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MYO9A (myosin IXA)

Identity

Alias (NCBI)CMS24
HGNC (Hugo) MYO9A
HGNC Alias symbFLJ11061
FLJ13244
MGC71859
LocusID (NCBI) 4649
Atlas_Id 70635
Location 15q23  [Link to chromosome band 15q23]
Location_base_pair Starts at 71826020 and ends at 72118099 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
MYO9A (15q23) / CELF6 (15q23)MYO9A (15q23) / CRAMP1 (16p13.3)MYO9A (15q23) / GRAMD2 (15q23)
MYO9A (15q23) / HEXA (15q23)MYO9A (15q23) / TMEM59 (1p32.3)MYO9A (15q23) / ZYG11B (1p32.3)
MYO9A CELF6MYO9A TMEM59MYO9A CRAMP1L
MYO9A HEXA

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 2 ]
  t(1;15)(p32;q23) MYO9A/TMEM59
t(2;15)(q32;q23) MYO9A/PMS1


External links

Nomenclature
HGNC (Hugo)MYO9A   7608
Cards
Entrez_Gene (NCBI)MYO9A    myosin IXA
AliasesCMS24
GeneCards (Weizmann)MYO9A
Ensembl hg19 (Hinxton)ENSG00000066933 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000066933 [Gene_View]  ENSG00000066933 [Sequence]  chr15:71826020-72118099 [Contig_View]  MYO9A [Vega]
ICGC DataPortalENSG00000066933
TCGA cBioPortalMYO9A
AceView (NCBI)MYO9A
Genatlas (Paris)MYO9A
SOURCE (Princeton)MYO9A
Genetics Home Reference (NIH)MYO9A
Genomic and cartography
GoldenPath hg38 (UCSC)MYO9A  -     chr15:71826020-72118099 -  15q23   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MYO9A  -     15q23   [Description]    (hg19-Feb_2009)
GoldenPathMYO9A - 15q23 [CytoView hg19]  MYO9A - 15q23 [CytoView hg38]
ImmunoBaseENSG00000066933
genome Data Viewer NCBIMYO9A [Mapview hg19]  
OMIM604875   618198   
Gene and transcription
Genbank (Entrez)AB209841 AB290183 AF117888 AJ001714 AK001923
RefSeq transcript (Entrez)NM_006901
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)MYO9A
Alternative Splicing GalleryENSG00000066933
Gene ExpressionMYO9A [ NCBI-GEO ]   MYO9A [ EBI - ARRAY_EXPRESS ]   MYO9A [ SEEK ]   MYO9A [ MEM ]
Gene Expression Viewer (FireBrowse)MYO9A [ Firebrowse - Broad ]
GenevisibleExpression of MYO9A in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4649
GTEX Portal (Tissue expression)MYO9A
Human Protein AtlasENSG00000066933-MYO9A [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtB2RTY4   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtB2RTY4  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProB2RTY4
Splice isoforms : SwissVarB2RTY4
PhosPhoSitePlusB2RTY4
Domaine pattern : Prosite (Expaxy)IQ (PS50096)    MYOSIN_MOTOR (PS51456)    RA (PS50200)    RHOGAP (PS50238)    ZF_DAG_PE_1 (PS00479)    ZF_DAG_PE_2 (PS50081)   
Domains : Interpro (EBI)IQ_motif_EF-hand-BS    Kinesin_motor_dom_sf    MYO9A    Myosin_head_motor_dom    MYSc_Myo9    P-loop_NTPase    PE/DAG-bd    RA_dom    Rho_GTPase_activation_prot    RhoGAP_dom    Ubiquitin-like_domsf   
Domain families : Pfam (Sanger)IQ (PF00612)    Myosin_head (PF00063)    RA (PF00788)    RhoGAP (PF00620)   
Domain families : Pfam (NCBI)pfam00612    pfam00063    pfam00788    pfam00620   
Domain families : Smart (EMBL)C1 (SM00109)  IQ (SM00015)  MYSc (SM00242)  RA (SM00314)  RhoGAP (SM00324)  
Conserved Domain (NCBI)MYO9A
Blocks (Seattle)MYO9A
SuperfamilyB2RTY4
Human Protein Atlas [tissue]ENSG00000066933-MYO9A [tissue]
Peptide AtlasB2RTY4
HPRD05341
IPIIPI00953559   IPI00160131   IPI00902852   IPI00018057   IPI00902943   IPI00921217   
Protein Interaction databases
DIP (DOE-UCLA)B2RTY4
IntAct (EBI)B2RTY4
BioGRIDMYO9A
STRING (EMBL)MYO9A
ZODIACMYO9A
Ontologies - Pathways
QuickGOB2RTY4
Ontology : AmiGOmotor activity  actin binding  GTPase activator activity  protein binding  ATP binding  cytosol  visual perception  integral component of membrane  unconventional myosin complex  cell junction  cell junction assembly  intracellular signal transduction  positive regulation of GTPase activity  axonal growth cone  establishment of epithelial cell apical/basal polarity  synapse  metal ion binding  regulation of small GTPase mediated signal transduction  regulation of neuron projection arborization  
Ontology : EGO-EBImotor activity  actin binding  GTPase activator activity  protein binding  ATP binding  cytosol  visual perception  integral component of membrane  unconventional myosin complex  cell junction  cell junction assembly  intracellular signal transduction  positive regulation of GTPase activity  axonal growth cone  establishment of epithelial cell apical/basal polarity  synapse  metal ion binding  regulation of small GTPase mediated signal transduction  regulation of neuron projection arborization  
NDEx NetworkMYO9A
Atlas of Cancer Signalling NetworkMYO9A
Wikipedia pathwaysMYO9A
Orthology - Evolution
OrthoDB4649
GeneTree (enSembl)ENSG00000066933
Phylogenetic Trees/Animal Genes : TreeFamMYO9A
HOGENOMB2RTY4
Homologs : HomoloGeneMYO9A
Homology/Alignments : Family Browser (UCSC)MYO9A
Gene fusions - Rearrangements
Fusion PortalMYO9A CELF6
Fusion PortalMYO9A TMEM59
Fusion PortalMYO9A CRAMP1L
Fusion PortalMYO9A HEXA
Fusion : QuiverMYO9A
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMYO9A [hg38]
dbVarMYO9A
ClinVarMYO9A
MonarchMYO9A
1000_GenomesMYO9A 
Exome Variant ServerMYO9A
GNOMAD BrowserENSG00000066933
Varsome BrowserMYO9A
Genomic Variants (DGV)MYO9A [DGVbeta]
DECIPHERMYO9A [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMYO9A 
Mutations
ICGC Data PortalMYO9A 
TCGA Data PortalMYO9A 
Broad Tumor PortalMYO9A
OASIS PortalMYO9A [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMYO9A  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DMYO9A
Mutations and Diseases : HGMDMYO9A
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch MYO9A
DgiDB (Drug Gene Interaction Database)MYO9A
DoCM (Curated mutations)MYO9A (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MYO9A (select a term)
intoGenMYO9A
Cancer3DMYO9A(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604875    618198   
Orphanet
DisGeNETMYO9A
MedgenMYO9A
Genetic Testing Registry MYO9A
NextProtB2RTY4 [Medical]
GENETestsMYO9A
Target ValidationMYO9A
Huge Navigator MYO9A [HugePedia]
ClinGenMYO9A
Clinical trials, drugs, therapy
MyCancerGenomeMYO9A
Protein Interactions : CTD
Pharm GKB GenePA31413
Clinical trialMYO9A
Miscellaneous
canSAR (ICR)MYO9A (select the gene name)
HarmonizomeMYO9A
DataMed IndexMYO9A
Probes
Litterature
PubMed34 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMYO9A
EVEXMYO9A
GoPubMedMYO9A
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Dec 5 17:18:33 CET 2020

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