MYOCD (myocardin)

2010-03-01  

Identity

HGNC
MYOCD
LOCATION
17p12
LOCUSID
93649
ALIAS
MGBL,MYCD

Other Information

Locus ID:

NCBI: 93649
MIM: 606127
HGNC: 16067
Ensembl: ENSG00000141052

Variants:

dbSNP: 93649
ClinVar: 93649
TCGA: ENSG00000141052
COSMIC: MYOCD

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000141052ENST00000343344Q8IZQ8
ENSG00000141052ENST00000425538Q8IZQ8
ENSG00000141052ENST00000443061Q6N065
ENSG00000141052ENST00000579237J3KSX3

Expression (GTEx)

0
10
20
30
40
50
60
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
126401262003Myocardin is a critical serum response factor cofactor in the transcriptional program regulating smooth muscle cell differentiation.134
190989032009SRF and myocardin regulate LRP-mediated amyloid-beta clearance in brain vascular cells.100
172153562007Serum response factor and myocardin mediate arterial hypercontractility and cerebral blood flow dysregulation in Alzheimer's phenotype.76
187721302008Foxo3a inhibits cardiomyocyte hypertrophy through transactivating catalase.66
210516632011Induction of microRNA-1 by myocardin in smooth muscle cells inhibits cell proliferation.48
184513342008Myocardin is sufficient for a smooth muscle-like contractile phenotype.47
161510172005HERP1 inhibits myocardin-induced vascular smooth muscle cell differentiation by interfering with SRF binding to CArG box.43
198832642009The transcriptome of cervical ripening in human pregnancy before the onset of labor at term: identification of novel molecular functions involved in this process.34
172928252007Inactivation of myocardin and p16 during malignant transformation contributes to a differentiation defect.29
256142782015Myocardin regulates vascular smooth muscle cell inflammatory activation and disease.27

Citation

Dessen P

MYOCD (myocardin)

Atlas Genet Cytogenet Oncol Haematol. 2010-03-01

Online version: http://atlasgeneticsoncology.org/gene/51392/myocd