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MYL6B (myosin light chain 6B)

Identity

Alias_namesmyosin, light polypeptide 6B, alkali, smooth muscle and non-muscle
myosin, light chain 6B, alkali, smooth muscle and non-muscle
Alias_symbol (synonym)MLC1SA
Other alias
HGNC (Hugo) MYL6B
LocusID (NCBI) 140465
Atlas_Id 70617
Location 12q13.2  [Link to chromosome band 12q13]
Location_base_pair Starts at 56152420 and ends at 56157987 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)MYL6B   29823
Cards
Entrez_Gene (NCBI)MYL6B  140465  myosin light chain 6B
AliasesMLC1SA
GeneCards (Weizmann)MYL6B
Ensembl hg19 (Hinxton)ENSG00000196465 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000196465 [Gene_View]  chr12:56152420-56157987 [Contig_View]  MYL6B [Vega]
ICGC DataPortalENSG00000196465
TCGA cBioPortalMYL6B
AceView (NCBI)MYL6B
Genatlas (Paris)MYL6B
WikiGenes140465
SOURCE (Princeton)MYL6B
Genetics Home Reference (NIH)MYL6B
Genomic and cartography
GoldenPath hg38 (UCSC)MYL6B  -     chr12:56152420-56157987 +  12q13.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MYL6B  -     12q13.2   [Description]    (hg19-Feb_2009)
EnsemblMYL6B - 12q13.2 [CytoView hg19]  MYL6B - 12q13.2 [CytoView hg38]
Mapping of homologs : NCBIMYL6B [Mapview hg19]  MYL6B [Mapview hg38]
OMIM609930   
Gene and transcription
Genbank (Entrez)AI349553 AK304594 AK310996 BC012425 BC014400
RefSeq transcript (Entrez)NM_001199629 NM_002475
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)MYL6B
Cluster EST : UnigeneHs.632731 [ NCBI ]
CGAP (NCI)Hs.632731
Alternative Splicing GalleryENSG00000196465
Gene ExpressionMYL6B [ NCBI-GEO ]   MYL6B [ EBI - ARRAY_EXPRESS ]   MYL6B [ SEEK ]   MYL6B [ MEM ]
Gene Expression Viewer (FireBrowse)MYL6B [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)140465
GTEX Portal (Tissue expression)MYL6B
Human Protein AtlasENSG00000196465-MYL6B [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP14649   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP14649  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP14649
Splice isoforms : SwissVarP14649
PhosPhoSitePlusP14649
Domaine pattern : Prosite (Expaxy)EF_HAND_2 (PS50222)   
Domains : Interpro (EBI)EF-hand-dom_pair    EF_hand_dom   
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Domain families : Smart (EMBL)EFh (SM00054)  
Conserved Domain (NCBI)MYL6B
DMDM Disease mutations140465
Blocks (Seattle)MYL6B
PDB (SRS)1OE9    1W7I    1W7J   
PDB (PDBSum)1OE9    1W7I    1W7J   
PDB (IMB)1OEšfnbqp;   1W7I    1W7J   
PDB (RSDB)1OE9    1W7I    1W7J   
Structural Biology KnowledgeBase1OE9    1W7I    1W7J   
SCOP (Structural Classification of Proteins)1OE9    1W7I    1W7J   
CATH (Classification of proteins structures)1OE9    1W7I    1W7J   
SuperfamilyP14649
Human Protein Atlas [tissue]ENSG00000196465-MYL6B [tissue]
Peptide AtlasP14649
HPRD14721
IPIIPI00027255   IPI00909366   IPI01021943   IPI01022065   
Protein Interaction databases
DIP (DOE-UCLA)P14649
IntAct (EBI)P14649
FunCoupENSG00000196465
BioGRIDMYL6B
STRING (EMBL)MYL6B
ZODIACMYL6B
Ontologies - Pathways
QuickGOP14649
Ontology : AmiGOmotor activity  calcium ion binding  protein binding  cytosol  muscle myosin complex  muscle contraction  skeletal muscle tissue development  structural constituent of muscle  myosin complex  unconventional myosin complex  muscle filament sliding  extracellular exosome  
Ontology : EGO-EBImotor activity  calcium ion binding  protein binding  cytosol  muscle myosin complex  muscle contraction  skeletal muscle tissue development  structural constituent of muscle  myosin complex  unconventional myosin complex  muscle filament sliding  extracellular exosome  
Pathways : KEGGVascular smooth muscle contraction   
NDEx NetworkMYL6B
Atlas of Cancer Signalling NetworkMYL6B
Wikipedia pathwaysMYL6B
Orthology - Evolution
OrthoDB140465
GeneTree (enSembl)ENSG00000196465
Phylogenetic Trees/Animal Genes : TreeFamMYL6B
HOVERGENP14649
HOGENOMP14649
Homologs : HomoloGeneMYL6B
Homology/Alignments : Family Browser (UCSC)MYL6B
Gene fusions - Rearrangements
Tumor Fusion PortalMYL6B
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMYL6B [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MYL6B
dbVarMYL6B
ClinVarMYL6B
1000_GenomesMYL6B 
Exome Variant ServerMYL6B
ExAC (Exome Aggregation Consortium)ENSG00000196465
GNOMAD BrowserENSG00000196465
Genetic variants : HAPMAP140465
Genomic Variants (DGV)MYL6B [DGVbeta]
DECIPHERMYL6B [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMYL6B 
Mutations
ICGC Data PortalMYL6B 
TCGA Data PortalMYL6B 
Broad Tumor PortalMYL6B
OASIS PortalMYL6B [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMYL6B  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDMYL6B
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch MYL6B
DgiDB (Drug Gene Interaction Database)MYL6B
DoCM (Curated mutations)MYL6B (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MYL6B (select a term)
intoGenMYL6B
Cancer3DMYL6B(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM609930   
Orphanet
DisGeNETMYL6B
MedgenMYL6B
Genetic Testing Registry MYL6B
NextProtP14649 [Medical]
TSGene140465
GENETestsMYL6B
Target ValidationMYL6B
Huge Navigator MYL6B [HugePedia]
snp3D : Map Gene to Disease140465
BioCentury BCIQMYL6B
ClinGenMYL6B
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD140465
Chemical/Pharm GKB GenePA144596407
Clinical trialMYL6B
Miscellaneous
canSAR (ICR)MYL6B (select the gene name)
Probes
Litterature
PubMed27 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMYL6B
EVEXMYL6B
GoPubMedMYL6B
iHOPMYL6B
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Nov 21 13:27:01 CET 2017

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