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MYL3 (myosin, light chain 3, alkali; ventricular, skeletal, slow)

Identity

Other namesCMH8
MLC1SB
MLC1V
VLC1
HGNC (Hugo) MYL3
LocusID (NCBI) 4634
Location 3p21.31
Location_base_pair Starts at 46899357 and ends at 46904973 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)MYL3   7584
Cards
Entrez_Gene (NCBI)MYL3  4634  myosin, light chain 3, alkali; ventricular, skeletal, slow
GeneCards (Weizmann)MYL3
Ensembl (Hinxton)ENSG00000160808 [Gene_View]  chr3:46899357-46904973 [Contig_View]  MYL3 [Vega]
ICGC DataPortalENSG00000160808
cBioPortalMYL3
AceView (NCBI)MYL3
Genatlas (Paris)MYL3
WikiGenes4634
SOURCE (Princeton)NM_000258
Genomic and cartography
GoldenPath (UCSC)MYL3  -  3p21.31   chr3:46899357-46904973 -  3p21.31   [Description]    (hg19-Feb_2009)
EnsemblMYL3 - 3p21.31 [CytoView]
Mapping of homologs : NCBIMYL3 [Mapview]
OMIM160790   608751   
Gene and transcription
Genbank (Entrez)AF174483 AJ709328 AK312044 BC009790 BP316922
RefSeq transcript (Entrez)NM_000258
RefSeq genomic (Entrez)AC_000135 NC_000003 NC_018914 NG_007555 NT_022517 NW_001838877 NW_004929309
Consensus coding sequences : CCDS (NCBI)MYL3
Cluster EST : UnigeneHs.517939 [ NCBI ]
CGAP (NCI)Hs.517939
Alternative Splicing : Fast-db (Paris)GSHG0021673
Alternative Splicing GalleryENSG00000160808
Gene ExpressionMYL3 [ NCBI-GEO ]     MYL3 [ SEEK ]   MYL3 [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP08590 (Uniprot)
NextProtP08590  [Medical]
With graphics : InterProP08590
Splice isoforms : SwissVarP08590 (Swissvar)
Domaine pattern : Prosite (Expaxy)EF_HAND_2 (PS50222)   
Domains : Interpro (EBI)EF-hand-dom_pair [organisation]   EF_hand_dom [organisation]  
Related proteins : CluSTrP08590
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
DMDM Disease mutations4634
Blocks (Seattle)P08590
Human Protein AtlasENSG00000160808 [gene] [tissue] [antibody] [cell] [cancer]
Peptide AtlasP08590
HPRD01183
IPIIPI00243742   IPI00926541   
Protein Interaction databases
DIP (DOE-UCLA)P08590
IntAct (EBI)P08590
FunCoupENSG00000160808
BioGRIDMYL3
InParanoidP08590
Interologous Interaction database P08590
IntegromeDBMYL3
STRING (EMBL)MYL3
Ontologies - Pathways
Ontology : AmiGOregulation of the force of heart contraction  motor activity  actin monomer binding  calcium ion binding  cytosol  muscle myosin complex  regulation of striated muscle contraction  skeletal muscle tissue development  metabolic process  structural constituent of muscle  sarcomere  muscle filament sliding  A band  I band  myosin II heavy chain binding  positive regulation of ATPase activity  ventricular cardiac muscle tissue morphogenesis  cardiac muscle contraction  
Ontology : EGO-EBIregulation of the force of heart contraction  motor activity  actin monomer binding  calcium ion binding  cytosol  muscle myosin complex  regulation of striated muscle contraction  skeletal muscle tissue development  metabolic process  structural constituent of muscle  sarcomere  muscle filament sliding  A band  I band  myosin II heavy chain binding  positive regulation of ATPase activity  ventricular cardiac muscle tissue morphogenesis  cardiac muscle contraction  
Pathways : KEGGCardiac muscle contraction    Adrenergic signaling in cardiomyocytes    Hypertrophic cardiomyopathy (HCM)    Dilated cardiomyopathy   
Protein Interaction DatabaseMYL3
Wikipedia pathwaysMYL3
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)MYL3
snp3D : Map Gene to Disease4634
SNP (GeneSNP Utah)MYL3
SNP : HGBaseMYL3
Genetic variants : HAPMAPMYL3
Exome VariantMYL3
1000_GenomesMYL3 
ICGC programENSG00000160808 
Somatic Mutations in Cancer : COSMICMYL3 
CONAN: Copy Number AnalysisMYL3 
Mutations and Diseases : HGMDMYL3
Mutations and Diseases : intOGenMYL3
Genomic VariantsMYL3  MYL3 [DGVbeta]
dbVarMYL3
ClinVarMYL3
Pred. of missensesPolyPhen-2  SIFT(SG)  SIFT(JCVI)  Align-GVGD  MutAssessor  Mutanalyser  
Pred. splicesGeneSplicer  Human Splicing Finder  MaxEntScan  
Diseases
OMIM160790    608751   
MedgenMYL3
GENETestsMYL3
Disease Genetic AssociationMYL3
Huge Navigator MYL3 [HugePedia]  MYL3 [HugeCancerGEM]
General knowledge
Homologs : HomoloGeneMYL3
Homology/Alignments : Family Browser (UCSC)MYL3
Phylogenetic Trees/Animal Genes : TreeFamMYL3
Chemical/Protein Interactions : CTD4634
Chemical/Pharm GKB GenePA31381
Clinical trialMYL3
Cancer Resource (Charite)ENSG00000160808
Other databases
Probes
Litterature
PubMed43 Pubmed reference(s) in Entrez
CoreMineMYL3
iHOPMYL3
OncoSearchMYL3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Aug 26 16:56:54 CEST 2014

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