MYD88 (myeloid differentiation primary response gene (88))

Identity

Other names	-
HGNC	MYD88
Location	3p22
Location_base_pair	Starts at 38155009 and ends at 38159516 bp from pter ( according to hg18-March_2006).
Note	Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

External links

	Nomenclature
HGNC	MYD88   7562
Entrez_Gene	MYD88  4615  myeloid differentiation primary response gene (88)
	Cards
GeneCards	MYD88
Ensembl	MYD88 [Search_View]   ENSG00000172936 [Gene_View]
Genatlas	MYD88
GeneLynx	MYD88
eGenome	MYD88
euGene	4615
	Genomic and cartography
GoldenPath	MYD88  -  3p22   chr3:38155009-38159516 +  3p22.2   [Description]    (hg18-March_2006)
Ensembl	MYD88 - 3p22.2 [CytoView]
NCBI	Mapview
OMIM	Disease map [OMIM]
HomoloGene	MYD88
	Gene and transcription
Genbank	AB446470 [ ENTREZ ]
Genbank	AK097983 [ ENTREZ ]
Genbank	AK124685 [ ENTREZ ]
Genbank	AL832906 [ ENTREZ ]
Genbank	BC013589 [ ENTREZ ]
RefSeq	NM_002468 [ SRS ]    NM_002468 [ ENTREZ ]
RefSeq	AC_000046 [ SRS ]    AC_000046 [ ENTREZ ]
RefSeq	AC_000135 [ SRS ]    AC_000135 [ ENTREZ ]
RefSeq	NC_000003 [ SRS ]    NC_000003 [ ENTREZ ]
RefSeq	NT_022517 [ SRS ]    NT_022517 [ ENTREZ ]
RefSeq	NW_001838877 [ SRS ]    NW_001838877 [ ENTREZ ]
RefSeq	NW_921651 [ SRS ]    NW_921651 [ ENTREZ ]
AceView	MYD88 AceView - NCBI
Unigene	Hs.82116 [ SRS ]    Hs.82116 [ NCBI ]     HS82116 [ spliceNest ]
Fast-db	4193 (alternative variants)
	Protein : pattern, domain, 3D structure
SwissProt	Q53XS7 [ SRS]    Q53XS7 [ EXPASY ]     Q53XS7 [ INTERPRO ]     Q53XS7 [ UNIPROT ]
Prosite	PS50017 DEATH_DOMAIN [ SRS ]    PS50017 DEATH_DOMAIN [ Expasy ]
Prosite	PS50104 TIR [ SRS ]    PS50104 TIR [ Expasy ]
Interpro	IPR000488 Death [ SRS ]    IPR000488 Death [ EBI ]
Interpro	IPR011029 DEATH_like [ SRS ]    IPR011029 DEATH_like [ EBI ]
Interpro	IPR004075 IL1_rcpt_1 [ SRS ]    IPR004075 IL1_rcpt_1 [ EBI ]
Interpro	IPR017281 Myelin_different_resp_MyD88 [ SRS ]    IPR017281 Myelin_different_resp_MyD88 [ EBI ]
Interpro	IPR000157 TIR [ SRS ]    IPR000157 TIR [ EBI ]
CluSTr	Q53XS7
Pfam	PF00531 Death [ SRS ]    PF00531 Death [ Sanger ]    pfam00531 [ NCBI-CDD ]
Pfam	PF01582 TIR [ SRS ]    PF01582 TIR [ Sanger ]    pfam01582 [ NCBI-CDD ]
Smart	SM00005 DEATH [EMBL]
Smart	SM00255 TIR [EMBL]
Blocks	Q53XS7
HPRD	03703
	Protein Interaction databases
DIP	Q53XS7
IntAct	Q53XS7
	Polymorphism : SNP, mutations, diseases
OMIM	602170    [ map ]
GENECLINICS	602170
SNP	MYD88 [dbSNP-NCBI]
SNP	NM_002468 [SNP-NCI]
SNP	MYD88 [GeneSNPs - Utah]  MYD88] [HGBASE - SRS]
HAPMAP	MYD88 [HAPMAP]
HGMD	MYD88
	General knowledge
Family Browser	MYD88 [UCSC Family Browser]
SOURCE	NM_002468
SMD	Hs.82116
SAGE	Hs.82116
GO	response to molecule of fungal origin [Amigo]  response to molecule of fungal origin
GO	MyD88-dependent toll-like receptor signaling pathway [Amigo]  MyD88-dependent toll-like receptor signaling pathway
GO	transmembrane receptor activity [Amigo]  transmembrane receptor activity
GO	Toll binding [Amigo]  Toll binding
GO	death receptor binding [Amigo]  death receptor binding
GO	protein binding [Amigo]  protein binding
GO	cytoplasm [Amigo]  cytoplasm
GO	inflammatory response [Amigo]  inflammatory response
GO	Toll signaling pathway [Amigo]  Toll signaling pathway
GO	response to virus [Amigo]  response to virus
GO	immunoglobulin mediated immune response [Amigo]  immunoglobulin mediated immune response
GO	cytokine and chemokine mediated signaling pathway [Amigo]  cytokine and chemokine mediated signaling pathway
GO	intrinsic to membrane [Amigo]  intrinsic to membrane
GO	lipopolysaccharide-mediated signaling pathway [Amigo]  lipopolysaccharide-mediated signaling pathway
GO	response to lipopolysaccharide [Amigo]  response to lipopolysaccharide
GO	positive regulation of tumor necrosis factor production [Amigo]  positive regulation of tumor necrosis factor production
GO	positive regulation of I-kappaB kinase/NF-kappaB cascade [Amigo]  positive regulation of I-kappaB kinase/NF-kappaB cascade
GO	positive regulation of chemokine biosynthetic process [Amigo]  positive regulation of chemokine biosynthetic process
GO	innate immune response [Amigo]  innate immune response
GO	type I interferon biosynthetic process [Amigo]  type I interferon biosynthetic process
GO	positive regulation of transcription from RNA polymerase II promoter [Amigo]  positive regulation of transcription from RNA polymerase II promoter
GO	positive regulation of JNK cascade [Amigo]  positive regulation of JNK cascade
GO	positive regulation of smooth muscle cell proliferation [Amigo]  positive regulation of smooth muscle cell proliferation
GO	positive regulation of NF-kappaB transcription factor activity [Amigo]  positive regulation of NF-kappaB transcription factor activity
BIOCARTA	Inactivation of Gsk3 by AKT causes accumulation of b-catenin in Alveolar Macrophages    [Genes]
BIOCARTA	Signal transduction through IL1R    [Genes]
BIOCARTA	NF-kB Signaling Pathway    [Genes]
BIOCARTA	NFkB activation by Nontypeable Hemophilus influenzae    [Genes]
BIOCARTA	Toll-Like Receptor Pathway    [Genes]
KEGG	Apoptosis
KEGG	Toll-like receptor signaling pathway
PubGene	MYD88
TreeFam	MYD88
CTD	4615 [Comparative ToxicoGenomics Database]
	Other databases
	Probes
Probe	MYD88 Related clones (RZPD - Berlin)
	PubMed
PubMed	68 Pubmed reference(s) in Entrez

Genes in title	automatic search in PubMed
REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

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Contributor(s)

Written	09-2002	Dessen P, Le Minor S
Updated	03-2008	Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Sat Oct 18 14:51:38 2008