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MYL6 (myosin light chain 6)

Identity

Alias (NCBI)ESMLC
LC17
LC17-GI
LC17-NM
LC17A
LC17B
MLC-3
MLC1SM
MLC3NM
MLC3SM
HGNC (Hugo) MYL6
HGNC Alias symbESMLC
MLC3NM
MLC1SM
HGNC Previous namemyosin, light polypeptide 6, alkali, smooth muscle and non-muscle
 myosin, light chain 6, alkali, smooth muscle and non-muscle
LocusID (NCBI) 4637
Atlas_Id 70616
Location 12q13.2  [Link to chromosome band 12q13]
Location_base_pair Starts at 56158359 and ends at 56161579 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
MYL6 (12q13.2) / ARHGAP26 (5q31.3)MYL6 (12q13.2) / DST (6p12.1)MYL6 (12q13.2) / HMHA1 (19p13.3)
MYL6 (12q13.2) / SF3B2 (11q13.1)MYL6 (12q13.2) / ZNFX1 (20q13.13)NHS (Xp22.13) / MYL6 (12q13.2)
PSIP1 (9p22.3) / MYL6 (12q13.2)RPL37A (2q35) / MYL6 (12q13.2)MYL6 SF3B2
MYL6 ZNFX1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

 

Nomenclature
HGNC (Hugo)MYL6   7587
Cards
Entrez_Gene (NCBI)MYL6    myosin light chain 6
AliasesESMLC; LC17; LC17-GI; LC17-NM; 
LC17A; LC17B; MLC-3; MLC1SM; MLC3NM; MLC3SM
GeneCards (Weizmann)MYL6
Ensembl hg19 (Hinxton)ENSG00000092841 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000092841 [Gene_View]  ENSG00000092841 [Sequence]  chr12:56158359-56161579 [Contig_View]  MYL6 [Vega]
ICGC DataPortalENSG00000092841
TCGA cBioPortalMYL6
AceView (NCBI)MYL6
Genatlas (Paris)MYL6
SOURCE (Princeton)MYL6
Genetics Home Reference (NIH)MYL6
Genomic and cartography
GoldenPath hg38 (UCSC)MYL6  -     chr12:56158359-56161579 +  12q13.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MYL6  -     12q13.2   [Description]    (hg19-Feb_2009)
GoldenPathMYL6 - 12q13.2 [CytoView hg19]  MYL6 - 12q13.2 [CytoView hg38]
ImmunoBaseENSG00000092841
Genome Data Viewer NCBIMYL6 [Mapview hg19]  
OMIM609931   
Gene and transcription
Genbank (Entrez)AB046613 AK301198 BC006781 BC017455 BC071661
RefSeq transcript (Entrez)NM_021019 NM_079423 NM_079425
Consensus coding sequences : CCDS (NCBI)MYL6
Gene ExpressionMYL6 [ NCBI-GEO ]   MYL6 [ EBI - ARRAY_EXPRESS ]   MYL6 [ SEEK ]   MYL6 [ MEM ]
Gene Expression Viewer (FireBrowse)MYL6 [ Firebrowse - Broad ]
GenevisibleExpression of MYL6 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4637
GTEX Portal (Tissue expression)MYL6
Human Protein AtlasENSG00000092841-MYL6 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP60660   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP60660  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP60660
PhosPhoSitePlusP60660
Domaine pattern : Prosite (Expaxy)EF_HAND_2 (PS50222)   
Domains : Interpro (EBI)EF-hand-dom_pair    EF_hand_dom   
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Domain families : Smart (EMBL)EFh (SM00054)  
Conserved Domain (NCBI)MYL6
SuperfamilyP60660
AlphaFold pdb e-kbP60660   
Human Protein Atlas [tissue]ENSG00000092841-MYL6 [tissue]
HPRD17618
Protein Interaction databases
DIP (DOE-UCLA)P60660
IntAct (EBI)P60660
BioGRIDMYL6
STRING (EMBL)MYL6
ZODIACMYL6
Ontologies - Pathways
QuickGOP60660
Ontology : AmiGOmicrofilament motor activity  motor activity  calcium ion binding  protein binding  cytosol  brush border  muscle contraction  skeletal muscle tissue development  structural constituent of muscle  membrane  myosin complex  unconventional myosin complex  muscle filament sliding  vesicle  extracellular exosome  
Ontology : EGO-EBImicrofilament motor activity  motor activity  calcium ion binding  protein binding  cytosol  brush border  muscle contraction  skeletal muscle tissue development  structural constituent of muscle  membrane  myosin complex  unconventional myosin complex  muscle filament sliding  vesicle  extracellular exosome  
Pathways : KEGGTight junction    Leukocyte transendothelial migration    Focal adhesion   
NDEx NetworkMYL6
Atlas of Cancer Signalling NetworkMYL6
Wikipedia pathwaysMYL6
Orthology - Evolution
OrthoDB4637
GeneTree (enSembl)ENSG00000092841
Phylogenetic Trees/Animal Genes : TreeFamMYL6
Homologs : HomoloGeneMYL6
Homology/Alignments : Family Browser (UCSC)MYL6
Gene fusions - Rearrangements
Fusion : QuiverMYL6
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMYL6 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MYL6
dbVarMYL6
ClinVarMYL6
MonarchMYL6
1000_GenomesMYL6 
Exome Variant ServerMYL6
GNOMAD BrowserENSG00000092841
Varsome BrowserMYL6
ACMGMYL6 variants
VarityP60660
Genomic Variants (DGV)MYL6 [DGVbeta]
DECIPHERMYL6 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMYL6 
Mutations
ICGC Data PortalMYL6 
TCGA Data PortalMYL6 
Broad Tumor PortalMYL6
OASIS PortalMYL6 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMYL6  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DMYL6
Mutations and Diseases : HGMDMYL6
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaMYL6
DgiDB (Drug Gene Interaction Database)MYL6
DoCM (Curated mutations)MYL6
CIViC (Clinical Interpretations of Variants in Cancer)MYL6
Cancer3DMYL6
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM609931   
Orphanet
DisGeNETMYL6
MedgenMYL6
Genetic Testing Registry MYL6
NextProtP60660 [Medical]
GENETestsMYL6
Target ValidationMYL6
Huge Navigator MYL6 [HugePedia]
ClinGenMYL6
Clinical trials, drugs, therapy
MyCancerGenomeMYL6
Protein Interactions : CTDMYL6
Pharm GKB GenePA31384
PharosP60660
Clinical trialMYL6
Miscellaneous
canSAR (ICR)MYL6
HarmonizomeMYL6
DataMed IndexMYL6
Probes
Litterature
PubMed115 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXMYL6
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 16:12:10 CEST 2021
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