MYO18A (myosin XVIIIA)

2004-08-01  

Identity

HGNC
LOCATION
17q11.2
LOCUSID
ALIAS
MAJN,MYSPDZ,SP-R210,SPR210
FUSION GENES

Other Information

Locus ID:

NCBI: 399687
MIM: 610067
HGNC: 31104
Ensembl: ENSG00000196535

Variants:

dbSNP: 399687
ClinVar: 399687
TCGA: ENSG00000196535
COSMIC: MYO18A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000196535ENST00000527372Q92614
ENSG00000196535ENST00000528564H0YEV9
ENSG00000196535ENST00000530254E9PN42
ENSG00000196535ENST00000531253Q92614
ENSG00000196535ENST00000531253A0A024QZ63
ENSG00000196535ENST00000533112Q92614
ENSG00000196535ENST00000533420A0A1B0GWJ6
ENSG00000196535ENST00000588791K7EKB3
ENSG00000196535ENST00000628822A0A0D9SFK2
ENSG00000196535ENST00000636100A0A1B0GV45

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
100

Pathways

PathwaySourceExternal ID
DiseaseREACTOMER-HSA-1643685
Diseases of signal transductionREACTOMER-HSA-5663202
Signaling by FGFR in diseaseREACTOMER-HSA-1226099
Signaling by FGFR1 in diseaseREACTOMER-HSA-5655302
FGFR1 mutant receptor activationREACTOMER-HSA-1839124
Signaling by cytosolic FGFR1 fusion mutantsREACTOMER-HSA-1839117

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
198370352009GOLPH3 bridges phosphatidylinositol-4- phosphate and actomyosin to stretch and shape the Golgi to promote budding.153
244854522014DNA damage triggers Golgi dispersal via DNA-PK and GOLPH3.64
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
233455922013GOLPH3L antagonizes GOLPH3 to determine Golgi morphology.27
199233222010Identification of MYO18A as a novel interacting partner of the PAK2/betaPIX/GIT1 complex and its potential function in modulating epithelial cell migration.26
239904652013Functional characterization of human myosin-18A and its interaction with F-actin and GOLPH3.18
190060782009Identification of a MYO18A-PDGFRB fusion gene in an eosinophilia-associated atypical myeloproliferative neoplasm with a t(5;17)(q33-34;q11.2).7
158359062005The N-terminal domain of MYO18A has an ATP-insensitive actin-binding site.0
160876792005Identification of the surfactant protein A receptor 210 as the unconventional myosin 18A.0
184431882008An antibody against the surfactant protein A (SP-A)-binding domain of the SP-A receptor inhibits T cell-mediated immune responses to Mycobacterium tuberculosis.0

Citation

Dessen P

MYO18A (myosin XVIIIA)

Atlas Genet Cytogenet Oncol Haematol. 2004-08-01

Online version: http://atlasgeneticsoncology.org/gene/42921/myo18a