Atlas of Genetics and Cytogenetics in Oncology and Haematology

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MYH13 (myosin heavy chain 13)

Identity

Alias (NCBI)MyHC-IIL
MyHC-eo
HGNC (Hugo) MYH13
HGNC Alias symbMyHC-eo
HGNC Alias nameextraocular muscle myosin heavy chain
 extraocular myosin heavy chain
HGNC Previous namemyosin, heavy polypeptide 13, skeletal muscle
LocusID (NCBI) 8735
Atlas_Id 70607
Location 17p13.1  [Link to chromosome band 17p13]
Location_base_pair Starts at 10300866 and ends at 10373005 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
C4orf22 (4q21.21) / MYH13 (17p13.1)MYH13 (17p13.1) / RET (10q11.21)SMC5 (9q21.12) / MYH13 (17p13.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(10;17)(q11;p13) MYH13/RET

External links

Nomenclature
HGNC (Hugo)MYH13   7571
Cards
Entrez_Gene (NCBI)MYH13  8735  myosin heavy chain 13
AliasesMyHC-IIL; MyHC-eo
GeneCards (Weizmann)MYH13
Ensembl hg19 (Hinxton)ENSG00000006788 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000006788 [Gene_View]  ENSG00000006788 [Sequence]  chr17:10300866-10373005 [Contig_View]  MYH13 [Vega]
ICGC DataPortalENSG00000006788
TCGA cBioPortalMYH13
AceView (NCBI)MYH13
Genatlas (Paris)MYH13
WikiGenes8735
SOURCE (Princeton)MYH13
Genetics Home Reference (NIH)MYH13
Genomic and cartography
GoldenPath hg38 (UCSC)MYH13  -     chr17:10300866-10373005 -  17p13.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MYH13  -     17p13.1   [Description]    (hg19-Feb_2009)
GoldenPathMYH13 - 17p13.1 [CytoView hg19]  MYH13 - 17p13.1 [CytoView hg38]
ImmunoBaseENSG00000006788
genome Data Viewer NCBIMYH13 [Mapview hg19]  
OMIM603487   
Gene and transcription
Genbank (Entrez)AF111782 AK294316
RefSeq transcript (Entrez)NM_003802
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)MYH13
Alternative Splicing GalleryENSG00000006788
Gene ExpressionMYH13 [ NCBI-GEO ]   MYH13 [ EBI - ARRAY_EXPRESS ]   MYH13 [ SEEK ]   MYH13 [ MEM ]
Gene Expression Viewer (FireBrowse)MYH13 [ Firebrowse - Broad ]
GenevisibleExpression of MYH13 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8735
GTEX Portal (Tissue expression)MYH13
Human Protein AtlasENSG00000006788-MYH13 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UKX3   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9UKX3  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9UKX3
Splice isoforms : SwissVarQ9UKX3
PhosPhoSitePlusQ9UKX3
Domaine pattern : Prosite (Expaxy)IQ (PS50096)    MYOSIN_MOTOR (PS51456)    SH3_LIKE (PS51844)   
Domains : Interpro (EBI)IQ_motif_EF-hand-BS    Kinesin_motor_dom_sf    Myh13_MYSc    Myosin_head_motor_dom    Myosin_IQ_contain_sf    Myosin_N    Myosin_S1_N    Myosin_tail    P-loop_NTPase   
Domain families : Pfam (Sanger)Myosin_head (PF00063)    Myosin_N (PF02736)    Myosin_tail_1 (PF01576)   
Domain families : Pfam (NCBI)pfam00063    pfam02736    pfam01576   
Domain families : Smart (EMBL)MYSc (SM00242)  
Conserved Domain (NCBI)MYH13
DMDM Disease mutations8735
Blocks (Seattle)MYH13
SuperfamilyQ9UKX3
Human Protein Atlas [tissue]ENSG00000006788-MYH13 [tissue]
Peptide AtlasQ9UKX3
HPRD04599
IPIIPI00007858   IPI00910817   
Protein Interaction databases
DIP (DOE-UCLA)Q9UKX3
IntAct (EBI)Q9UKX3
FunCoupENSG00000006788
BioGRIDMYH13
STRING (EMBL)MYH13
ZODIACMYH13
Ontologies - Pathways
QuickGOQ9UKX3
Ontology : AmiGOmicrofilament motor activity  calmodulin binding  ATP binding  muscle myosin complex  muscle contraction  cellular response to starvation  myofibril  myosin filament  actin filament binding  extracellular exosome  
Ontology : EGO-EBImicrofilament motor activity  calmodulin binding  ATP binding  muscle myosin complex  muscle contraction  cellular response to starvation  myofibril  myosin filament  actin filament binding  extracellular exosome  
NDEx NetworkMYH13
Atlas of Cancer Signalling NetworkMYH13
Wikipedia pathwaysMYH13
Orthology - Evolution
OrthoDB8735
GeneTree (enSembl)ENSG00000006788
Phylogenetic Trees/Animal Genes : TreeFamMYH13
HOGENOMQ9UKX3
Homologs : HomoloGeneMYH13
Homology/Alignments : Family Browser (UCSC)MYH13
Gene fusions - Rearrangements
Fusion : QuiverMYH13
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMYH13 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MYH13
dbVarMYH13
ClinVarMYH13
1000_GenomesMYH13 
Exome Variant ServerMYH13
GNOMAD BrowserENSG00000006788
Varsome BrowserMYH13
Genetic variants : HAPMAP8735
Genomic Variants (DGV)MYH13 [DGVbeta]
DECIPHERMYH13 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMYH13 
Mutations
ICGC Data PortalMYH13 
TCGA Data PortalMYH13 
Broad Tumor PortalMYH13
OASIS PortalMYH13 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMYH13  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DMYH13
Mutations and Diseases : HGMDMYH13
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch MYH13
DgiDB (Drug Gene Interaction Database)MYH13
DoCM (Curated mutations)MYH13 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MYH13 (select a term)
intoGenMYH13
Cancer3DMYH13(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603487   
Orphanet
DisGeNETMYH13
MedgenMYH13
Genetic Testing Registry MYH13
NextProtQ9UKX3 [Medical]
TSGene8735
GENETestsMYH13
Target ValidationMYH13
Huge Navigator MYH13 [HugePedia]
snp3D : Map Gene to Disease8735
BioCentury BCIQMYH13
ClinGenMYH13
Clinical trials, drugs, therapy
Protein Interactions : CTD8735
Pharm GKB GenePA31368
Clinical trialMYH13
Miscellaneous
canSAR (ICR)MYH13 (select the gene name)
HarmonizomeMYH13
DataMed IndexMYH13
Probes
Litterature
PubMed17 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMYH13
EVEXMYH13
GoPubMedMYH13
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Jul 16 16:19:01 CEST 2020
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