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MYL4 (myosin light chain 4)

Identity

Alias_namesmyosin, light polypeptide 4, alkali; atrial, embryonic
myosin, light chain 4, alkali; atrial, embryonic
Alias_symbol (synonym)ALC1
AMLC
GT1
PRO1957
Other alias
HGNC (Hugo) MYL4
LocusID (NCBI) 4635
Atlas_Id 70614
Location 17q21.32  [Link to chromosome band 17q21]
Location_base_pair Starts at 47209062 and ends at 47223679 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
CDC27 (17q21.32) / MYL4 (17q21.32)EFCAB13 (17q21.32) / MYL4 (17q21.32)FAM171A2 (17q21.31) / MYL4 (17q21.32)
C17orf57 MYL4CDC27 MYL4

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)MYL4   7585
Cards
Entrez_Gene (NCBI)MYL4  4635  myosin light chain 4
AliasesALC1; AMLC; GT1; PRO1957
GeneCards (Weizmann)MYL4
Ensembl hg19 (Hinxton)ENSG00000198336 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000198336 [Gene_View]  chr17:47209062-47223679 [Contig_View]  MYL4 [Vega]
ICGC DataPortalENSG00000198336
TCGA cBioPortalMYL4
AceView (NCBI)MYL4
Genatlas (Paris)MYL4
WikiGenes4635
SOURCE (Princeton)MYL4
Genetics Home Reference (NIH)MYL4
Genomic and cartography
GoldenPath hg38 (UCSC)MYL4  -     chr17:47209062-47223679 +  17q21.32   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MYL4  -     17q21.32   [Description]    (hg19-Feb_2009)
EnsemblMYL4 - 17q21.32 [CytoView hg19]  MYL4 - 17q21.32 [CytoView hg38]
Mapping of homologs : NCBIMYL4 [Mapview hg19]  MYL4 [Mapview hg38]
OMIM160770   617280   
Gene and transcription
Genbank (Entrez)AF116676 AM392523 AM392536 AM392902 AM393643
RefSeq transcript (Entrez)NM_001002841 NM_002476
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)MYL4
Cluster EST : UnigeneHs.463300 [ NCBI ]
CGAP (NCI)Hs.463300
Alternative Splicing GalleryENSG00000198336
Gene ExpressionMYL4 [ NCBI-GEO ]   MYL4 [ EBI - ARRAY_EXPRESS ]   MYL4 [ SEEK ]   MYL4 [ MEM ]
Gene Expression Viewer (FireBrowse)MYL4 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4635
GTEX Portal (Tissue expression)MYL4
Protein : pattern, domain, 3D structure
UniProt/SwissProtP12829   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP12829  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP12829
Splice isoforms : SwissVarP12829
PhosPhoSitePlusP12829
Domaine pattern : Prosite (Expaxy)EF_HAND_2 (PS50222)   
Domains : Interpro (EBI)EF-hand-dom_pair    EF_hand_dom   
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Conserved Domain (NCBI)MYL4
DMDM Disease mutations4635
Blocks (Seattle)MYL4
SuperfamilyP12829
Human Protein AtlasENSG00000198336
Peptide AtlasP12829
HPRD01176
IPIIPI00384992   IPI00386712   
Protein Interaction databases
DIP (DOE-UCLA)P12829
IntAct (EBI)P12829
FunCoupENSG00000198336
BioGRIDMYL4
STRING (EMBL)MYL4
ZODIACMYL4
Ontologies - Pathways
QuickGOP12829
Ontology : AmiGOregulation of the force of heart contraction  actin monomer binding  calcium ion binding  cytosol  myosin complex  muscle filament sliding  A band  myosin II heavy chain binding  positive regulation of ATPase activity  actin filament binding  cardiac muscle contraction  
Ontology : EGO-EBIregulation of the force of heart contraction  actin monomer binding  calcium ion binding  cytosol  myosin complex  muscle filament sliding  A band  myosin II heavy chain binding  positive regulation of ATPase activity  actin filament binding  cardiac muscle contraction  
Pathways : KEGGCardiac muscle contraction    Adrenergic signaling in cardiomyocytes   
NDEx NetworkMYL4
Atlas of Cancer Signalling NetworkMYL4
Wikipedia pathwaysMYL4
Orthology - Evolution
OrthoDB4635
GeneTree (enSembl)ENSG00000198336
Phylogenetic Trees/Animal Genes : TreeFamMYL4
HOVERGENP12829
HOGENOMP12829
Homologs : HomoloGeneMYL4
Homology/Alignments : Family Browser (UCSC)MYL4
Gene fusions - Rearrangements
Fusion: TCGAC17orf57 MYL4
Fusion: TCGACDC27 MYL4
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMYL4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MYL4
dbVarMYL4
ClinVarMYL4
1000_GenomesMYL4 
Exome Variant ServerMYL4
ExAC (Exome Aggregation Consortium)MYL4 (select the gene name)
Genetic variants : HAPMAP4635
Genomic Variants (DGV)MYL4 [DGVbeta]
DECIPHERMYL4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMYL4 
Mutations
ICGC Data PortalMYL4 
TCGA Data PortalMYL4 
Broad Tumor PortalMYL4
OASIS PortalMYL4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMYL4  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDMYL4
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch MYL4
DgiDB (Drug Gene Interaction Database)MYL4
DoCM (Curated mutations)MYL4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MYL4 (select a term)
intoGenMYL4
Cancer3DMYL4(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM160770    617280   
Orphanet
MedgenMYL4
Genetic Testing Registry MYL4
NextProtP12829 [Medical]
TSGene4635
GENETestsMYL4
Target ValidationMYL4
Huge Navigator MYL4 [HugePedia]
snp3D : Map Gene to Disease4635
BioCentury BCIQMYL4
ClinGenMYL4
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD4635
Chemical/Pharm GKB GenePA31382
Clinical trialMYL4
Miscellaneous
canSAR (ICR)MYL4 (select the gene name)
Probes
Litterature
PubMed28 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMYL4
EVEXMYL4
GoPubMedMYL4
iHOPMYL4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed May 31 15:32:02 CEST 2017

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