T7F   
PDB (PDBSum)5O6C    6T7F   
PDB (IMB)5O6C    6T7F   
Structural Biology KnowledgeBase5O6C    6T7F   
SCOP (Structural Classification of Proteins)5O6C    6T7F   
CATH (Classification of proteins structures)5O6C    6T7F   
SuperfamilyO75592
AlphaFold pdb e-kbO75592   
Human Protein Atlas [tissue]ENSG00000005810-MYCBP2 [tissue]
HPRD10104
Protein Interaction databases
DIP (DOE-UCLA)O75592
IntAct (EBI)O75592
BioGRIDMYCBP2
STRING (EMBL)MYCBP2
ZODIACMYCBP2
Ontologies - Pathways
QuickGOO75592
Ontology : AmiGOguanyl-nucleotide exchange factor activity  protein binding  nucleus  nucleus  nucleoplasm  cytoplasm  zinc ion binding  microtubule cytoskeleton  membrane  protein ubiquitination  protein ubiquitination  protein ubiquitination  branchiomotor neuron axon guidance  central nervous system projection neuron axonogenesis  axon  small GTPase binding  positive regulation of protein ubiquitination  regulation of protein localization  circadian regulation of gene expression  negative regulation of protein catabolic process  identical protein binding  intracellular membrane-bounded organelle  regulation of catalytic activity  neuromuscular process  regulation of cytoskeleton organization  ubiquitin protein ligase activity  regulation of axon guidance  
Ontology : EGO-EBIguanyl-nucleotide exchange factor activity  protein binding  nucleus  nucleus  nucleoplasm  cytoplasm  zinc ion binding  microtubule cytoskeleton  membrane  protein ubiquitination  protein ubiquitination  protein ubiquitination  branchiomotor neuron axon guidance  central nervous system projection neuron axonogenesis  axon  small GTPase binding  positive regulation of protein ubiquitination  regulation of protein localization  circadian regulation of gene expression  negative regulation of protein catabolic process  identical protein binding  intracellular membrane-bounded organelle  regulation of catalytic activity  neuromuscular process  regulation of cytoskeleton organization  ubiquitin protein ligase activity  regulation of axon guidance  
NDEx NetworkMYCBP2
Atlas of Cancer Signalling NetworkMYCBP2
Wikipedia pathwaysMYCBP2
Orthology - Evolution
OrthoDB23077
GeneTree (enSembl)ENSG00000005810
Phylogenetic Trees/Animal Genes : TreeFamMYCBP2
Homologs : HomoloGeneMYCBP2
Homology/Alignments : Family Browser (UCSC)MYCBP2
Gene fusions - Rearrangements
Fusion : MitelmanHIPK2/MYCBP2 [7q34/13q22.3]  
Fusion : MitelmanMYCBP2/RNF219 [13q22.3/13q31.1]  
Fusion : QuiverMYCBP2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMYCBP2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MYCBP2
dbVarMYCBP2
ClinVarMYCBP2
MonarchMYCBP2
1000_GenomesMYCBP2 
Exome Variant ServerMYCBP2
GNOMAD BrowserENSG00000005810
Varsome BrowserMYCBP2
ACMGMYCBP2 variants
VarityO75592
Genomic Variants (DGV)MYCBP2 [DGVbeta]
DECIPHERMYCBP2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMYCBP2 
Mutations
ICGC Data PortalMYCBP2 
TCGA Data PortalMYCBP2 
Broad Tumor PortalMYCBP2
OASIS PortalMYCBP2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMYCBP2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DMYCBP2
Mutations and Diseases : HGMDMYCBP2
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaMYCBP2
DgiDB (Drug Gene Interaction Database)MYCBP2
DoCM (Curated mutations)MYCBP2
CIViC (Clinical Interpretations of Variants in Cancer)MYCBP2
Cancer3DMYCBP2
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM610392   
Orphanet
DisGeNETMYCBP2
MedgenMYCBP2
Genetic Testing Registry MYCBP2
NextProtO75592 [Medical]
GENETestsMYCBP2
Target ValidationMYCBP2
Huge Navigator MYCBP2 [HugePedia]
ClinGenMYCBP2
Clinical trials, drugs, therapy
MyCancerGenomeMYCBP2
Protein Interactions : CTDMYCBP2
Pharm GKB GenePA134871126
PharosO75592
Clinical trialMYCBP2
Miscellaneous
canSAR (ICR)MYCBP2
HarmonizomeMYCBP2
DataMed IndexMYCBP2
Probes
Litterature
PubMed102 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXMYCBP2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:21:42 CEST 2021

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