MYO6 (myosin VI)

2007-02-01  

Identity

HGNC
LOCATION
6q14.1
LOCUSID
ALIAS
DFNA22,DFNB37
FUSION GENES

Other Information

Locus ID:

NCBI: 4646
MIM: 600970
HGNC: 7605
Ensembl: ENSG00000196586

Variants:

dbSNP: 4646
ClinVar: 4646
TCGA: ENSG00000196586
COSMIC: MYO6

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000196586ENST00000369975A0A0A0MRM8
ENSG00000196586ENST00000369977Q9UM54
ENSG00000196586ENST00000369981E7EW20
ENSG00000196586ENST00000369985Q9UM54
ENSG00000196586ENST00000430435Q5JVM0
ENSG00000196586ENST00000462633A0A590UJW9
ENSG00000196586ENST00000615563Q9UM54
ENSG00000196586ENST00000627432A0A0D9SGC1
ENSG00000196586ENST00000653423A0A590UK22
ENSG00000196586ENST00000653917A0A590UJY4
ENSG00000196586ENST00000660420A0A590UJ48
ENSG00000196586ENST00000662184A0A590UK71
ENSG00000196586ENST00000662603A0A590UJ75
ENSG00000196586ENST00000663400A0A590UK86
ENSG00000196586ENST00000664209A0A590UKB0
ENSG00000196586ENST00000664640A0A590UJ40
ENSG00000196586ENST00000672093A0A1Y0BRN3

Expression (GTEx)

0
5
10
15
20
25
30
35

Pathways

PathwaySourceExternal ID
Neuronal SystemREACTOMER-HSA-112316
Transmission across Chemical SynapsesREACTOMER-HSA-112315
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic CellREACTOMER-HSA-112314
Glutamate Binding, Activation of AMPA Receptors and Synaptic PlasticityREACTOMER-HSA-399721
Trafficking of AMPA receptorsREACTOMER-HSA-399719
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
Gap junction trafficking and regulationREACTOMER-HSA-157858
Gap junction traffickingREACTOMER-HSA-190828
Gap junction degradationREACTOMER-HSA-190873

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
230232242012Autophagy receptors link myosin VI to autophagosomes to mediate Tom1-dependent autophagosome maturation and fusion with the lysosome.106
171870612007Myosin VI targeting to clathrin-coated structures and dimerization is mediated by binding to Disabled-2 and PtdIns(4,5)P2.98
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
203539992010The microRNA profile of prostate carcinoma obtained by deep sequencing.78
180294002007Myosin VI and its interacting protein LMTK2 regulate tubule formation and transport to the endocytic recycling compartment.66
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
170716052006A novel role of myosin VI in human prostate cancer.58
126874992003Mutations of MYO6 are associated with recessive deafness, DFNB37.56
264519152015The Autophagy Receptor TAX1BP1 and the Molecular Motor Myosin VI Are Required for Clearance of Salmonella Typhimurium by Autophagy.56
151460662004Lessons from border cell migration in the Drosophila ovary: A role for myosin VI in dissemination of human ovarian cancer.47

Citation

Dessen P

MYO6 (myosin VI)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46347/myo6