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MYH4 (myosin heavy chain 4)

Identity

Alias_namesmyosin
Alias_symbol (synonym)MYH2B
MyHC-2B
MyHC-IIb
Other alias
HGNC (Hugo) MYH4
LocusID (NCBI) 4622
Atlas_Id 51072
Location 17p13.1  [Link to chromosome band 17p13]
Location_base_pair Starts at 10443291 and ends at 10469559 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)MYH4   7574
Cards
Entrez_Gene (NCBI)MYH4  4622  myosin heavy chain 4
AliasesMYH2B; MyHC-2B; MyHC-IIb
GeneCards (Weizmann)MYH4
Ensembl hg19 (Hinxton)ENSG00000264424 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000264424 [Gene_View]  chr17:10443291-10469559 [Contig_View]  MYH4 [Vega]
ICGC DataPortalENSG00000264424
TCGA cBioPortalMYH4
AceView (NCBI)MYH4
Genatlas (Paris)MYH4
WikiGenes4622
SOURCE (Princeton)MYH4
Genetics Home Reference (NIH)MYH4
Genomic and cartography
GoldenPath hg38 (UCSC)MYH4  -     chr17:10443291-10469559 -  17p13.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MYH4  -     17p13.1   [Description]    (hg19-Feb_2009)
EnsemblMYH4 - 17p13.1 [CytoView hg19]  MYH4 - 17p13.1 [CytoView hg38]
Mapping of homologs : NCBIMYH4 [Mapview hg19]  MYH4 [Mapview hg38]
OMIM160742   
Gene and transcription
Genbank (Entrez)AF111783 BC156394 BC157120
RefSeq transcript (Entrez)NM_017533
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)MYH4
Cluster EST : UnigeneHs.711141 [ NCBI ]
CGAP (NCI)Hs.711141
Alternative Splicing GalleryENSG00000264424
Gene ExpressionMYH4 [ NCBI-GEO ]   MYH4 [ EBI - ARRAY_EXPRESS ]   MYH4 [ SEEK ]   MYH4 [ MEM ]
Gene Expression Viewer (FireBrowse)MYH4 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4622
GTEX Portal (Tissue expression)MYH4
Human Protein AtlasENSG00000264424-MYH4 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9Y623   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9Y623  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9Y623
Splice isoforms : SwissVarQ9Y623
PhosPhoSitePlusQ9Y623
Domaine pattern : Prosite (Expaxy)IQ (PS50096)    MYOSIN_MOTOR (PS51456)   
Domains : Interpro (EBI)IQ_motif_EF-hand-BS    Myosin-like_IQ_dom    Myosin_head_motor_dom    Myosin_N    Myosin_tail    P-loop_NTPase   
Domain families : Pfam (Sanger)Myosin_head (PF00063)    Myosin_N (PF02736)    Myosin_tail_1 (PF01576)   
Domain families : Pfam (NCBI)pfam00063    pfam02736    pfam01576   
Domain families : Smart (EMBL)MYSc (SM00242)  
Conserved Domain (NCBI)MYH4
DMDM Disease mutations4622
Blocks (Seattle)MYH4
SuperfamilyQ9Y623
Human Protein Atlas [tissue]ENSG00000264424-MYH4 [tissue]
Peptide AtlasQ9Y623
HPRD08873
IPIIPI00001753   
Protein Interaction databases
DIP (DOE-UCLA)Q9Y623
IntAct (EBI)Q9Y623
FunCoupENSG00000264424
BioGRIDMYH4
STRING (EMBL)MYH4
ZODIACMYH4
Ontologies - Pathways
QuickGOQ9Y623
Ontology : AmiGOmicrofilament motor activity  double-stranded RNA binding  actin binding  calmodulin binding  ATP binding  muscle myosin complex  muscle contraction  response to activity  ATPase activity  myofibril  sarcomere  actin filament-based movement  muscle filament sliding  myosin filament  ATP metabolic process  
Ontology : EGO-EBImicrofilament motor activity  double-stranded RNA binding  actin binding  calmodulin binding  ATP binding  muscle myosin complex  muscle contraction  response to activity  ATPase activity  myofibril  sarcomere  actin filament-based movement  muscle filament sliding  myosin filament  ATP metabolic process  
Pathways : KEGGTight junction   
NDEx NetworkMYH4
Atlas of Cancer Signalling NetworkMYH4
Wikipedia pathwaysMYH4
Orthology - Evolution
OrthoDB4622
GeneTree (enSembl)ENSG00000264424
Phylogenetic Trees/Animal Genes : TreeFamMYH4
HOVERGENQ9Y623
HOGENOMQ9Y623
Homologs : HomoloGeneMYH4
Homology/Alignments : Family Browser (UCSC)MYH4
Gene fusions - Rearrangements
Fusion: Tumor Portal MYH4
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMYH4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MYH4
dbVarMYH4
ClinVarMYH4
1000_GenomesMYH4 
Exome Variant ServerMYH4
ExAC (Exome Aggregation Consortium)ENSG00000264424
GNOMAD BrowserENSG00000264424
Genetic variants : HAPMAP4622
Genomic Variants (DGV)MYH4 [DGVbeta]
DECIPHERMYH4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMYH4 
Mutations
ICGC Data PortalMYH4 
TCGA Data PortalMYH4 
Broad Tumor PortalMYH4
OASIS PortalMYH4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMYH4  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDMYH4
LOVD (Leiden Opån Va2iavion Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch MYH4
DgiDB (Drug Gene Interaction Database)MYH4
DoCM (Curated mutations)MYH4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MYH4 (select a term)
intoGenMYH4
Cancer3DMYH4(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM160742   
Orphanet
MedgenMYH4
Genetic Testing Registry MYH4
NextProtQ9Y623 [Medical]
TSGene4622
GENETestsMYH4
Target ValidationMYH4
Huge Navigator MYH4 [HugePedia]
snp3D : Map Gene to Disease4622
BioCentury BCIQMYH4
ClinGenMYH4
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD4622
Chemical/Pharm GKB GenePA31371
Clinical trialMYH4
Miscellaneous
canSAR (ICR)MYH4 (select the gene name)
Probes
Litterature
PubMed25 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMYH4
EVEXMYH4
GoPubMedMYH4
iHOPMYH4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Nov 9 13:01:40 CET 2017

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