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MYH7 (myosin, heavy chain 7, cardiac muscle, beta)

Identity

Other namesCMD1S
CMH1
MPD1
MYHCB
SPMD
SPMM
HGNC (Hugo) MYH7
LocusID (NCBI) 4625
Location 14q11.2
Location_base_pair Starts at 23881947 and ends at 23904870 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

External links

Nomenclature
HGNC (Hugo)MYH7   7577
Cards
Entrez_Gene (NCBI)MYH7  4625  myosin, heavy chain 7, cardiac muscle, beta
GeneCards (Weizmann)MYH7
Ensembl (Hinxton)ENSG00000092054 [Gene_View]  chr14:23881947-23904870 [Contig_View]  MYH7 [Vega]
AceView (NCBI)MYH7
Genatlas (Paris)MYH7
WikiGenes4625
SOURCE (Princeton)NM_000257
Genomic and cartography
GoldenPath (UCSC)MYH7  -  14q11.2   chr14:23881947-23904870 -  14q11.2   [Description]    (hg19-Feb_2009)
EnsemblMYH7 - 14q11.2 [CytoView]
Mapping of homologs : NCBIMYH7 [Mapview]
OMIM160500   160760   181430   192600   608358   613426   
Gene and transcription
Genbank (Entrez)AB209708 AJ710171 AK307590 AY518538 BC112171
RefSeq transcript (Entrez)NM_000257
RefSeq genomic (Entrez)AC_000146 NC_000014 NC_018925 NG_007884 NT_026437 NW_001838110 NW_004929393
Consensus coding sequences : CCDS (NCBI)MYH7
Cluster EST : UnigeneHs.719946 [ NCBI ]
CGAP (NCI)Hs.719946
Alternative Splicing : Fast-db (Paris)GSHG0009250
Alternative Splicing GalleryENSG00000092054
Gene ExpressionMYH7 [ NCBI-GEO ]     MYH7 [ SEEK ]   MYH7 [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP12883 (Uniprot)
NextProtP12883  [Medical]
With graphics : InterProP12883
Splice isoforms : SwissVarP12883 (Swissvar)
Domaine pattern : Prosite (Expaxy)IQ (PS50096)   
Domains : Interpro (EBI)IQ_motif_EF-hand-BS    Myosin-like_IQ_dom    Myosin_head_motor_dom    Myosin_N    Myosin_tail    P-loop_NTPase   
Related proteins : CluSTrP12883
Domain families : Pfam (Sanger)Myosin_head (PF00063)    Myosin_N (PF02736)    Myosin_tail_1 (PF01576)   
Domain families : Pfam (NCBI)pfam00063    pfam02736    pfam01576   
Domain families : Smart (EMBL)IQ (SM00015)  MYSc (SM00242)  
DMDM Disease mutations4625
Blocks (Seattle)P12883
PDB (SRS)1IK2    2FXM    2FXO    3DTP    4DB1   
PDB (PDBSum)1IK2    2FXM    2FXO    3DTP    4DB1   
PDB (IMB)1IK2    2FXM    2FXO    3DTP    4DB1   
PDB (RSDB)1IK2    2FXM    2FXO    3DTP    4DB1   
Human Protein AtlasENSG00000092054
Peptide AtlasP12883
HPRD01175
IPIIPI00025880   IPI01015436   
Protein Interaction databases
DIP (DOE-UCLA)P12883
IntAct (EBI)P12883
FunCoupENSG00000092054
BioGRIDMYH7
InParanoidP12883
Interologous Interaction database P12883
IntegromeDBMYH7
STRING (EMBL)MYH7
Ontologies - Pathways
Ontology : AmiGOmicrofilament motor activity  stress fiber  regulation of heart rate  actin binding  protein binding  calmodulin binding  ATP binding  nucleus  nucleolus  nucleolus  cytoplasm  muscle myosin complex  focal adhesion  ATP catabolic process  muscle contraction  muscle contraction  adult heart development  structural constituent of muscle  myosin complex  ATPase activity  sarcomere  Z disc  muscle filament sliding  actin-dependent ATPase activity  myosin filament  ventricular cardiac muscle tissue morphogenesis  
Ontology : EGO-EBImicrofilament motor activity  stress fiber  regulation of heart rate  actin binding  protein binding  calmodulin binding  ATP binding  nucleus  nucleolus  nucleolus  cytoplasm  muscle myosin complex  focal adhesion  ATP catabolic process  muscle contraction  muscle contraction  adult heart development  structural constituent of muscle  myosin complex  ATPase activity  sarcomere  Z disc  muscle filament sliding  actin-dependent ATPase activity  myosin filament  ventricular cardiac muscle tissue morphogenesis  
Pathways : KEGGCardiac muscle contraction    Adrenergic signaling in cardiomyocytes    Tight junction    Hypertrophic cardiomyopathy (HCM)    Dilated cardiomyopathy    Viral myocarditis   
REACTOMEMYH7
Protein Interaction DatabaseMYH7
Wikipedia pathwaysMYH7
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)MYH7
SNP (GeneSNP Utah)MYH7
SNP : HGBaseMYH7
Genetic variants : HAPMAPMYH7
1000_GenomesMYH7 
ICGC programENSG00000092054 
Somatic Mutations in Cancer : COSMICMYH7 
CONAN: Copy Number AnalysisMYH7 
Mutations and Diseases : HGMDMYH7
OMIM160500    160760    181430    192600    608358    613426   
GENETestsMYH7
Disease Genetic AssociationMYH7
Huge Navigator MYH7 [HugePedia]  MYH7 [HugeCancerGEM]
Genomic VariantsMYH7  MYH7 [DGVbeta]
Exome VariantMYH7
dbVarMYH7
ClinVarMYH7
snp3D : Map Gene to Disease4625
General knowledge
Homologs : HomoloGeneMYH7
Homology/Alignments : Family Browser (UCSC)MYH7
Phylogenetic Trees/Animal Genes : TreeFamMYH7
Chemical/Protein Interactions : CTD4625
Chemical/Pharm GKB GenePA31374
Clinical trialMYH7
Cancer Resource (Charite)ENSG00000092054
Other databases
Probes
Litterature
PubMed185 Pubmed reference(s) in Entrez
CoreMineMYH7
iHOPMYH7
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Apr 18 17:03:36 CEST 2014

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