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MYD88 (myeloid differentiation primary response 88)

Identity

Other namesMYD88D
HGNC (Hugo) MYD88
LocusID (NCBI) 4615
Atlas_Id 41476
Location 3p22.2
Location_base_pair Starts at 38179969 and ends at 38184512 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
MYD88 (3p22.2) / ARHGEF10L (1p36.13)MYD88 (3p22.2) / INO80B (2p13.1)MYD88 (3p22.2) / MYLK (3q21.1)
NEURL1B (5q35.1) / MYD88 (3p22.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)MYD88   7562
Cards
Entrez_Gene (NCBI)MYD88  4615  myeloid differentiation primary response 88
GeneCards (Weizmann)MYD88
Ensembl hg19 (Hinxton)ENSG00000172936 [Gene_View]  chr3:38179969-38184512 [Contig_View]  MYD88 [Vega]
Ensembl hg38 (Hinxton)ENSG00000172936 [Gene_View]  chr3:38179969-38184512 [Contig_View]  MYD88 [Vega]
ICGC DataPortalENSG00000172936
TCGA cBioPortalMYD88
AceView (NCBI)MYD88
Genatlas (Paris)MYD88
WikiGenes4615
SOURCE (Princeton)MYD88
Genomic and cartography
GoldenPath hg19 (UCSC)MYD88  -     chr3:38179969-38184512 +  3p22.2   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)MYD88  -     3p22.2   [Description]    (hg38-Dec_2013)
EnsemblMYD88 - 3p22.2 [CytoView hg19]  MYD88 - 3p22.2 [CytoView hg38]
Mapping of homologs : NCBIMYD88 [Mapview hg19]  MYD88 [Mapview hg38]
OMIM153600   602170   612260   
Gene and transcription
Genbank (Entrez)AB446470 AK097983 AK124685 AK296570 AK296716
RefSeq transcript (Entrez)NM_001172566 NM_001172567 NM_001172568 NM_001172569 NM_002468
RefSeq genomic (Entrez)NC_000003 NC_018914 NG_016964 NT_022517 NW_004929309
Consensus coding sequences : CCDS (NCBI)MYD88
Cluster EST : UnigeneHs.82116 [ NCBI ]
CGAP (NCI)Hs.82116
Alternative Splicing GalleryENSG00000172936
Gene ExpressionMYD88 [ NCBI-GEO ]   MYD88 [ EBI - ARRAY_EXPRESS ]   MYD88 [ SEEK ]   MYD88 [ MEM ]
Gene Expression Viewer (FireBrowse)MYD88 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4615
GTEX Portal (Tissue expression)MYD88
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ99836 (Uniprot)
NextProtQ99836  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ99836
Splice isoforms : SwissVarQ99836 (Swissvar)
PhosPhoSitePlusQ99836
Domaine pattern : Prosite (Expaxy)DEATH_DOMAIN (PS50017)    TIR (PS50104)   
Domains : Interpro (EBI)DEATH-like_dom    Death_domain    Myelin_different_resp_MyD88    TIR_dom   
Domain families : Pfam (Sanger)Death (PF00531)    TIR (PF01582)   
Domain families : Pfam (NCBI)pfam00531    pfam01582   
Domain families : Smart (EMBL)DEATH (SM00005)  TIR (SM00255)  
DMDM Disease mutations4615
Blocks (Seattle)MYD88
PDB (SRS)2JS7    2Z5V    3MOP    4DOM    4EO7   
PDB (PDBSum)2JS7    2Z5V    3MOP    4DOM    4EO7   
PDB (IMB)2JS7    2Z5V    3MOP    4DOM    4EO7   
PDB (RSDB)2JS7    2Z5V    3MOP    4DOM    4EO7   
Structural Biology KnowledgeBase2JS7    2Z5V    3MOP    4DOM    4EO7   
SCOP (Structural Classification of Proteins)2JS7    2Z5V    3MOP    4DOM    4EO7   
CATH (Classification of proteins structures)2JS7    2Z5V    3MOP    4DOM    4EO7   
SuperfamilyQ99836
Human Protein AtlasENSG00000172936
Peptide AtlasQ99836
HPRD03703
IPIIPI00798074   IPI01013725   IPI00908714   IPI00924787   IPI00878858   IPI00910972   IPI00909842   IPI00925056   
Protein Interaction databases
DIP (DOE-UCLA)Q99836
IntAct (EBI)Q99836
FunCoupENSG00000172936
BioGRIDMYD88
STRING (EMBL)MYD88
ZODIACMYD88
Ontologies - Pathways
QuickGOQ99836
Ontology : AmiGOtoll-like receptor signaling pathway  MyD88-dependent toll-like receptor signaling pathway  death receptor binding  protein binding  cytosol  plasma membrane  inflammatory response  signal transduction  cell surface receptor signaling pathway  endosome membrane  positive regulation of type I interferon production  positive regulation of type I interferon production  positive regulation of interleukin-17 production  positive regulation of interleukin-23 production  positive regulation of interleukin-6 production  toll-like receptor 9 signaling pathway  identical protein binding  negative regulation of apoptotic process  positive regulation of I-kappaB kinase/NF-kappaB signaling  innate immune response  regulation of inflammatory response  defense response to Gram-positive bacterium  response to interleukin-1  3'-UTR-mediated mRNA stabilization  TIR domain binding  cellular response to mechanical stimulus  
Ontology : EGO-EBItoll-like receptor signaling pathway  MyD88-dependent toll-like receptor signaling pathway  death receptor binding  protein binding  cytosol  plasma membrane  inflammatory response  signal transduction  cell surface receptor signaling pathway  endosome membrane  positive regulation of type I interferon production  positive regulation of type I interferon production  positive regulation of interleukin-17 production  positive regulation of interleukin-23 production  positive regulation of interleukin-6 production  toll-like receptor 9 signaling pathway  identical protein binding  negative regulation of apoptotic process  positive regulation of I-kappaB kinase/NF-kappaB signaling  innate immune response  regulation of inflammatory response  defense response to Gram-positive bacterium  response to interleukin-1  3'-UTR-mediated mRNA stabilization  TIR domain binding  cellular response to mechanical stimulus  
Pathways : BIOCARTANFkB activation by Nontypeable Hemophilus influenzae [Genes]    Toll-Like Receptor Pathway [Genes]    Inactivation of Gsk3 by AKT causes accumulation of b-catenin in Alveolar Macrophages [Genes]    Signal transduction through IL1R [Genes]    NF-kB Signaling Pathway [Genes]   
Pathways : KEGGNF-kappa B signaling pathway    Apoptosis    Toll-like receptor signaling pathway    Salmonella infection    Pertussis    Legionellosis    Leishmaniasis    Chagas disease (American trypanosomiasis)    African trypanosomiasis    Malaria    Toxoplasmosis    Tuberculosis    Hepatitis B    Measles    Influenza A    Herpes simplex infection   
NDEx Network
Atlas of Cancer Signalling NetworkMYD88
Wikipedia pathwaysMYD88
Orthology - Evolution
OrthoDB4615
GeneTree (enSembl)ENSG00000172936
Phylogenetic Trees/Animal Genes : TreeFamMYD88
Homologs : HomoloGeneMYD88
Homology/Alignments : Family Browser (UCSC)MYD88
Gene fusions - Rearrangements
Polymorphisms : SNP, variants
NCBI Variation ViewerMYD88 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MYD88
dbVarMYD88
ClinVarMYD88
1000_GenomesMYD88 
Exome Variant ServerMYD88
ExAC (Exome Aggregation Consortium)MYD88 (select the gene name)
Genetic variants : HAPMAP4615
Genomic Variants (DGV)MYD88 [DGVbeta]
Mutations
ICGC Data PortalMYD88 
TCGA Data PortalMYD88 
Broad Tumor PortalMYD88
OASIS PortalMYD88 [ Somatic mutations - Copy number]
Cancer Gene: CensusMYD88 
Somatic Mutations in Cancer : COSMICMYD88 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)**PUBLIC** CCHMC Molecular Genetics Laboratory Mutation Database
LOVD (Leiden Open Variation Database)Pharmacogenomics of Infectious Diseases (PGx_IfD )
BioMutasearch MYD88
DgiDB (Drug Gene Interaction Database)MYD88
DoCM (Curated mutations)MYD88 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MYD88 (select a term)
intoGenMYD88
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)3:38179969-38184512  ENSG00000172936
CONAN: Copy Number AnalysisMYD88 
Mutations and Diseases : HGMDMYD88
OMIM153600    602170    612260   
MedgenMYD88
Genetic Testing Registry MYD88
NextProtQ99836 [Medical]
TSGene4615
GENETestsMYD88
Huge Navigator MYD88 [HugePedia]
snp3D : Map Gene to Disease4615
BioCentury BCIQMYD88
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD4615
Chemical/Pharm GKB GenePA31361
Clinical trialMYD88
Miscellaneous
canSAR (ICR)MYD88 (select the gene name)
Probes
Litterature
PubMed330 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMYD88
EVEXMYD88
GoPubMedMYD88
iHOPMYD88
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Sun May 8 18:57:11 CEST 2016

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