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MYH10 (myosin, heavy chain 10, non-muscle)

Identity

Alias_namesmyosin
Alias_symbol (synonym)NMMHCB
Other aliasNMMHC-IIB
HGNC (Hugo) MYH10
LocusID (NCBI) 4628
Atlas_Id 41478
Location 17p13.1  [Link to chromosome band 17p13]
Location_base_pair Starts at 8377523 and ends at 8534079 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
AURKB (17p13.1) / MYH10 (17p13.1)GAS8 (16q24.3) / MYH10 (17p13.1)KIF1C (17p13.2) / MYH10 (17p13.1)
LGI4 (19q13.12) / MYH10 (17p13.1)MYH10 (17p13.1) / ARHGEF10L (1p36.13)MYH10 (17p13.1) / GAS8 (16q24.3)
USP22 (17p11.2) / MYH10 (17p13.1)AURKB 17p13.1 / MYH10 17p13.1USP22 17p11.2 / MYH10 17p13.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)MYH10   7568
Cards
Entrez_Gene (NCBI)MYH10  4628  myosin, heavy chain 10, non-muscle
AliasesNMMHC-IIB; NMMHCB
GeneCards (Weizmann)MYH10
Ensembl hg19 (Hinxton)ENSG00000133026 [Gene_View]  chr17:8377523-8534079 [Contig_View]  MYH10 [Vega]
Ensembl hg38 (Hinxton)ENSG00000133026 [Gene_View]  chr17:8377523-8534079 [Contig_View]  MYH10 [Vega]
ICGC DataPortalENSG00000133026
TCGA cBioPortalMYH10
AceView (NCBI)MYH10
Genatlas (Paris)MYH10
WikiGenes4628
SOURCE (Princeton)MYH10
Genetics Home Reference (NIH)MYH10
Genomic and cartography
GoldenPath hg19 (UCSC)MYH10  -     chr17:8377523-8534079 -  17p13.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)MYH10  -     17p13.1   [Description]    (hg38-Dec_2013)
EnsemblMYH10 - 17p13.1 [CytoView hg19]  MYH10 - 17p13.1 [CytoView hg38]
Mapping of homologs : NCBIMYH10 [Mapview hg19]  MYH10 [Mapview hg38]
OMIM160776   
Gene and transcription
Genbank (Entrez)AB210026 AB621820 AF086505 AK026977 BC000280
RefSeq transcript (Entrez)NM_001256012 NM_001256095 NM_005964
RefSeq genomic (Entrez)NC_000017 NC_018928 NG_042305 NT_010718 NW_004929405
Consensus coding sequences : CCDS (NCBI)MYH10
Cluster EST : UnigeneHs.16355 [ NCBI ]
CGAP (NCI)Hs.16355
Alternative Splicing GalleryENSG00000133026
Gene ExpressionMYH10 [ NCBI-GEO ]   MYH10 [ EBI - ARRAY_EXPRESS ]   MYH10 [ SEEK ]   MYH10 [ MEM ]
Gene Expression Viewer (FireBrowse)MYH10 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4628
GTEX Portal (Tissue expression)MYH10
Protein : pattern, domain, 3D structure
UniProt/SwissProtP35580   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP35580  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP35580
Splice isoforms : SwissVarP35580
PhosPhoSitePlusP35580
Domaine pattern : Prosite (Expaxy)IQ (PS50096)    MYOSIN_MOTOR (PS51456)   
Domains : Interpro (EBI)IQ_motif_EF-hand-BS    Myosin-like_IQ_dom    Myosin_head_motor_dom    Myosin_N    Myosin_S1_N    Myosin_tail    P-loop_NTPase   
Domain families : Pfam (Sanger)IQ (PF00612)    Myosin_head (PF00063)    Myosin_N (PF02736)    Myosin_tail_1 (PF01576)   
Domain families : Pfam (NCBI)pfam00612    pfam00063    pfam02736    pfam01576   
Domain families : Smart (EMBL)IQ (SM00015)  MYSc (SM00242)  
Conserved Domain (NCBI)MYH10
DMDM Disease mutations4628
Blocks (Seattle)MYH10
PDB (SRS)4PD3   
PDB (PDBSum)4PD3   
PDB (IMB)4PD3   
PDB (RSDB)4PD3   
Structural Biology KnowledgeBase4PD3   
SCOP (Structural Classification of Proteins)4PD3   
CATH (Classification of proteins structures)4PD3   
SuperfamilyP35580
Human Protein AtlasENSG00000133026
Peptide AtlasP35580
HPRD01178
IPIIPI00397526   IPI00479307   IPI00790503   IPI00930228   IPI01025705   IPI00976415   
Protein Interaction databases
DIP (DOE-UCLA)P35580
IntAct (EBI)P35580
FunCoupENSG00000133026
BioGRIDMYH10
STRING (EMBL)MYH10
ZODIACMYH10
Ontologies - Pathways
QuickGOP35580
Ontology : AmiGOmicrofilament motor activity  mitotic cytokinesis  in utero embryonic development  stress fiber  neuron migration  plasma membrane repair  cardiac septum development  actin binding  protein binding  calmodulin binding  ATP binding  ATP binding  nucleus  cytoplasm  mitochondrion  spindle  cytosol  plasma membrane  brush border  cell cortex  exocytosis  substrate-dependent cell migration, cell extension  nuclear migration  cell adhesion  axon guidance  adult heart development  metabolic process  cell proliferation  regulation of cell shape  actin cytoskeleton  myosin complex  myosin II complex  fourth ventricle development  lateral ventricle development  third ventricle development  cerebellar Purkinje cell layer development  lamellipodium  actin filament-based movement  axon  growth cone  midbody  actin-dependent ATPase activity  actin-dependent ATPase activity  actomyosin structure organization  neuromuscular junction  cleavage furrow  aorta development  actomyosin  neuronal cell body  dendritic spine  ADP binding  neuromuscular process controlling balance  actin filament binding  actin filament binding  cardiac myofibril assembly  ventricular cardiac muscle cell development  retina development in camera-type eye  coronary vasculature development  extracellular exosome  myosin II filament  
Ontology : EGO-EBImicrofilament motor activity  mitotic cytokinesis  in utero embryonic development  stress fiber  neuron migration  plasma membrane repair  cardiac septum development  actin binding  protein binding  calmodulin binding  ATP binding  ATP binding  nucleus  cytoplasm  mitochondrion  spindle  cytosol  plasma membrane  brush border  cell cortex  exocytosis  substrate-dependent cell migration, cell extension  nuclear migration  cell adhesion  axon guidance  adult heart development  metabolic process  cell proliferation  regulation of cell shape  actin cytoskeleton  myosin complex  myosin II complex  fourth ventricle development  lateral ventricle development  third ventricle development  cerebellar Purkinje cell layer development  lamellipodium  actin filament-based movement  axon  growth cone  midbody  actin-dependent ATPase activity  actin-dependent ATPase activity  actomyosin structure organization  neuromuscular junction  cleavage furrow  aorta development  actomyosin  neuronal cell body  dendritic spine  ADP binding  neuromuscular process controlling balance  actin filament binding  actin filament binding  cardiac myofibril assembly  ventricular cardiac muscle cell development  retina development in camera-type eye  coronary vasculature development  extracellular exosome  myosin II filament  
Pathways : KEGGTight junction    Regulation of actin cytoskeleton    Salmonella infection   
NDEx NetworkMYH10
Atlas of Cancer Signalling NetworkMYH10
Wikipedia pathwaysMYH10
Orthology - Evolution
OrthoDB4628
GeneTree (enSembl)ENSG00000133026
Phylogenetic Trees/Animal Genes : TreeFamMYH10
HOVERGENP35580
HOGENOMP35580
Homologs : HomoloGeneMYH10
Homology/Alignments : Family Browser (UCSC)MYH10
Gene fusions - Rearrangements
Fusion : MitelmanAURKB/MYH10 [17p13.1/17p13.1]  [t(17;17)(p13;p13)]  
Fusion : MitelmanUSP22/MYH10 [17p11.2/17p13.1]  [t(17;17)(p11;p13)]  
Fusion: TCGAAURKB 17p13.1 MYH10 17p13.1 BRCA
Fusion: TCGAUSP22 17p11.2 MYH10 17p13.1 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMYH10 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MYH10
dbVarMYH10
ClinVarMYH10
1000_GenomesMYH10 
Exome Variant ServerMYH10
ExAC (Exome Aggregation Consortium)MYH10 (select the gene name)
Genetic variants : HAPMAP4628
Genomic Variants (DGV)MYH10 [DGVbeta]
DECIPHER (Syndromes)17:8377523-8534079  ENSG00000133026
CONAN: Copy Number AnalysisMYH10 
Mutations
ICGC Data PortalMYH10 
TCGA Data PortalMYH10 
Broad Tumor PortalMYH10
OASIS PortalMYH10 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMYH10  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDMYH10
intOGen PortalMYH10
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch MYH10
DgiDB (Drug Gene Interaction Database)MYH10
DoCM (Curated mutations)MYH10 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MYH10 (select a term)
intoGenMYH10
Cancer3DMYH10(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM160776   
Orphanet
MedgenMYH10
Genetic Testing Registry MYH10
NextProtP35580 [Medical]
TSGene4628
GENETestsMYH10
Huge Navigator MYH10 [HugePedia]
snp3D : Map Gene to Disease4628
BioCentury BCIQMYH10
ClinGenMYH10
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD4628
Chemical/Pharm GKB GenePA31366
Clinical trialMYH10
Miscellaneous
canSAR (ICR)MYH10 (select the gene name)
Probes
Litterature
PubMed98 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMYH10
EVEXMYH10
GoPubMedMYH10
iHOPMYH10
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Mar 30 15:11:24 CEST 2017

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