N6AMT1 (N-6 adenine-specific DNA methyltransferase 1)

2017-10-01  

Identity

HGNC
LOCATION
21q21.3
LOCUSID
ALIAS
C21orf127,HEMK2,KMT9,MTQ2,N6AMT,PRED28,PrmC,m.HsaHemK2P

Other Information

Locus ID:

NCBI: 29104
MIM: 614553
HGNC: 16021
Ensembl: ENSG00000156239

Variants:

dbSNP: 29104
ClinVar: 29104
TCGA: ENSG00000156239
COSMIC: N6AMT1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000156239ENST00000303775Q9Y5N5
ENSG00000156239ENST00000351429Q9Y5N5
ENSG00000156239ENST00000460212Q9Y5N5

Expression (GTEx)

0
5
10
15
20
25

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
TranslationREACTOMER-HSA-72766
Eukaryotic Translation TerminationREACTOMER-HSA-72764
Gene ExpressionREACTOMER-HSA-74160
MetabolismREACTOMER-HSA-1430728
Biological oxidationsREACTOMER-HSA-211859
Phase II conjugationREACTOMER-HSA-156580
MethylationREACTOMER-HSA-156581

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA166129560major adverse cardiac events (mace)DiseaseClinicalAnnotationassociatedPKPD
PA449053clopidogrelChemicalClinicalAnnotationassociatedPKPD

References

Pubmed IDYearTitleCitations
300175832018N6-Methyladenine DNA Modification in the Human Genome.66
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
185391462008HemK2 protein, encoded on human chromosome 21, methylates translation termination factor eRF1.27
211933882011Involvement of N-6 adenine-specific DNA methyltransferase 1 (N6AMT1) in arsenic biomethylation and its role in arsenic-induced toxicity.26
236659092013N-6-adenine-specific DNA methyltransferase 1 (N6AMT1) polymorphisms and arsenic methylation in Andean women.11
310615262019KMT9 monomethylates histone H4 lysine 12 and controls proliferation of prostate cancer cells.9
276378982017Interactive Influence of N6AMT1 and As3MT Genetic Variations on Arsenic Metabolism in the Population of Inner Mongolia, China.8
286405052017Associations between arsenic (+3 oxidation state) methyltransferase (AS3MT) and N-6 adenine-specific DNA methyltransferase 1 (N6AMT1) polymorphisms, arsenic metabolism, and cancer risk in a chilean population.6

Citation

Dessen P

N6AMT1 (N-6 adenine-specific DNA methyltransferase 1)

Atlas Genet Cytogenet Oncol Haematol. 2017-10-01

Online version: http://atlasgeneticsoncology.org/gene/57077/n6amt1