MYLK3 (myosin light chain kinase 3)

2011-01-01  

Identity

HGNC
MYLK3
LOCATION
16q11.2
LOCUSID
91807
ALIAS
MLCK,MLCK2,caMLCK
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 91807
MIM: 612147
HGNC: 29826
Ensembl: ENSG00000140795

Variants:

dbSNP: 91807
ClinVar: 91807
TCGA: ENSG00000140795
COSMIC: MYLK3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000140795ENST00000394809Q32MK0
ENSG00000140795ENST00000536476Q32MK0

Expression (GTEx)

0
10
20
30
40
50
60
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Calcium signaling pathwayKEGGko04020
Focal adhesionKEGGko04510
Regulation of actin cytoskeletonKEGGko04810
Calcium signaling pathwayKEGGhsa04020
Focal adhesionKEGGhsa04510
Regulation of actin cytoskeletonKEGGhsa04810
Vascular smooth muscle contractionKEGGhsa04270
Vascular smooth muscle contractionKEGGko04270
Gastric acid secretionKEGGko04971
Gastric acid secretionKEGGhsa04971
Platelet activationKEGGhsa04611
Oxytocin signaling pathwayKEGGhsa04921
Oxytocin signaling pathwayKEGGko04921
cGMP-PKG signaling pathwayKEGGhsa04022
cGMP-PKG signaling pathwayKEGGko04022
Apelin signaling pathwayKEGGhsa04371

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
183907502008Mechanism of IL-1beta-induced increase in intestinal epithelial tight junction permeability.95
178856812007A cardiac myosin light chain kinase regulates sarcomere assembly in the vertebrate heart.60
247229042014Cyclic stretch disrupts apical junctional complexes in Caco-2 cell monolayers by a JNK-2-, c-Src-, and MLCK-dependent mechanism.22
238637512013Biochemical and physiological regulation of cardiac myocyte contraction by cardiac-specific myosin light chain kinase.7
292355292017Identification of MYLK3 mutations in familial dilated cardiomyopathy.7
235916262013Hepatitis B virus X protein disrupts stress fiber formation and triggers apoptosis.1

Citation

Dessen P

MYLK3 (myosin light chain kinase 3)

Atlas Genet Cytogenet Oncol Haematol. 2011-01-01

Online version: http://atlasgeneticsoncology.org/gene/51891/mylk3