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MYLK4 (myosin light chain kinase family member 4)

Identity

Alias_namesmyosin light chain kinase family, member 4
Alias_symbol (synonym)SgK085
Other alias
HGNC (Hugo) MYLK4
LocusID (NCBI) 340156
Atlas_Id 70620
Location 6p25.2  [Link to chromosome band 6p25]
Location_base_pair Starts at 2663629 and ends at 2750966 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)MYLK4   27972
Cards
Entrez_Gene (NCBI)MYLK4  340156  myosin light chain kinase family member 4
AliasesSgK085
GeneCards (Weizmann)MYLK4
Ensembl hg19 (Hinxton)ENSG00000145949 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000145949 [Gene_View]  ENSG00000145949 [Sequence]  chr6:2663629-2750966 [Contig_View]  MYLK4 [Vega]
ICGC DataPortalENSG00000145949
TCGA cBioPortalMYLK4
AceView (NCBI)MYLK4
Genatlas (Paris)MYLK4
WikiGenes340156
SOURCE (Princeton)MYLK4
Genetics Home Reference (NIH)MYLK4
Genomic and cartography
GoldenPath hg38 (UCSC)MYLK4  -     chr6:2663629-2750966 -  6p25.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MYLK4  -     6p25.2   [Description]    (hg19-Feb_2009)
EnsemblMYLK4 - 6p25.2 [CytoView hg19]  MYLK4 - 6p25.2 [CytoView hg38]
Mapping of homologs : NCBIMYLK4 [Mapview hg19]  MYLK4 [Mapview hg38]
Gene and transcription
Genbank (Entrez)AK090753 AK096893 AK122581 AK127360 BC132831
RefSeq transcript (Entrez)NM_001012418 NM_001347872
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)MYLK4
Cluster EST : UnigeneHs.127830 [ NCBI ]
CGAP (NCI)Hs.127830
Alternative Splicing GalleryENSG00000145949
Gene ExpressionMYLK4 [ NCBI-GEO ]   MYLK4 [ EBI - ARRAY_EXPRESS ]   MYLK4 [ SEEK ]   MYLK4 [ MEM ]
Gene Expression Viewer (FireBrowse)MYLK4 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)340156
GTEX Portal (Tissue expression)MYLK4
Human Protein AtlasENSG00000145949-MYLK4 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ86YV6   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ86YV6  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ86YV6
Splice isoforms : SwissVarQ86YV6
Catalytic activity : Enzyme2.7.11.1 [ Enzyme-Expasy ]   2.7.11.12.7.11.1 [ IntEnz-EBI ]   2.7.11.1 [ BRENDA ]   2.7.11.1 [ KEGG ]   
PhosPhoSitePlusQ86YV6
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (EBI)Ca/CaM-dep_Ca-dep_prot_Kinase    Kinase-like_dom    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser/Thr_kinase_AS   
Domain families : Pfam (Sanger)Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam00069   
Domain families : Smart (EMBL)S_TKc (SM00220)  
Conserved Domain (NCBI)MYLK4
DMDM Disease mutations340156
Blocks (Seattle)MYLK4
PDB (SRS)2X4F   
PDB (PDBSum)2X4F   
PDB (IMB)2X4F   
PDB (RSDB)2X4F   
Structural Biology KnowledgeBase2X4F   
SCOP (Structural Classification of Proteins)2X4F   
CATH (Classification of proteins structures)2X4F   
SuperfamilyQ86YV6
Human Protein Atlas [tissue]ENSG00000145949-MYLK4 [tissue]
Peptide AtlasQ86YV6
HPRD17355
IPIIPI01018630   IPI01013835   IPI00871561   
Protein Interaction databases
DIP (DOE-UCLA)Q86YV6
IntAct (EBI)Q86YV6
FunCoupENSG00000145949
BioGRIDMYLK4
STRING (EMBL)MYLK4
ZODIACMYLK4
Ontologies - Pathways
QuickGOQ86YV6
Ontology : AmiGOmyosin light chain kinase activity  ATP binding  intracellular  peptidyl-serine phosphorylation  peptidyl-threonine phosphorylation  intracellular signal transduction  extracellular exosome  
Ontology : EGO-EBImyosin light chain kinase activity  ATP binding  intracellular  peptidyl-serine phosphorylation  peptidyl-threonine phosphorylation  intracellular signal transduction  extracellular exosome  
Pathways : KEGGRegulation of actin cytoskeleton    Calcium signaling pathway    Focal adhesion   
NDEx NetworkMYLK4
Atlas of Cancer Signalling NetworkMYLK4
Wikipedia pathwaysMYLK4
Orthology - Evolution
OrthoDB340156
GeneTree (enSembl)ENSG00000145949
Phylogenetic Trees/Animal Genes : TreeFamMYLK4
HOVERGENQ86YV6
HOGENOMQ86YV6
Homologs : HomoloGeneMYLK4
Homology/Alignments : Family Browser (UCSC)MYLK4
Gene fusions - Rearrangements
Fusion : QuiverMYLK4
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMYLK4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MYLK4
dbVarMYLK4
ClinVarMYLK4
1000_GenomesMYLK4 
Exome Variant ServerMYLK4
ExAC (Exome Aggregation Consortium)ENSG00000145949
GNOMAD BrowserENSG00000145949
Varsome BrowserMYLK4
Genetic variants : HAPMAP340156
Genomic Variants (DGV)MYLK4 [DGVbeta]
DECIPHERMYLK4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMYLK4 
Mutations
ICGC Data PortalMYLK4 
TCGA Data PortalMYLK4 
Broad Tumor PortalMYLK4
OASIS PortalMYLK4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMYLK4  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDMYLK4
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch MYLK4
DgiDB (Drug Gene Interaction Database)MYLK4
DoCM (Curated mutations)MYLK4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MYLK4 (select a term)
intoGenMYLK4
Cancer3DMYLK4(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM
Orphanet
DisGeNETMYLK4
MedgenMYLK4
Genetic Testing Registry MYLK4
NextProtQ86YV6 [Medical]
TSGene340156
GENETestsMYLK4
Target ValidationMYLK4
Huge Navigator MYLK4 [HugePedia]
snp3D : Map Gene to Disease340156
BioCentury BCIQMYLK4
ClinGenMYLK4
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD340156
Chemical/Pharm GKB GenePA162396406
Clinical trialMYLK4
Miscellaneous
canSAR (ICR)MYLK4 (select the gene name)
Probes
Litterature
PubMed11 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMYLK4
EVEXMYLK4
GoPubMedMYLK4
iHOPMYLK4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Jul 30 14:19:10 CEST 2018

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