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MYL6 (myosin, light chain 6, alkali, smooth muscle and non-muscle)

Identity

Alias_namesmyosin, light polypeptide 6, alkali, smooth muscle and non-muscle
myosin, light chain 6, alkali, smooth muscle and non-muscle
Alias_symbol (synonym)ESMLC
MLC3NM
MLC1SM
Other aliasLC17
LC17-GI
LC17-NM
LC17A
LC17B
MLC-3
MLC3SM
HGNC (Hugo) MYL6
LocusID (NCBI) 4637
Atlas_Id 70616
Location 12q13.2  [Link to chromosome band 12q13]
Location_base_pair Starts at 56552045 and ends at 56555366 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
MYL6 (12q13.2) / ARHGAP26 (5q31.3)MYL6 (12q13.2) / DST (6p12.1)MYL6 (12q13.2) / HMHA1 (19p13.3)
MYL6 (12q13.2) / SF3B2 (11q13.1)MYL6 (12q13.2) / ZNFX1 (20q13.13)NHS (Xp22.13) / MYL6 (12q13.2)
PSIP1 (9p22.3) / MYL6 (12q13.2)RPL37A (2q35) / MYL6 (12q13.2)MYL6 SF3B2
MYL6 ZNFX1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)MYL6   7587
Cards
Entrez_Gene (NCBI)MYL6  4637  myosin, light chain 6, alkali, smooth muscle and non-muscle
AliasesESMLC; LC17; LC17-GI; LC17-NM; 
LC17A; LC17B; MLC-3; MLC1SM; MLC3NM; MLC3SM
GeneCards (Weizmann)MYL6
Ensembl hg19 (Hinxton)ENSG00000092841 [Gene_View]  chr12:56552045-56555366 [Contig_View]  MYL6 [Vega]
Ensembl hg38 (Hinxton)ENSG00000092841 [Gene_View]  chr12:56552045-56555366 [Contig_View]  MYL6 [Vega]
ICGC DataPortalENSG00000092841
TCGA cBioPortalMYL6
AceView (NCBI)MYL6
Genatlas (Paris)MYL6
WikiGenes4637
SOURCE (Princeton)MYL6
Genetics Home Reference (NIH)MYL6
Genomic and cartography
GoldenPath hg19 (UCSC)MYL6  -     chr12:56552045-56555366 +  12q13.2   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)MYL6  -     12q13.2   [Description]    (hg38-Dec_2013)
EnsemblMYL6 - 12q13.2 [CytoView hg19]  MYL6 - 12q13.2 [CytoView hg38]
Mapping of homologs : NCBIMYL6 [Mapview hg19]  MYL6 [Mapview hg38]
OMIM609931   
Gene and transcription
Genbank (Entrez)AB046613 AK301198 BC006781 BC017455 BC071661
RefSeq transcript (Entrez)NM_021019 NM_079423 NM_079425
RefSeq genomic (Entrez)NC_000012 NC_018923 NG_029223 NT_029419 NW_004929384
Consensus coding sequences : CCDS (NCBI)MYL6
Cluster EST : UnigeneHs.632717 [ NCBI ]
CGAP (NCI)Hs.632717
Alternative Splicing GalleryENSG00000092841
Gene ExpressionMYL6 [ NCBI-GEO ]   MYL6 [ EBI - ARRAY_EXPRESS ]   MYL6 [ SEEK ]   MYL6 [ MEM ]
Gene Expression Viewer (FireBrowse)MYL6 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4637
GTEX Portal (Tissue expression)MYL6
Protein : pattern, domain, 3D structure
UniProt/SwissProtP60660   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP60660  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP60660
Splice isoforms : SwissVarP60660
PhosPhoSitePlusP60660
Domaine pattern : Prosite (Expaxy)EF_HAND_2 (PS50222)   
Domains : Interpro (EBI)EF-hand-dom_pair    EF_hand_dom   
Domain families : Pfam (Sanger)EF-hand_6 (PF13405)   
Domain families : Pfam (NCBI)pfam13405   
Domain families : Smart (EMBL)EFh (SM00054)  
Conserved Domain (NCBI)MYL6
DMDM Disease mutations4637
Blocks (Seattle)MYL6
SuperfamilyP60660
Human Protein AtlasENSG00000092841
Peptide AtlasP60660
HPRD17618
IPIIPI00335168   IPI00789605   IPI00796366   IPI01022179   IPI01022653   IPI01022933   IPI01022437   IPI01022268   IPI01022767   IPI01021801   IPI01021962   IPI01021150   IPI01021004   IPI01021460   
Protein Interaction databases
DIP (DOE-UCLA)P60660
IntAct (EBI)P60660
FunCoupENSG00000092841
BioGRIDMYL6
STRING (EMBL)MYL6
ZODIACMYL6
Ontologies - Pathways
QuickGOP60660
Ontology : AmiGOmotor activity  calcium ion binding  protein binding  cytosol  brush border  muscle contraction  small GTPase mediated signal transduction  axon guidance  skeletal muscle tissue development  metabolic process  metabolic process  structural constituent of muscle  membrane  myosin complex  unconventional myosin complex  muscle filament sliding  actin-dependent ATPase activity  vesicle  ephrin receptor signaling pathway  extracellular exosome  
Ontology : EGO-EBImotor activity  calcium ion binding  protein binding  cytosol  brush border  muscle contraction  small GTPase mediated signal transduction  axon guidance  skeletal muscle tissue development  metabolic process  metabolic process  structural constituent of muscle  membrane  myosin complex  unconventional myosin complex  muscle filament sliding  actin-dependent ATPase activity  vesicle  ephrin receptor signaling pathway  extracellular exosome  
Pathways : KEGGVascular smooth muscle contraction   
NDEx NetworkMYL6
Atlas of Cancer Signalling NetworkMYL6
Wikipedia pathwaysMYL6
Orthology - Evolution
OrthoDB4637
GeneTree (enSembl)ENSG00000092841
Phylogenetic Trees/Animal Genes : TreeFamMYL6
HOVERGENP60660
HOGENOMP60660
Homologs : HomoloGeneMYL6
Homology/Alignments : Family Browser (UCSC)MYL6
Gene fusions - Rearrangements
Fusion: TCGAMYL6 SF3B2
Fusion: TCGAMYL6 ZNFX1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMYL6 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MYL6
dbVarMYL6
ClinVarMYL6
1000_GenomesMYL6 
Exome Variant ServerMYL6
ExAC (Exome Aggregation Consortium)MYL6 (select the gene name)
Genetic variants : HAPMAP4637
Genomic Variants (DGV)MYL6 [DGVbeta]
DECIPHER (Syndromes)12:56552045-56555366  ENSG00000092841
CONAN: Copy Number AnalysisMYL6 
Mutations
ICGC Data PortalMYL6 
TCGA Data PortalMYL6 
Broad Tumor PortalMYL6
OASIS PortalMYL6 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMYL6  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDMYL6
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch MYL6
DgiDB (Drug Gene Interaction Database)MYL6
DoCM (Curated mutations)MYL6 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MYL6 (select a term)
intoGenMYL6
Cancer3DMYL6(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM609931   
Orphanet
MedgenMYL6
Genetic Testing Registry MYL6
NextProtP60660 [Medical]
TSGene4637
GENETestsMYL6
Huge Navigator MYL6 [HugePedia]
snp3D : Map Gene to Disease4637
BioCentury BCIQMYL6
ClinGenMYL6
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD4637
Chemical/Pharm GKB GenePA31384
Clinical trialMYL6
Miscellaneous
canSAR (ICR)MYL6 (select the gene name)
Probes
Litterature
PubMed56 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMYL6
EVEXMYL6
GoPubMedMYL6
iHOPMYL6
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 12:34:17 CET 2017

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