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MYO1C (myosin IC)

Identity

Alias_symbol (synonym)myr2
Other aliasMMI-beta
MMIb
NMI
HGNC (Hugo) MYO1C
LocusID (NCBI) 4641
Atlas_Id 52278
Location 17p13.3  [Link to chromosome band 17p13]
Location_base_pair Starts at 1464186 and ends at 1492707 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
COL1A2 (7q21.3) / MYO1C (17p13.3)CYP19A1 (15q21.2) / MYO1C (17p13.3)MYO1C (17p13.3) / CRK (17p13.3)
MYO1C (17p13.3) / IFT22 (7q22.1)MYO1C (17p13.3) / MYO1C (17p13.3)MYO1C (17p13.3) / SLC43A2 (17p13.3)
MYO1C (17p13.3) / SNW1 (14q24.3)RNF41 (12q13.2) / MYO1C (17p13.3)RNF41 12q13.2 / MYO1C 17p13.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)MYO1C   7597
Cards
Entrez_Gene (NCBI)MYO1C  4641  myosin IC
AliasesMMI-beta; MMIb; NMI; myr2
GeneCards (Weizmann)MYO1C
Ensembl hg19 (Hinxton)ENSG00000197879 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000197879 [Gene_View]  chr17:1464186-1492707 [Contig_View]  MYO1C [Vega]
ICGC DataPortalENSG00000197879
TCGA cBioPortalMYO1C
AceView (NCBI)MYO1C
Genatlas (Paris)MYO1C
WikiGenes4641
SOURCE (Princeton)MYO1C
Genetics Home Reference (NIH)MYO1C
Genomic and cartography
GoldenPath hg38 (UCSC)MYO1C  -     chr17:1464186-1492707 -  17p13.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MYO1C  -     17p13.3   [Description]    (hg19-Feb_2009)
EnsemblMYO1C - 17p13.3 [CytoView hg19]  MYO1C - 17p13.3 [CytoView hg38]
Mapping of homologs : NCBIMYO1C [Mapview hg19]  MYO1C [Mapview hg38]
OMIM606538   
Gene and transcription
Genbank (Entrez)AB210015 AI220881 AK172742 AK292910 AK295761
RefSeq transcript (Entrez)NM_001080779 NM_001080950 NM_033375
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)MYO1C
Cluster EST : UnigeneHs.286226 [ NCBI ]
CGAP (NCI)Hs.286226
Alternative Splicing GalleryENSG00000197879
Gene ExpressionMYO1C [ NCBI-GEO ]   MYO1C [ EBI - ARRAY_EXPRESS ]   MYO1C [ SEEK ]   MYO1C [ MEM ]
Gene Expression Viewer (FireBrowse)MYO1C [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4641
GTEX Portal (Tissue expression)MYO1C
Protein : pattern, domain, 3D structure
UniProt/SwissProtO00159   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO00159  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO00159
Splice isoforms : SwissVarO00159
PhosPhoSitePlusO00159
Domaine pattern : Prosite (Expaxy)IQ (PS50096)    MYOSIN_MOTOR (PS51456)    TH1 (PS51757)   
Domains : Interpro (EBI)IQ_motif_EF-hand-BS    Myosin_head_motor_dom    Myosin_TH1    P-loop_NTPase   
Domain families : Pfam (Sanger)IQ (PF00612)    Myosin_head (PF00063)    Myosin_TH1 (PF06017)   
Domain families : Pfam (NCBI)pfam00612    pfam00063    pfam06017   
Domain families : Smart (EMBL)IQ (SM00015)  MYSc (SM00242)  
Conserved Domain (NCBI)MYO1C
DMDM Disease mutations4641
Blocks (Seattle)MYO1C
PDB (SRS)4BYF   
PDB (PDBSum)4BYF   
PDB (IMB)4BYF   
PDB (RSDB)4BYF   
Structural Biology KnowledgeBase4BYF   
SCOP (Structural Classification of Proteins)4BYF   
CATH (Classification of proteins structures)4BYF   
SuperfamilyO00159
Human Protein AtlasENSG00000197879
Peptide AtlasO00159
HPRD09411
IPIIPI00743335   IPI00010418   IPI00829992   IPI01012564   IPI01009308   IPI01009754   
Protein Interaction databases
DIP (DOE-UCLA)O00159
IntAct (EBI)O00159
FunCoupENSG00000197879
BioGRIDMYO1C
STRING (EMBL)MYO1C
ZODIACMYO1C
Ontologies - Pathways
QuickGOO00159
Ontology : AmiGOmicrofilament motor activity  stress fiber  receptor binding  protein binding  calmodulin binding  ATP binding  nuclear pore  nucleoplasm  nucleolus  cytoplasm  cytosol  plasma membrane  microvillus  brush border  protein targeting  protein targeting to membrane  protein C-terminus binding  basal plasma membrane  membrane  lateral plasma membrane  unconventional myosin complex  nuclear body  Ral GTPase binding  positive regulation of cell migration  positive regulation of actin filament polymerization  actin-dependent ATPase activity  cytoplasmic vesicle  filamentous actin  stereocilium  ruffle membrane  positive regulation of cell migration by vascular endothelial growth factor signaling pathway  Fc-gamma receptor signaling pathway involved in phagocytosis  membrane raft  myosin I complex  positive regulation of gene expression, epigenetic  actin filament binding  mRNA transport  stereocilium membrane  extracellular exosome  positive regulation of protein targeting to membrane  positive regulation of cellular response to insulin stimulus  positive regulation of vascular endothelial growth factor signaling pathway  regulation of bicellular tight junction assembly  
Ontology : EGO-EBImicrofilament motor activity  stress fiber  receptor binding  protein binding  calmodulin binding  ATP binding  nuclear pore  nucleoplasm  nucleolus  cytoplasm  cytosol  plasma membrane  microvillus  brush border  protein targeting  protein targeting to membrane  protein C-terminus binding  basal plasma membrane  membrane  lateral plasma membrane  unconventional myosin complex  nuclear body  Ral GTPase binding  positive regulation of cell migration  positive regulation of actin filament polymerization  actin-dependent ATPase activity  cytoplasmic vesicle  filamentous actin  stereocilium  ruffle membrane  positive regulation of cell migration by vascular endothelial growth factor signaling pathway  Fc-gamma receptor signaling pathway involved in phagocytosis  membrane raft  myosin I complex  positive regulation of gene expression, epigenetic  actin filament binding  mRNA transport  stereocilium membrane  extracellular exosome  positive regulation of protein targeting to membrane  positive regulation of cellular response to insulin stimulus  positive regulation of vascular endothelial growth factor signaling pathway  regulation of bicellular tight junction assembly  
NDEx NetworkMYO1C
Atlas of Cancer Signalling NetworkMYO1C
Wikipedia pathwaysMYO1C
Orthology - Evolution
OrthoDB4641
GeneTree (enSembl)ENSG00000197879
Phylogenetic Trees/Animal Genes : TreeFamMYO1C
HOVERGENO00159
HOGENOMO00159
Homologs : HomoloGeneMYO1C
Homology/Alignments : Family Browser (UCSC)MYO1C
Gene fusions - Rearrangements
Fusion : MitelmanRNF41/MYO1C [12q13.2/17p13.3]  [t(12;17)(q13;p13)]  
Fusion: TCGARNF41 12q13.2 MYO1C 17p13.3 OV
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMYO1C [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MYO1C
dbVarMYO1C
ClinVarMYO1C
1000_GenomesMYO1C 
Exome Variant ServerMYO1C
ExAC (Exome Aggregation Consortium)MYO1C (select the gene name)
Genetic variants : HAPMAP4641
Genomic Variants (DGV)MYO1C [DGVbeta]
DECIPHERMYO1C [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMYO1C 
Mutations
ICGC Data PortalMYO1C 
TCGA Data PortalMYO1C 
Broad Tumor PortalMYO1C
OASIS PortalMYO1C [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMYO1C  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDMYO1C
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch MYO1C
DgiDB (Drug Gene Interaction Database)MYO1C
DoCM (Curated mutations)MYO1C (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MYO1C (select a term)
intoGenMYO1C
Cancer3DMYO1C(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606538   
Orphanet12046   
MedgenMYO1C
Genetic Testing Registry MYO1C
NextProtO00159 [Medical]
TSGene4641
GENETestsMYO1C
Target ValidationMYO1C
Huge Navigator MYO1C [HugePedia]
snp3D : Map Gene to Disease4641
BioCentury BCIQMYO1C
ClinGenMYO1C
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD4641
Chemical/Pharm GKB GenePA31399
Clinical trialMYO1C
Miscellaneous
canSAR (ICR)MYO1C (select the gene name)
Probes
Litterature
PubMed70 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMYO1C
EVEXMYO1C
GoPubMedMYO1C
iHOPMYO1C
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Jun 7 12:45:51 CEST 2017

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