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MYO10 (myosin X)

Identity

Alias_symbol (synonym)KIAA0799
Other alias-
HGNC (Hugo) MYO10
LocusID (NCBI) 4651
Atlas_Id 53906
Location 5p15.1  [Link to chromosome band 5p15]
Location_base_pair Starts at 16662016 and ends at 16936385 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
LOC100506713 () / MYO10 (5p15.1)LOC100507246 () / MYO10 (5p15.1)MYO10 (5p15.1) / DNAH5 (5p15.2)
MYO10 (5p15.1) / FAM134B (5p15.1)MYO10 (5p15.1) / GPC5 (13q31.3)MYO10 (5p15.1) / MYO10 (5p15.1)
MYO10 (5p15.1) / SETX (9q34.13)MYO10 (5p15.1) / ST6GALNAC3 (1p31.1)MYOF (10q23.33) / MYO10 (5p15.1)
NIPBL (5p13.2) / MYO10 (5p15.1)PDIA3 (15q15.3) / MYO10 (5p15.1)MYO10 5p15.1 / DNAH5 5p15.2
MYO10 5p15.1 / ST6GALNAC3 1p31.1NIPBL 5p13.2 / MYO10 5p15.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)MYO10   7593
Cards
Entrez_Gene (NCBI)MYO10  4651  myosin X
Aliases
GeneCards (Weizmann)MYO10
Ensembl hg19 (Hinxton)ENSG00000145555 [Gene_View]  chr5:16662016-16936385 [Contig_View]  MYO10 [Vega]
Ensembl hg38 (Hinxton)ENSG00000145555 [Gene_View]  chr5:16662016-16936385 [Contig_View]  MYO10 [Vega]
ICGC DataPortalENSG00000145555
TCGA cBioPortalMYO10
AceView (NCBI)MYO10
Genatlas (Paris)MYO10
WikiGenes4651
SOURCE (Princeton)MYO10
Genetics Home Reference (NIH)MYO10
Genomic and cartography
GoldenPath hg19 (UCSC)MYO10  -     chr5:16662016-16936385 -  5p15.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)MYO10  -     5p15.1   [Description]    (hg38-Dec_2013)
EnsemblMYO10 - 5p15.1 [CytoView hg19]  MYO10 - 5p15.1 [CytoView hg38]
Mapping of homologs : NCBIMYO10 [Mapview hg19]  MYO10 [Mapview hg38]
OMIM601481   
Gene and transcription
Genbank (Entrez)AB018342 AF132021 AF132022 AF184153 AF234532
RefSeq transcript (Entrez)NM_012334
RefSeq genomic (Entrez)NC_000005 NC_018916 NT_006576 NW_004929321
Consensus coding sequences : CCDS (NCBI)MYO10
Cluster EST : UnigeneHs.481720 [ NCBI ]
CGAP (NCI)Hs.481720
Alternative Splicing GalleryENSG00000145555
Gene ExpressionMYO10 [ NCBI-GEO ]   MYO10 [ EBI - ARRAY_EXPRESS ]   MYO10 [ SEEK ]   MYO10 [ MEM ]
Gene Expression Viewer (FireBrowse)MYO10 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4651
GTEX Portal (Tissue expression)MYO10
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9HD67   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9HD67  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9HD67
Splice isoforms : SwissVarQ9HD67
PhosPhoSitePlusQ9HD67
Domaine pattern : Prosite (Expaxy)FERM_3 (PS50057)    IQ (PS50096)    MYOSIN_MOTOR (PS51456)    MYTH4 (PS51016)    PH_DOMAIN (PS50003)   
Domains : Interpro (EBI)Band_41_domain    FERM/acyl-CoA-bd_prot_3-hlx    FERM_central    FERM_domain    IQ_motif_EF-hand-BS    MYO10_CC    Myosin_head_motor_dom    MyTH4_dom    P-loop_NTPase    PH_dom-like    PH_domain    RA_dom   
Domain families : Pfam (Sanger)FERM_M (PF00373)    IQ (PF00612)    MYO10_CC (PF16735)    Myosin_head (PF00063)    MyTH4 (PF00784)    PH (PF00169)    RA (PF00788)   
Domain families : Pfam (NCBI)pfam00373    pfam00612    pfam16735    pfam00063    pfam00784    pfam00169    pfam00788   
Domain families : Smart (EMBL)B41 (SM00295)  IQ (SM00015)  MYSc (SM00242)  MyTH4 (SM00139)  PH (SM00233)  
Conserved Domain (NCBI)MYO10
DMDM Disease mutations4651
Blocks (Seattle)MYO10
PDB (SRS)2LW9    3AU4    3AU5    3PZD   
PDB (PDBSum)2LW9    3AU4    3AU5    3PZD   
PDB (IMB)2LW9    3AU4    3AU5    3PZD   
PDB (RSDB)2LW9    3AU4    3AU5    3PZD   
Structural Biology KnowledgeBase2LW9    3AU4    3AU5    3PZD   
SCOP (Structural Classification of Proteins)2LW9    3AU4    3AU5    3PZD   
CATH (Classification of proteins structures)2LW9    3AU4    3AU5    3PZD   
SuperfamilyQ9HD67
Human Protein AtlasENSG00000145555
Peptide AtlasQ9HD67
HPRD03283
IPIIPI01018912   IPI00940399   IPI00964074   IPI00964337   IPI00964606   
Protein Interaction databases
DIP (DOE-UCLA)Q9HD67
IntAct (EBI)Q9HD67
FunCoupENSG00000145555
BioGRIDMYO10
STRING (EMBL)MYO10
ZODIACMYO10
Ontologies - Pathways
QuickGOQ9HD67
Ontology : AmiGOruffle  motor activity  protein binding  calmodulin binding  ATP binding  phosphatidylinositol-3,4,5-trisphosphate binding  nucleolus  cytoplasm  cytosol  plasma membrane  cell cortex  metabolic process  regulation of cell shape  myosin complex  positive regulation of cell-cell adhesion  lamellipodium  spectrin binding  cytoskeleton-dependent intracellular transport  actin-dependent ATPase activity  filopodium membrane  filopodium tip  Fc-gamma receptor signaling pathway involved in phagocytosis  neuron projection  neuronal cell body  actin filament binding  regulation of filopodium assembly  plus-end directed microfilament motor activity  
Ontology : EGO-EBIruffle  motor activity  protein binding  calmodulin binding  ATP binding  phosphatidylinositol-3,4,5-trisphosphate binding  nucleolus  cytoplasm  cytosol  plasma membrane  cell cortex  metabolic process  regulation of cell shape  myosin complex  positive regulation of cell-cell adhesion  lamellipodium  spectrin binding  cytoskeleton-dependent intracellular transport  actin-dependent ATPase activity  filopodium membrane  filopodium tip  Fc-gamma receptor signaling pathway involved in phagocytosis  neuron projection  neuronal cell body  actin filament binding  regulation of filopodium assembly  plus-end directed microfilament motor activity  
Pathways : KEGGFc gamma R-mediated phagocytosis   
NDEx NetworkMYO10
Atlas of Cancer Signalling NetworkMYO10
Wikipedia pathwaysMYO10
Orthology - Evolution
OrthoDB4651
GeneTree (enSembl)ENSG00000145555
Phylogenetic Trees/Animal Genes : TreeFamMYO10
HOVERGENQ9HD67
HOGENOMQ9HD67
Homologs : HomoloGeneMYO10
Homology/Alignments : Family Browser (UCSC)MYO10
Gene fusions - Rearrangements
Fusion : MitelmanMYO10/DNAH5 [5p15.1/5p15.2]  
Fusion : MitelmanMYO10/ST6GALNAC3 [5p15.1/1p31.1]  [t(1;5)(p31;p15)]  
Fusion : MitelmanNIPBL/MYO10 [5p13.2/5p15.1]  [t(5;5)(p13;p15)]  
Fusion: TCGAMYO10 5p15.1 DNAH5 5p15.2 LUAD
Fusion: TCGAMYO10 5p15.1 ST6GALNAC3 1p31.1 LUAD
Fusion: TCGANIPBL 5p13.2 MYO10 5p15.1 LUAD
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMYO10 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MYO10
dbVarMYO10
ClinVarMYO10
1000_GenomesMYO10 
Exome Variant ServerMYO10
ExAC (Exome Aggregation Consortium)MYO10 (select the gene name)
Genetic variants : HAPMAP4651
Genomic Variants (DGV)MYO10 [DGVbeta]
DECIPHER (Syndromes)5:16662016-16936385  ENSG00000145555
CONAN: Copy Number AnalysisMYO10 
Mutations
ICGC Data PortalMYO10 
TCGA Data PortalMYO10 
Broad Tumor PortalMYO10
OASIS PortalMYO10 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMYO10  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDMYO10
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch MYO10
DgiDB (Drug Gene Interaction Database)MYO10
DoCM (Curated mutations)MYO10 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MYO10 (select a term)
intoGenMYO10
Cancer3DMYO10(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601481   
Orphanet
MedgenMYO10
Genetic Testing Registry MYO10
NextProtQ9HD67 [Medical]
TSGene4651
GENETestsMYO10
Huge Navigator MYO10 [HugePedia]
snp3D : Map Gene to Disease4651
BioCentury BCIQMYO10
ClinGenMYO10
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD4651
Chemical/Pharm GKB GenePA31394
Clinical trialMYO10
Miscellaneous
canSAR (ICR)MYO10 (select the gene name)
Probes
Litterature
PubMed49 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMYO10
EVEXMYO10
GoPubMedMYO10
iHOPMYO10
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Mar 30 15:11:26 CEST 2017

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