Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumours   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

MYO6 (myosin VI)

Identity

Other namesDFNA22
DFNB37
HGNC (Hugo) MYO6
LocusID (NCBI) 4646
Atlas_Id 46347
Location 6q14.1
Location_base_pair Starts at 76458893 and ends at 76629254 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2015)
MYO6 6q14.1 / NEGR1 1p31.1MYO6 6q14.1 / SENP6 6q14.1S100A8 1q21.3 / MYO6 6q14.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)MYO6   7605
Cards
Entrez_Gene (NCBI)MYO6  4646  myosin VI
GeneCards (Weizmann)MYO6
Ensembl hg19 (Hinxton)ENSG00000196586 [Gene_View]  chr6:76458893-76629254 [Contig_View]  MYO6 [Vega]
Ensembl hg38 (Hinxton)ENSG00000196586 [Gene_View]  chr6:76458893-76629254 [Contig_View]  MYO6 [Vega]
ICGC DataPortalENSG00000196586
TCGA cBioPortalMYO6
AceView (NCBI)MYO6
Genatlas (Paris)MYO6
WikiGenes4646
SOURCE (Princeton)MYO6
Genomic and cartography
GoldenPath hg19 (UCSC)MYO6  -     chr6:76458893-76629254 +  6q14.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)MYO6  -     6q14.1   [Description]    (hg38-Dec_2013)
EnsemblMYO6 - 6q14.1 [CytoView hg19]  MYO6 - 6q14.1 [CytoView hg38]
Mapping of homologs : NCBIMYO6 [Mapview hg19]  MYO6 [Mapview hg38]
OMIM600970   606346   607821   
Gene and transcription
Genbank (Entrez)AB002387 AK095294 BC012598 BC146764 BX647397
RefSeq transcript (Entrez)NM_001300899 NM_004999
RefSeq genomic (Entrez)NC_000006 NC_018917 NG_009934 NT_025741 NW_004929327
Consensus coding sequences : CCDS (NCBI)MYO6
Cluster EST : UnigeneHs.149387 [ NCBI ]
CGAP (NCI)Hs.149387
Alternative Splicing : Fast-db (Paris)GSHG0025852
Alternative Splicing GalleryENSG00000196586
Gene ExpressionMYO6 [ NCBI-GEO ]     MYO6 [ SEEK ]   MYO6 [ MEM ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
BioGPS (Tissue expression)4646
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UM54 (Uniprot)
NextProtQ9UM54  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9UM54
Splice isoforms : SwissVarQ9UM54 (Swissvar)
PhosPhoSitePlusQ9UM54
Domaine pattern : Prosite (Expaxy)MYOSIN_MOTOR (PS51456)   
Domains : Interpro (EBI)IQ_motif_EF-hand-BS    Myosin_head_motor_dom    P-loop_NTPase   
Domain families : Pfam (Sanger)Myosin_head (PF00063)   
Domain families : Pfam (NCBI)pfam00063   
Domain families : Smart (EMBL)IQ (SM00015)  MYSc (SM00242)  
DMDM Disease mutations4646
Blocks (Seattle)MYO6
Human Protein AtlasENSG00000196586
Peptide AtlasQ9UM54
HPRD02985
IPIIPI00069126   IPI00008455   IPI00816461   IPI00642722   IPI00941711   IPI00816452   IPI00844172   IPI00552641   
Protein Interaction databases
DIP (DOE-UCLA)Q9UM54
IntAct (EBI)Q9UM54
FunCoupENSG00000196586
BioGRIDMYO6
IntegromeDBMYO6
STRING (EMBL)MYO6
ZODIACMYO6
Ontologies - Pathways
QuickGOQ9UM54
Ontology : AmiGOruffle  motor activity  actin binding  protein binding  calmodulin binding  calmodulin binding  ATP binding  nucleus  nucleoplasm  cytoplasm  cytoplasm  lysosomal membrane  Golgi apparatus  cytosol  plasma membrane  microvillus  coated pit  cell cortex  protein targeting  intracellular protein transport  endocytosis  endocytosis  synaptic transmission  synapse assembly  sensory perception of sound  locomotory behavior  metabolic process  glutamate secretion  membrane  cytoplasmic membrane-bounded vesicle  dendrite development  unconventional myosin complex  DNA-directed RNA polymerase II, holoenzyme  actin filament-based movement  actin filament-based movement  endocytic vesicle  DNA damage response, signal transduction by p53 class mediator  axon  clathrin-coated vesicle membrane  filamentous actin  filamentous actin  nuclear membrane  ruffle membrane  inner ear morphogenesis  auditory receptor cell differentiation  response to drug  neuronal cell body  ADP binding  apical part of cell  clathrin-coated endocytic vesicle  positive regulation of transcription from RNA polymerase II promoter  regulation of synaptic plasticity  perinuclear region of cytoplasm  perinuclear region of cytoplasm  actin filament binding  actin filament binding  regulation of secretion  minus-end directed microfilament motor activity  membrane organization  extracellular exosome  cellular response to electrical stimulus  
Ontology : EGO-EBIruffle  motor activity  actin binding  protein binding  calmodulin binding  calmodulin binding  ATP binding  nucleus  nucleoplasm  cytoplasm  cytoplasm  lysosomal membrane  Golgi apparatus  cytosol  plasma membrane  microvillus  coated pit  cell cortex  protein targeting  intracellular protein transport  endocytosis  endocytosis  synaptic transmission  synapse assembly  sensory perception of sound  locomotory behavior  metabolic process  glutamate secretion  membrane  cytoplasmic membrane-bounded vesicle  dendrite development  unconventional myosin complex  DNA-directed RNA polymerase II, holoenzyme  actin filament-based movement  actin filament-based movement  endocytic vesicle  DNA damage response, signal transduction by p53 class mediator  axon  clathrin-coated vesicle membrane  filamentous actin  filamentous actin  nuclear membrane  ruffle membrane  inner ear morphogenesis  auditory receptor cell differentiation  response to drug  neuronal cell body  ADP binding  apical part of cell  clathrin-coated endocytic vesicle  positive regulation of transcription from RNA polymerase II promoter  regulation of synaptic plasticity  perinuclear region of cytoplasm  perinuclear region of cytoplasm  actin filament binding  actin filament binding  regulation of secretion  minus-end directed microfilament motor activity  membrane organization  extracellular exosome  cellular response to electrical stimulus  
Protein Interaction DatabaseMYO6
Atlas of Cancer Signalling NetworkMYO6
Wikipedia pathwaysMYO6
Orthology - Evolution
OrthoDB4646
GeneTree (enSembl)ENSG00000196586
Phylogenetic Trees/Animal Genes : TreeFamMYO6
Homologs : HomoloGeneMYO6
Homology/Alignments : Family Browser (UCSC)MYO6
Gene fusions - Rearrangements
Fusion: TCGAMYO6 6q14.1 NEGR1 1p31.1 PRAD
Fusion: TCGAMYO6 6q14.1 SENP6 6q14.1 BRCA HNSC LUAD
Fusion: TCGAS100A8 1q21.3 MYO6 6q14.1 HNSC
Polymorphisms : SNP, variants
NCBI Variation ViewerMYO6 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MYO6
dbVarMYO6
ClinVarMYO6
1000_GenomesMYO6 
Exome Variant ServerMYO6
Exome Aggregation Consortium (ExAC)ENSG00000196586
SNP (GeneSNP Utah)MYO6
SNP : HGBaseMYO6
Genetic variants : HAPMAPMYO6
Genomic Variants (DGV)MYO6 [DGVbeta]
Mutations
ICGC Data PortalMYO6 
TCGA Data PortalMYO6 
Tumor PortalMYO6
TCGA Copy Number PortalMYO6
Somatic Mutations in Cancer : COSMICMYO6 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)**PUBLIC** CCHMC Molecular Genetics Laboratory Mutation Database
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch MYO6
DgiDB (Drug Gene Interaction Database)MYO6
DoCM (Curated mutations)MYO6 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MYO6 (select a term)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)6:76458893-76629254
CONAN: Copy Number AnalysisMYO6 
Mutations and Diseases : HGMDMYO6
OMIM600970    606346    607821   
MedgenMYO6
NextProtQ9UM54 [Medical]
TSGene4646
GENETestsMYO6
Huge Navigator MYO6 [HugePedia]  MYO6 [HugeCancerGEM]
snp3D : Map Gene to Disease4646
BioCentury BCIQMYO6
General knowledge
Chemical/Protein Interactions : CTD4646
Chemical/Pharm GKB GenePA31410
Clinical trialMYO6
Other databases
Probes
Litterature
PubMed100 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMYO6
GoPubMedMYO6
iHOPMYO6
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Jan 16 19:06:38 CET 2016

Home   Genes   Leukemias   Solid Tumours   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.