MZB1 (marginal zone B and B1 cell specific protein)

2010-12-01  

Identity

HGNC
LOCATION
5q31.2
LOCUSID
ALIAS
MEDA-7,PACAP,pERp1
FUSION GENES

Other Information

Locus ID:

NCBI: 51237
MIM: 609447
HGNC: 30125
Ensembl: ENSG00000170476

Variants:

dbSNP: 51237
ClinVar: 51237
TCGA: ENSG00000170476
COSMIC: MZB1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000170476ENST00000302125Q8WU39
ENSG00000170476ENST00000417694Q8WU39
ENSG00000170476ENST00000503351H0Y9L3
ENSG00000170476ENST00000503481Q8WU39
ENSG00000170476ENST00000513389D6RII0

Expression (GTEx)

0
50
100
150
200
250
300

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
240140232013Transgenic expression of microRNA-185 causes a developmental arrest of T cells by targeting multiple genes including Mzb1.17
225733532012Integrative array-based approach identifies MZB1 as a frequently methylated putative tumor suppressor in hepatocellular carcinoma.9
274595042016Epigenetic suppression of the immunoregulator MZB1 is associated with the malignant phenotype of gastric cancer.9
127927992003MGC29506 gene, frequently down-regulated in intestinal-type gastric cancer, encodes secreted-type protein with conserved cysteine residues.4
293823652018Increase of MZB1 in B cells in systemic lupus erythematosus: proteomic analysis of biopsied lymph nodes.3
226133352012[Proteomics-based identification of proapoptotic caspase adapter protein as a novel serum marker of non-small cell lung cancer].2
231899342013High expression of MZB1 predicts adverse prognosis in chronic lymphocytic leukemia, follicular lymphoma and diffuse large B-cell lymphoma and is associated with a unique gene expression signature.2
234344602013MGC29506 induces cell cycle arrest and is downregulated in gastric cancer.2
291802082017MZB1 in borderline resectable pancreatic cancer resected after neoadjuvant chemoradiotherapy.1

Citation

Dessen P

MZB1 (marginal zone B and B1 cell specific protein)

Atlas Genet Cytogenet Oncol Haematol. 2010-12-01

Online version: http://atlasgeneticsoncology.org/gene/51804/mzb1