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MYLK2 (myosin light chain kinase 2)

Identity

Alias_namesmyosin light chain kinase 2
Alias_symbol (synonym)skMLCK
KMLC
MLCK2
Other aliasMLCK
HGNC (Hugo) MYLK2
LocusID (NCBI) 85366
Atlas_Id 43365
Location 20q11.21  [Link to chromosome band 20q11]
Location_base_pair Starts at 31819375 and ends at 31834697 bp from pter ( according to hg38-Dec_2013)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)MYLK2   16243
LRG (Locus Reference Genomic)LRG_392
Cards
Entrez_Gene (NCBI)MYLK2  85366  myosin light chain kinase 2
AliasesKMLC; MLCK; MLCK2; skMLCK
GeneCards (Weizmann)MYLK2
Ensembl hg19 (Hinxton)ENSG00000101306 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000101306 [Gene_View]  chr20:31819375-31834697 [Contig_View]  MYLK2 [Vega]
ICGC DataPortalENSG00000101306
TCGA cBioPortalMYLK2
AceView (NCBI)MYLK2
Genatlas (Paris)MYLK2
WikiGenes85366
SOURCE (Princeton)MYLK2
Genetics Home Reference (NIH)MYLK2
Genomic and cartography
GoldenPath hg38 (UCSC)MYLK2  -     chr20:31819375-31834697 +  20q11.21   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MYLK2  -     20q11.21   [Description]    (hg19-Feb_2009)
EnsemblMYLK2 - 20q11.21 [CytoView hg19]  MYLK2 - 20q11.21 [CytoView hg38]
Mapping of homologs : NCBIMYLK2 [Mapview hg19]  MYLK2 [Mapview hg38]
OMIM192600   606566   
Gene and transcription
Genbank (Entrez)AF325549 AJ272502 BC007753 BC069627 BC092413
RefSeq transcript (Entrez)NM_033118
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)MYLK2
Cluster EST : UnigeneHs.86092 [ NCBI ]
CGAP (NCI)Hs.86092
Alternative Splicing GalleryENSG00000101306
Gene ExpressionMYLK2 [ NCBI-GEO ]   MYLK2 [ EBI - ARRAY_EXPRESS ]   MYLK2 [ SEEK ]   MYLK2 [ MEM ]
Gene Expression Viewer (FireBrowse)MYLK2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)85366
GTEX Portal (Tissue expression)MYLK2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9H1R3   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9H1R3  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9H1R3
Splice isoforms : SwissVarQ9H1R3
PhosPhoSitePlusQ9H1R3
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (EBI)Ca/CaM-dep_Ca-dep_prot_Kinase    Kinase-like_dom    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser/Thr_kinase_AS   
Domain families : Pfam (Sanger)Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam00069   
Domain families : Smart (EMBL)S_TKc (SM00220)  
Conserved Domain (NCBI)MYLK2
DMDM Disease mutations85366
Blocks (Seattle)MYLK2
PDB (SRS)2LV6    3KF9   
PDB (PDBSum)2LV6    3KF9   
PDB (IMB)2LV6    3KF9   
PDB (RSDB)2LV6    3KF9   
Structural Biology KnowledgeBase2LV6    3KF9   
SCOP (Structural Classification of Proteins)2LV6    3KF9   
CATH (Classification of proteins structures)2LV6    3KF9   
SuperfamilyQ9H1R3
Human Protein AtlasENSG00000101306
Peptide AtlasQ9H1R3
HPRD05953
IPIIPI00221127   
Protein Interaction databases
DIP (DOE-UCLA)Q9H1R3
IntAct (EBI)Q9H1R3
FunCoupENSG00000101306
BioGRIDMYLK2
STRING (EMBL)MYLK2
ZODIACMYLK2
Ontologies - Pathways
QuickGOQ9H1R3
Ontology : AmiGOcalmodulin-dependent protein kinase activity  myosin light chain kinase activity  myosin light chain kinase activity  protein binding  calmodulin binding  calmodulin binding  ATP binding  nucleus  cytoplasm  striated muscle contraction  neuromuscular synaptic transmission  positive regulation of gene expression  skeletal muscle satellite cell differentiation  peptidyl-serine phosphorylation  peptidyl-threonine phosphorylation  sarcomere  regulation of muscle filament sliding  intracellular signal transduction  skeletal muscle cell differentiation  protein autophosphorylation  cardiac muscle tissue morphogenesis  cardiac muscle contraction  
Ontology : EGO-EBIcalmodulin-dependent protein kinase activity  myosin light chain kinase activity  myosin light chain kinase activity  protein binding  calmodulin binding  calmodulin binding  ATP binding  nucleus  cytoplasm  striated muscle contraction  neuromuscular synaptic transmission  positive regulation of gene expression  skeletal muscle satellite cell differentiation  peptidyl-serine phosphorylation  peptidyl-threonine phosphorylation  sarcomere  regulation of muscle filament sliding  intracellular signal transduction  skeletal muscle cell differentiation  protein autophosphorylation  cardiac muscle tissue morphogenesis  cardiac muscle contraction  
Pathways : KEGGCalcium signaling pathway    Vascular smooth muscle contraction    Focal adhesion    Regulation of actin cytoskeleton    Gastric acid secretion   
NDEx NetworkMYLK2
Atlas of Cancer Signalling NetworkMYLK2
Wikipedia pathwaysMYLK2
Orthology - Evolution
OrthoDB85366
GeneTree (enSembl)ENSG00000101306
Phylogenetic Trees/Animal Genes : TreeFamMYLK2
HOVERGENQ9H1R3
HOGENOMQ9H1R3
Homologs : HomoloGeneMYLK2
Homology/Alignments : Family Browser (UCSC)MYLK2
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMYLK2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MYLK2
dbVarMYLK2
ClinVarMYLK2
1000_GenomesMYLK2 
Exome Variant ServerMYLK2
ExAC (Exome Aggregation Consortium)MYLK2 (select the gene name)
Genetic variants : HAPMAP85366
Genomic Variants (DGV)MYLK2 [DGVbeta]
DECIPHERMYLK2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMYLK2 
Mutations
ICGC Data PortalMYLK2 
TCGA Data PortalMYLK2 
Broad Tumor PortalMYLK2
OASIS PortalMYLK2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMYLK2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDMYLK2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch MYLK2
DgiDB (Drug Gene Interaction Database)MYLK2
DoCM (Curated mutations)MYLK2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MYLK2 (select a term)
intoGenMYLK2
Cancer3DMYLK2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM192600    606566   
Orphanet
MedgenMYLK2
Genetic Testing Registry MYLK2
NextProtQ9H1R3 [Medical]
TSGene85366
GENETestsMYLK2
Target ValidationMYLK2
Huge Navigator MYLK2 [HugePedia]
snp3D : Map Gene to Disease85366
BioCentury BCIQMYLK2
ClinGenMYLK2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD85366
Chemical/Pharm GKB GenePA31389
Clinical trialMYLK2
Miscellaneous
canSAR (ICR)MYLK2 (select the gene name)
Probes
Litterature
PubMed30 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMYLK2
EVEXMYLK2
GoPubMedMYLK2
iHOPMYLK2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 25 19:21:05 CEST 2017

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