MYLK2 (myosin light chain kinase 2)

2006-10-01  

Identity

HGNC
LOCATION
20q11.21
LOCUSID
ALIAS
KMLC,MLCK,MLCK2,skMLCK

Other Information

Locus ID:

NCBI: 85366
MIM: 606566
HGNC: 16243
Ensembl: ENSG00000101306

Variants:

dbSNP: 85366
ClinVar: 85366
TCGA: ENSG00000101306
COSMIC: MYLK2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000101306ENST00000375985Q9H1R3
ENSG00000101306ENST00000375994Q9H1R3

Expression (GTEx)

0
50
100
150
200
250
300

Pathways

PathwaySourceExternal ID
Calcium signaling pathwayKEGGko04020
Focal adhesionKEGGko04510
Regulation of actin cytoskeletonKEGGko04810
Calcium signaling pathwayKEGGhsa04020
Focal adhesionKEGGhsa04510
Regulation of actin cytoskeletonKEGGhsa04810
Vascular smooth muscle contractionKEGGhsa04270
Vascular smooth muscle contractionKEGGko04270
Gastric acid secretionKEGGko04971
Gastric acid secretionKEGGhsa04971
Platelet activationKEGGhsa04611
Oxytocin signaling pathwayKEGGhsa04921
Oxytocin signaling pathwayKEGGko04921
cGMP-PKG signaling pathwayKEGGhsa04022
cGMP-PKG signaling pathwayKEGGko04022
Apelin signaling pathwayKEGGhsa04371

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
188281942008Variation in the myosin light chain kinase gene is associated with development of acute lung injury after major trauma.49
145007142003P2X1-mediated ERK2 activation amplifies the collagen-induced platelet secretion by enhancing myosin light chain kinase activation.12
196671952009Single-molecule force spectroscopy distinguishes target binding modes of calmodulin.10
258254562016Dual LQT1 and HCM phenotypes associated with tetrad heterozygous mutations in KCNQ1, MYH7, MYLK2, and TMEM70 genes in a three-generation Chinese family.5
164487862006Mutational analysis of the kinase domain of MYLK2 gene in common human cancers.3
164487862006Mutational analysis of the kinase domain of MYLK2 gene in common human cancers.3

Citation

Dessen P

MYLK2 (myosin light chain kinase 2)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43365/mylk2