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MYLK3 (myosin light chain kinase 3)

Identity

Alias_symbol (synonym)caMLCK
MLCK
Other aliasMLCK2
HGNC (Hugo) MYLK3
LocusID (NCBI) 91807
Atlas_Id 51891
Location 16q11.2  [Link to chromosome band 16q11]
Location_base_pair Starts at 46702282 and ends at 46763246 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
MYLK3 (16q11.2) / HSPA12B (20p13)VPS35 (16q11.2) / MYLK3 (16q11.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)MYLK3   29826
Cards
Entrez_Gene (NCBI)MYLK3  91807  myosin light chain kinase 3
AliasesMLCK; MLCK2; caMLCK
GeneCards (Weizmann)MYLK3
Ensembl hg19 (Hinxton)ENSG00000140795 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000140795 [Gene_View]  chr16:46702282-46763246 [Contig_View]  MYLK3 [Vega]
ICGC DataPortalENSG00000140795
TCGA cBioPortalMYLK3
AceView (NCBI)MYLK3
Genatlas (Paris)MYLK3
WikiGenes91807
SOURCE (Princeton)MYLK3
Genetics Home Reference (NIH)MYLK3
Genomic and cartography
GoldenPath hg38 (UCSC)MYLK3  -     chr16:46702282-46763246 -  16q11.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MYLK3  -     16q11.2   [Description]    (hg19-Feb_2009)
EnsemblMYLK3 - 16q11.2 [CytoView hg19]  MYLK3 - 16q11.2 [CytoView hg38]
Mapping of homologs : NCBIMYLK3 [Mapview hg19]  MYLK3 [Mapview hg38]
OMIM612147   
Gene and transcription
Genbank (Entrez)AB451455 AJ247087 AK299443 AL691746 BC039103
RefSeq transcript (Entrez)NM_001308301 NM_182493
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)MYLK3
Cluster EST : UnigeneHs.130465 [ NCBI ]
CGAP (NCI)Hs.130465
Alternative Splicing GalleryENSG00000140795
Gene ExpressionMYLK3 [ NCBI-GEO ]   MYLK3 [ EBI - ARRAY_EXPRESS ]   MYLK3 [ SEEK ]   MYLK3 [ MEM ]
Gene Expression Viewer (FireBrowse)MYLK3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)91807
GTEX Portal (Tissue expression)MYLK3
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ32MK0   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ32MK0  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ32MK0
Splice isoforms : SwissVarQ32MK0
Catalytic activity : Enzyme2.7.11.18 [ Enzyme-Expasy ]   2.7.11.182.7.11.18 [ IntEnz-EBI ]   2.7.11.18 [ BRENDA ]   2.7.11.18 [ KEGG ]   
PhosPhoSitePlusQ32MK0
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (EBI)Ca/CaM-dep_Ca-dep_prot_Kinase    Kinase-like_dom    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser/Thr_kinase_AS   
Domain families : Pfam (Sanger)Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam00069   
Domain families : Smart (EMBL)S_TKc (SM00220)  
Conserved Domain (NCBI)MYLK3
DMDM Disease mutations91807
Blocks (Seattle)MYLK3
SuperfamilyQ32MK0
Human Protein AtlasENSG00000140795
Peptide AtlasQ32MK0
HPRD11281
IPIIPI00304648   IPI01011040   
Protein Interaction databases
DIP (DOE-UCLA)Q32MK0
IntAct (EBI)Q32MK0
FunCoupENSG00000140795
BioGRIDMYLK3
STRING (EMBL)MYLK3
ZODIACMYLK3
Ontologies - Pathways
QuickGOQ32MK0
Ontology : AmiGOregulation of vascular permeability involved in acute inflammatory response  calmodulin-dependent protein kinase activity  myosin light chain kinase activity  myosin light chain kinase activity  ATP binding  intracellular  cytoplasm  cytosol  protein phosphorylation  actin cytoskeleton  peptidyl-serine phosphorylation  peptidyl-threonine phosphorylation  intracellular signal transduction  sarcomere organization  sarcomerogenesis  sarcomerogenesis  cardiac myofibril assembly  cardiac myofibril assembly  positive regulation of sarcomere organization  cellular response to interleukin-1  
Ontology : EGO-EBIregulation of vascular permeability involved in acute inflammatory response  calmodulin-dependent protein kinase activity  myosin light chain kinase activity  myosin light chain kinase activity  ATP binding  intracellular  cytoplasm  cytosol  protein phosphorylation  actin cytoskeleton  peptidyl-serine phosphorylation  peptidyl-threonine phosphorylation  intracellular signal transduction  sarcomere organization  sarcomerogenesis  sarcomerogenesis  cardiac myofibril assembly  cardiac myofibril assembly  positive regulation of sarcomere organization  cellular response to interleukin-1  
Pathways : KEGGCalcium signaling pathway    Vascular smooth muscle contraction    Focal adhesion    Regulation of actin cytoskeleton    Gastric acid secretion   
NDEx NetworkMYLK3
Atlas of Cancer Signalling NetworkMYLK3
Wikipedia pathwaysMYLK3
Orthology - Evolution
OrthoDB91807
GeneTree (enSembl)ENSG00000140795
Phylogenetic Trees/Animal Genes : TreeFamMYLK3
HOVERGENQ32MK0
HOGENOMQ32MK0
Homologs : HomoloGeneMYLK3
Homology/Alignments : Family Browser (UCSC)MYLK3
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMYLK3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MYLK3
dbVarMYLK3
ClinVarMYLK3
1000_GenomesMYLK3 
Exome Variant ServerMYLK3
ExAC (Exome Aggregation Consortium)MYLK3 (select the gene name)
Genetic variants : HAPMAP91807
Genomic Variants (DGV)MYLK3 [DGVbeta]
DECIPHERMYLK3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMYLK3 
Mutations
ICGC Data PortalMYLK3 
TCGA Data PortalMYLK3 
Broad Tumor PortalMYLK3
OASIS PortalMYLK3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMYLK3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDMYLK3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch MYLK3
DgiDB (Drug Gene Interaction Database)MYLK3
DoCM (Curated mutations)MYLK3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MYLK3 (select a term)
intoGenMYLK3
Cancer3DMYLK3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM612147   
Orphanet
MedgenMYLK3
Genetic Testing Registry MYLK3
NextProtQ32MK0 [Medical]
TSGene91807
GENETestsMYLK3
Target ValidationMYLK3
Huge Navigator MYLK3 [HugePedia]
snp3D : Map Gene to Disease91807
BioCentury BCIQMYLK3
ClinGenMYLK3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD91807
Chemical/Pharm GKB GenePA162396375
Clinical trialMYLK3
Miscellaneous
canSAR (ICR)MYLK3 (select the gene name)
Probes
Litterature
PubMed13 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMYLK3
EVEXMYLK3
GoPubMedMYLK3
iHOPMYLK3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Tue Aug 1 17:08:29 CEST 2017

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