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MYCL (MYCL proto-oncogene, bHLH transcription factor)

Identity

Alias_namesMYCL1
v-myc avian myelocytomatosis viral oncogene homolog 1
Alias_symbol (synonym)LMYC
bHLHe38
Other aliasL-Myc
HGNC (Hugo) MYCL
LocusID (NCBI) 4610
Atlas_Id 170
Location 1p34.2  [Link to chromosome band 1p34]
Location_base_pair Starts at 39895424 and ends at 39902015 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
MYCL (1p34.2) / MGP (12p12.3)PPIE (1p34.2) / MYCL (1p34.2)RLF (1p34.2) / MYCL (1p34.2)
SMAP2 (1p34.2) / MYCL (1p34.2)TRIT1 (1p34.2) / MYCL (1p34.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(8;14)(q24;q32) IGH/MYC::t(2;8)(p12;q24) IGK/MYC::t(8;22)(q24;q11) IGL/MYC


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 3 ]
  Head and Neck: Odontogenic tumor: Ameloblastoma
Lung: small cell cancer
Lung: Translocations in Small Cell Carcinoma


External links

Nomenclature
HGNC (Hugo)MYCL   7555
Cards
Entrez_Gene (NCBI)MYCL  4610  MYCL proto-oncogene, bHLH transcription factor
AliasesL-Myc; LMYC; MYCL1; bHLHe38
GeneCards (Weizmann)MYCL
Ensembl hg19 (Hinxton)ENSG00000116990 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000116990 [Gene_View]  chr1:39895424-39902015 [Contig_View]  MYCL [Vega]
ICGC DataPortalENSG00000116990
TCGA cBioPortalMYCL
AceView (NCBI)MYCL
Genatlas (Paris)MYCL
WikiGenes4610
SOURCE (Princeton)MYCL
Genetics Home Reference (NIH)MYCL
Genomic and cartography
GoldenPath hg38 (UCSC)MYCL  -   :&nbóp;"nbsp;chr1:39895424-39902015 -  1p34.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MYCL  -     1p34.2   [Description]    (hg19-Feb_2009)
EnsemblMYCL - 1p34.2 [CytoView hg19]  MYCL - 1p34.2 [CytoView hg38]
Mapping of homologs : NCBIMYCL [Mapview hg19]  MYCL [Mapview hg38]
OMIM164850   
Gene and transcription
Genbank (Entrez)AI144219 AK296078 AK296838 BC011864 BC030694
RefSeq transcript (Entrez)NM_001033081 NM_001033082 NM_005376
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)MYCL
Cluster EST : UnigeneHs.437922 [ NCBI ]
CGAP (NCI)Hs.437922
Alternative Splicing GalleryENSG00000116990
Gene ExpressionMYCL [ NCBI-GEO ]   MYCL [ EBI - ARRAY_EXPRESS ]   MYCL [ SEEK ]   MYCL [ MEM ]
Gene Expression Viewer (FireBrowse)MYCL [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4610
GTEX Portal (Tissue expression)MYCL
Protein : pattern, domain, 3D structure
UniProt/SwissProtP12524   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP12524  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP12524
Splice isoforms : SwissVarP12524
PhosPhoSitePlusP12524
Domaine pattern : Prosite (Expaxy)BHLH (PS50888)   
Domains : Interpro (EBI)bHLH_dom    Tscrpt_reg_Myc    Tscrpt_reg_Myc_N   
Domain families : Pfam (Sanger)HLH (PF00010)    Myc_N (PF01056)   
Domain families : Pfam (NCBI)pfam00010    pfam01056   
Domain families : Smart (EMBL)HLH (SM00353)  
Conserved Domain (NCBI)MYCL
DMDM Disease mutations4610
Blocks (Seattle)MYCL
SuperfamilyP12524
Human Protein AtlasENSG00000116990
Peptide AtlasP12524
HPRD01279
IPIIPI00796676   IPI00513857   IPI00643210   IPI00985328   
Protein Interaction databases
DIP (DOE-UCLA)P12524
IntAct (EBI)P12524
FunCoupENSG00000116990
BioGRIDMYCL
STRING (EMBL)MYCL
ZODIACMYCL
Ontologies - Pathways
QuickGOP12524
Ontology : AmiGODNA binding  DNA binding  transcription factor activity, sequence-specific DNA binding  nucleus  regulation of transcription, DNA-templated  regulation of auditory receptor cell differentiation  protein dimerization activity  
Ontology : EGO-EBIDNA binding  DNA binding  transcription factor activity, sequence-specific DNA binding  nucleus  regulation of transcription, DNA-templated  regulation of auditory receptor cell differentiation  protein dimerization activity  
NDEx NetworkMYCL
Atlas of Cancer Signalling NetworkMYCL
Wikipedia pathwaysMYCL
Orthology - Evolution
OrthoDB4610
GeneTree (enSembl)ENSG00000116990
Phylogenetic Trees/Animal Genes : TreeFamMYCL
HOVERGENP12524
HOGENOMP12524
Homologs : HomoloGeneMYCL
Homology/Alignments : Family Browser (UCSC)MYCL
Gene fusions - Rearrangements
Fusion : MitelmanRLF/MYCL [1p34.2/1p34.2]  [inv(1)(p34p34)]  [t(1;1)(p34;p34)]  
Fusion : MitelmanSMAP2/MYCL [1p34.2/1p34.2]  [t(1;1)(p34;p34)]  
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMYCL [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MYCL
dbVarMYCL
ClinVarMYCL
1000_GenomesMYCL 
Exome Variant ServerMYCL
ExAC (Exome Aggregation Consortium)MYCL (select the gene name)
Genetic variants : HAPMAP4610
Genomic Variants (DGV)MYCL [DGVbeta]
DECIPHERMYCL [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMYCL 
Mutations
ICGC Data PortalMYCL 
TCGA Data PortalMYCL 
Broad Tumor PortalMYCL
OASIS PortalMYCL [ Somatic mutations - Copy number]
Cancer Gene: CensusMYCL 
Somatic Mutations in Cancer : COSMICMYCL  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDMYCL
BioMutasearch MYCL
DgiDB (Drug Gene Interaction Database)MYCL
DoCM (Curated mutations)MYCL (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MYCL (select a term)
intoGenMYCL
Cancer3DMYCL(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM164850   
Orphanet
MedgenMYCL
Genetic Testing Registry MYCL
NextProtP12524 [Medical]
TSGene4610
GENETestsMYCL
Target ValidationMYCL
Huge Navigator MYCL [HugePedia]
snp3D : Map Gene to Disease4610
BioCentury BCIQMYCL
ClinGenMYCL
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD4610
Chemical/Pharm GKB GenePA31355
Drug Sensitivity MYCL
Clinical trialMYCL
Miscellaneous
canSAR (ICR)MYCL (select the gene name)
Probes
Litterature
PubMed38 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMYCL
EVEXMYCL
GoPubMedMYCL
iHOPMYCL
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 25 19:20:59 CEST 2017

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