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MYD88 (myeloid differentiation primary response 88)

Identity

Other namesMYD88D
HGNC (Hugo) MYD88
LocusID (NCBI) 4615
Location 3p22.2
Location_base_pair Starts at 38179969 and ends at 38184512 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)MYD88   7562
Entrez_Gene (NCBI)MYD88  4615  myeloid differentiation primary response 88
Cards
GeneCards (Weizmann)MYD88
Ensembl (Hinxton)ENSG00000172936 [Gene_View]  chr3:38179969-38184512 [Contig_View]  MYD88 [Vega]
AceView (NCBI)MYD88
Genatlas (Paris)MYD88
SOURCE (Stanford)NM_001172566 NM_001172567 NM_001172568 NM_001172569 NM_002468
Genomic and cartography
GoldenPath (UCSC)MYD88  -  3p22.2   chr3:38179969-38184512 +  3p22.2   [Description]    (hg19-Feb_2009)
EnsemblMYD88 - 3p22.2 [CytoView]
Mapping of homologs : NCBIMYD88 [Mapview]
OMIM153600   602170   612260   
Gene and transcription
Genbank (Entrez)AB446470 AK097983 AK124685 AK296570 AK296716
RefSeq transcript (SRS)NM_001172566 NM_001172567 NM_001172568 NM_001172569 NM_002468
RefSeq transcript (Entrez)NM_001172566 NM_001172567 NM_001172568 NM_001172569 NM_002468
RefSeq genomic (SRS)AC_000135 NC_000003 NC_018914 NG_016964 NT_022517 NW_001838877 NW_004078011
RefSeq genomic (Entrez)AC_000135 NC_000003 NC_018914 NG_016964 NT_022517 NW_001838877 NW_004078011
Consensus coding sequences : CCDS (NCBI)MYD88
Cluster EST : UnigeneHs.82116 [ SRS ] Hs.82116 [ NCBI ]
CGAP (NCI)Hs.82116
Alternative Splicing : Fast-db (Paris)GSHG0020700
Alternative Splicing GalleryENSG00000172936
Gene ExpressionMYD88 [ NCBI-GEO ]   MYD88 [ EBI - ARRAY_EXPRESS ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ99836 (SRS) Q99836 (Uniprot)
NextProtQ99836
With graphics : InterProQ99836
Splice isoforms : SwissVarQ99836(Swissvar)
Domaine pattern : Prosite (SRS)DEATH_DOMAIN (PS50017)    TIR (PS50104)   
Domaine pattern : Prosite (Expaxy)DEATH_DOMAIN (PS50017)    TIR (PS50104)   
Domains : Interpro (SRS)Death    DEATH-like    Myelin_different_resp_MyD88    TIR_dom   
Domains : Interpro (EBI)Death    DEATH-like    Myelin_different_resp_MyD88    TIR_dom   
Related proteins : CluSTrQ99836
Domain families : Pfam (SRS)Death (PF00531)    TIR (PF01582)   
Domain families : Pfam (Sanger)Death (PF00531)    TIR (PF01582)   
Domain families : Pfam (NCBI)pfam00531    pfam01582   
Domain families : Smart (EMBL)DEATH (SM00005)  TIR (SM00255)  
DMDM4615
Blocks (Seattle)Q99836
PDB (SRS)2JS7    2Z5V    3MOP   
PDB (PDBSum)2JS7    2Z5V    3MOP   
PDB (IMB)2JS7    2Z5V    3MOP   
PDB (RSDB)2JS7    2Z5V    3MOP   
Human Protein AtlasENSG00000172936
HPRD03703
IPIIPI00798074   IPI01013725   IPI00908714   IPI00924787   IPI00878858   IPI00910972   IPI00909842   IPI00925056   
Protein Interaction databases
DIP (DOE-UCLA)Q99836
IntAct (EBI)Q99836
FunCoupENSG00000172936
REACTOMEMYD88
Protein Interaction Database4615
BioGRIDMYD88
InParanoidQ99836
Interologous Interaction database Q99836
IntegromeDBMYD88
Polymorphism : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)MYD88
SNP (GeneSNP Utah)MYD88
SNP : HGBaseMYD88
Genetic variants : HAPMAPMYD88
Cancer Gene: CensusMYD88 
Somatic Mutations in Cancer : COSMICMYD88 
CONAN: Copy Number AnalysisMYD88 
Mutations and Diseases : HGMDMYD88
OMIM153600    602170    612260   
GENETests153600    602170    612260   
Disease Genetic AssociationMYD88
Huge Navigator MYD88 [HugePedia]  MYD88 [HugeCancerGEM]
Genomic VariantsMYD88  MYD88 [DGVbeta]
snp3D : Map Gene to Disease4615
General knowledge
Homologs : HomoloGeneMYD88
Homology/Alignments : Family Browser (UCSC)MYD88
Phylogenetic Trees/Animal Genes : TreeFamMYD88
Chemical/Protein Interactions : CTD4615
Chemical/Pharm GKB GenePA31361
Clinical trialMYD88
Cancer Resource (Charite)ENSG00000172936
Ontology : AmiGOtoll-like receptor signaling pathway  response to molecule of fungal origin  MyD88-dependent toll-like receptor signaling pathway  Toll binding  death receptor binding  protein binding  cytosol  plasma membrane  inflammatory response  signal transduction  cell surface receptor signaling pathway  JNK cascade  Toll signaling pathway  response to virus  endosome membrane  immunoglobulin mediated immune response  cytokine-mediated signaling pathway  lipopolysaccharide-mediated signaling pathway  response to peptidoglycan  positive regulation of interleukin-17 production  positive regulation of interleukin-23 production  positive regulation of interleukin-6 production  positive regulation of tumor necrosis factor production  toll-like receptor 1 signaling pathway  toll-like receptor 2 signaling pathway  toll-like receptor 4 signaling pathway  identical protein binding  positive regulation of I-kappaB kinase/NF-kappaB cascade  negative regulation of growth of symbiont in host  positive regulation of chemokine biosynthetic process  innate immune response  type I interferon biosynthetic process  positive regulation of transcription from RNA polymerase II promoter  positive regulation of JNK cascade  nerve growth factor receptor signaling pathway  positive regulation of smooth muscle cell proliferation  positive regulation of lymphocyte proliferation  regulation of inflammatory response  defense response to Gram-positive bacterium  positive regulation of NF-kappaB transcription factor activity  response to interleukin-1  3'-UTR-mediated mRNA stabilization  TIR domain binding  cellular response to mechanical stimulus  
Ontology : EGO-EBItoll-like receptor signaling pathway  response to molecule of fungal origin  MyD88-dependent toll-like receptor signaling pathway  Toll binding  death receptor binding  protein binding  cytosol  plasma membrane  inflammatory response  signal transduction  cell surface receptor signaling pathway  JNK cascade  Toll signaling pathway  response to virus  endosome membrane  immunoglobulin mediated immune response  cytokine-mediated signaling pathway  lipopolysaccharide-mediated signaling pathway  response to peptidoglycan  positive regulation of interleukin-17 production  positive regulation of interleukin-23 production  positive regulation of interleukin-6 production  positive regulation of tumor necrosis factor production  toll-like receptor 1 signaling pathway  toll-like receptor 2 signaling pathway  toll-like receptor 4 signaling pathway  identical protein binding  positive regulation of I-kappaB kinase/NF-kappaB cascade  negative regulation of growth of symbiont in host  positive regulation of chemokine biosynthetic process  innate immune response  type I interferon biosynthetic process  positive regulation of transcription from RNA polymerase II promoter  positive regulation of JNK cascade  nerve growth factor receptor signaling pathway  positive regulation of smooth muscle cell proliferation  positive regulation of lymphocyte proliferation  regulation of inflammatory response  defense response to Gram-positive bacterium  positive regulation of NF-kappaB transcription factor activity  response to interleukin-1  3'-UTR-mediated mRNA stabilization  TIR domain binding  cellular response to mechanical stimulus  
Pathways : BIOCARTANFkB activation by Nontypeable Hemophilus influenzae [Genes]    Toll-Like Receptor Pathway [Genes]    Inactivation of Gsk3 by AKT causes accumulation of b-catenin in Alveolar Macrophages [Genes]    Signal transduction through IL1R [Genes]    NF-kB Signaling Pathway [Genes]   
Pathways : KEGGToll-like receptor signaling pathwayApoptosis
Other databases
Probes
Litterature
PubMed215 Pubmed reference(s) in Entrez
PubGeneMYD88
iHOPMYD88
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated01-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed May 1 12:26:14 CEST 2013
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