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MYO18A (myosin XVIIIA)

Identity

Alias (NCBI)MAJN
MYSPDZ
SP-R210
SPR210
HGNC (Hugo) MYO18A
HGNC Alias symbKIAA0216
MysPDZ
LocusID (NCBI) 399687
Atlas_Id 42921
Location 17q11.2  [Link to chromosome band 17q11]
Location_base_pair Starts at 29071123 and ends at 29180398 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CADM1 (11q23.3) / MYO18A (17q11.2)KIAA0100 (17q11.2) / MYO18A (17q11.2)MYO18A (17q11.2) / ABCC1 (16p13.11)
MYO18A (17q11.2) / ALB (4q13.3)MYO18A (17q11.2) / EIF4G1 (3q27.1)MYO18A (17q11.2) / FGFR1 (8p11.23)
MYO18A (17q11.2) / KMT2A (11q23.3)MYO18A (17q11.2) / MSI2 (17q22)MYO18A (17q11.2) / MYO18A (17q11.2)
MYO18A (17q11.2) / NUFIP2 (17q11.2)MYO18A (17q11.2) / PDGFRB (5q32)MYO18A (17q11.2) / RNF135 (17q11.2)
MYO18A (17q11.2) / SERGEF (11p15.1)MYO18A (17q11.2) / ZBTB46 (20q13.33)PHF12 (17q11.2) / MYO18A (17q11.2)
RNF169 (11q13.4) / MYO18A (17q11.2)TOP3A (17p11.2) / MYO18A (17q11.2)MYO18A 17q11.2 / MSI2 17q22
MYO18A 17q11.2 / NUFIP2 17q11.2MYO18A 17q11.2 / RNF135 17q11.2MYO18A 17q11.2 / SERGEF 11p15.1
MYO18A 17q11.2 / ZBTB46 20q13.33TOP3A 17p11.2 / MYO18A 17q11.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



Other Leukemias implicated (Data extracted from papers in the Atlas) [ 4 ]
  8p11 myeloproliferative syndrome (FGFR1)
t(8;17)(p11;q23) MYO18A/FGFR1
t(5;17)(q32;q11) MYO18A/PDGFRB
t(5;17)(q33-34;q11.2) PDGFRB/MYO18A


External links

 

Nomenclature
HGNC (Hugo)MYO18A   31104
Cards
Entrez_Gene (NCBI)MYO18A    myosin XVIIIA
AliasesMAJN; MYSPDZ; SP-R210; SPR210
GeneCards (Weizmann)MYO18A
Ensembl hg19 (Hinxton)ENSG00000196535 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000196535 [Gene_View]  ENSG00000196535 [Sequence]  chr17:29071123-29180398 [Contig_View]  MYO18A [Vega]
ICGC DataPortalENSG00000196535
TCGA cBioPortalMYO18A
AceView (NCBI)MYO18A
Genatlas (Paris)MYO18A
SOURCE (Princeton)MYO18A
Genetics Home Reference (NIH)MYO18A
Genomic and cartography
GoldenPath hg38 (UCSC)MYO18A  -     chr17:29071123-29180398 -  17q11.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MYO18A  -     17q11.2   [Description]    (hg19-Feb_2009)
GoldenPathMYO18A - 17q11.2 [CytoView hg19]  MYO18A - 17q11.2 [CytoView hg38]
ImmunoBaseENSG00000196535
Genome Data Viewer NCBIMYO18A [Mapview hg19]  
OMIM610067   
Gene and transcription
Genbank (Entrez)AB177858 AB177860 AF252258 AK122870 AK294180
RefSeq transcript (Entrez)NM_001346765 NM_001346766 NM_001346767 NM_001346768 NM_078471 NM_203318
Consensus coding sequences : CCDS (NCBI)MYO18A
Gene ExpressionMYO18A [ NCBI-GEO ]   MYO18A [ EBI - ARRAY_EXPRESS ]   MYO18A [ SEEK ]   MYO18A [ MEM ]
Gene Expression Viewer (FireBrowse)MYO18A [ Firebrowse - Broad ]
GenevisibleExpression of MYO18A in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)399687
GTEX Portal (Tissue expression)MYO18A
Human Protein AtlasENSG00000196535-MYO18A [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ92614   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ92614  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ92614
PhosPhoSitePlusQ92614
Domaine pattern : Prosite (Expaxy)IQ (PS50096)    MYOSIN_MOTOR (PS51456)    PDZ (PS50106)    SH3_LIKE (PS51844)   
Domains : Interpro (EBI)IQ_motif_EF-hand-BS    Kinesin_motor_dom_sf    MYO18A    Myosin_head_motor_dom    Myosin_IQ_contain_sf    Myosin_N    Myosin_tail    MYSc_Myo18    P-loop_NTPase    PDZ    PDZ_6    PDZ_sf    RecA_monomer-monomer_interface   
Domain families : Pfam (Sanger)Myosin_head (PF00063)    Myosin_tail_1 (PF01576)    PDZ_6 (PF17820)   
Domain families : Pfam (NCBI)pfam00063    pfam01576    pfam17820   
Domain families : Smart (EMBL)IQ (SM00015)  MYSc (SM00242)  PDZ (SM00228)  
Conserved Domain (NCBI)MYO18A
SuperfamilyQ92614
AlphaFold pdb e-kbQ92614   
Human Protein Atlas [tissue]ENSG00000196535-MYO18A [tissue]
HPRD10106
Protein Interaction databases
DIP (DOE-UCLA)Q92614
IntAct (EBI)Q92614
BioGRIDMYO18A
STRING (EMBL)MYO18A
ZODIACMYO18A
Ontologies - Pathways
QuickGOQ92614
Ontology : AmiGOGolgi membrane  DNA binding  RNA binding  protein binding  ATP binding  endoplasmic reticulum-Golgi intermediate compartment  trans-Golgi network  DNA metabolic process  Golgi organization  ATPase, acting on DNA  cell surface  membrane  myosin complex  cell migration  actomyosin structure organization  actomyosin  regulation of macrophage activation  negative regulation of apoptotic process  ADP binding  Golgi vesicle budding  positive regulation of protein secretion  actin filament binding  Golgi ribbon formation  asymmetric Golgi ribbon formation  ATP hydrolysis activity  positive regulation of opsonization  
Ontology : EGO-EBIGolgi membrane  DNA binding  RNA binding  protein binding  ATP binding  endoplasmic reticulum-Golgi intermediate compartment  trans-Golgi network  DNA metabolic process  Golgi organization  ATPase, acting on DNA  cell surface  membrane  myosin complex  cell migration  actomyosin structure organization  actomyosin  regulation of macrophage activation  negative regulation of apoptotic process  ADP binding  Golgi vesicle budding  positive regulation of protein secretion  actin filament binding  Golgi ribbon formation  asymmetric Golgi ribbon formation  ATP hydrolysis activity  positive regulation of opsonization  
NDEx NetworkMYO18A
Atlas of Cancer Signalling NetworkMYO18A
Wikipedia pathwaysMYO18A
Orthology - Evolution
OrthoDB399687
GeneTree (enSembl)ENSG00000196535
Phylogenetic Trees/Animal Genes : TreeFamMYO18A
Homologs : HomoloGeneMYO18A
Homology/Alignments : Family Browser (UCSC)MYO18A
Gene fusions - Rearrangements
Fusion : MitelmanKIAA0100/MYO18A [17q11.2/17q11.2]  
Fusion : MitelmanMYO18A/FGFR1 [17q11.2/8p11.23]  
Fusion : MitelmanMYO18A/MSI2 [17q11.2/17q22]  
Fusion : MitelmanMYO18A/NUFIP2 [17q11.2/17q11.2]  
Fusion : MitelmanMYO18A/PDGFRB [17q11.2/5q32]  
Fusion : MitelmanMYO18A/RNF135 [17q11.2/17q11.2]  
Fusion : MitelmanMYO18A/SERGEF [17q11.2/11p15.1]  
Fusion : MitelmanMYO18A/ZBTB46 [17q11.2/20q13.33]  
Fusion : MitelmanTOP3A/MYO18A [17p11.2/17q11.2]  
Fusion : QuiverMYO18A
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMYO18A [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MYO18A
dbVarMYO18A
ClinVarMYO18A
MonarchMYO18A
1000_GenomesMYO18A 
Exome Variant ServerMYO18A
GNOMAD BrowserENSG00000196535
Varsome BrowserMYO18A
ACMGMYO18A variants
VarityQ92614
Genomic Variants (DGV)MYO18A [DGVbeta]
DECIPHERMYO18A [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMYO18A 
Mutations
ICGC Data PortalMYO18A 
TCGA Data PortalMYO18A 
Broad Tumor PortalMYO18A
OASIS PortalMYO18A [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMYO18A  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DMYO18A
Mutations and Diseases : HGMDMYO18A
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaMYO18A
DgiDB (Drug Gene Interaction Database)MYO18A
DoCM (Curated mutations)MYO18A
CIViC (Clinical Interpretations of Variants in Cancer)MYO18A
Cancer3DMYO18A
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM610067   
Orphanet
DisGeNETMYO18A
MedgenMYO18A
Genetic Testing Registry MYO18A
NextProtQ92614 [Medical]
GENETestsMYO18A
Target ValidationMYO18A
Huge Navigator MYO18A [HugePedia]
ClinGenMYO18A
Clinical trials, drugs, therapy
MyCancerGenomeMYO18A
Protein Interactions : CTDMYO18A
Pharm GKB GenePA134978348
PharosQ92614
Clinical trialMYO18A
Miscellaneous
canSAR (ICR)MYO18A
HarmonizomeMYO18A
DataMed IndexMYO18A
Probes
Litterature
PubMed64 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXMYO18A
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Oct 4 15:21:48 CEST 2021

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