NAA15 (N-alpha-acetyltransferase 15, NatA auxiliary subunit)

2010-02-01  

Identity

HGNC
NAA15
LOCATION
4q31.1
LOCUSID
80155
ALIAS
Ga19,MRD50,NARG1,NAT1P,NATH,TBDN,TBDN100
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 80155
MIM: 608000
HGNC: 30782
Ensembl: ENSG00000164134

Variants:

dbSNP: 80155
ClinVar: 80155
TCGA: ENSG00000164134
COSMIC: NAA15

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000164134ENST00000296543Q9BXJ9
ENSG00000164134ENST00000398947A0A0B4J1W3
ENSG00000164134ENST00000515576D6RAP7

Expression (GTEx)

0
5
10
15
20
25
30
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
154961422005Identification and characterization of the human ARD1-NATH protein acetyltransferase complex.66
154961422005Identification and characterization of the human ARD1-NATH protein acetyltransferase complex.66
154961422005Identification and characterization of the human ARD1-NATH protein acetyltransferase complex.66
165184072006Induction of apoptosis in human cells by RNAi-mediated knockdown of hARD1 and NATH, components of the protein N-alpha-acetyltransferase complex.43
201541452010The chaperone-like protein HYPK acts together with NatA in cotranslational N-terminal acetylation and prevention of Huntingtin aggregation.43
121407562002NATH, a novel gene overexpressed in papillary thyroid carcinomas.20
235576242013Design, synthesis, and kinetic characterization of protein N-terminal acetyltransferase inhibitors.18
162798462005Expression of N-acetyl transferase human and human Arrest defective 1 proteins in thyroid neoplasms.17
285855742017Structural basis of HypK regulating N-terminal acetylation by the NatA complex.11
297548252018Structure of Human NatA and Its Regulation by the Huntingtin Interacting Protein HYPK.10

Citation

Dessen P

NAA15 (N-alpha-acetyltransferase 15, NatA auxiliary subunit)

Atlas Genet Cytogenet Oncol Haematol. 2010-02-01

Online version: http://atlasgeneticsoncology.org/gene/51332/naa15