NAA50 (N-alpha-acetyltransferase 50, NatE catalytic subunit)

2014-08-01  

Identity

HGNC
LOCATION
3q13.31
LOCUSID
ALIAS
MAK3,NAT13,NAT13P,NAT5,NAT5P,SAN,hNaa50p
FUSION GENES

Other Information

Locus ID:

NCBI: 80218
MIM: 610834
HGNC: 29533
Ensembl: ENSG00000121579

Variants:

dbSNP: 80218
ClinVar: 80218
TCGA: ENSG00000121579
COSMIC: NAA50

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000121579ENST00000240922Q9GZZ1
ENSG00000121579ENST00000477813C9J5D1
ENSG00000121579ENST00000478020C9JZU6
ENSG00000121579ENST00000481432F8WCK0
ENSG00000121579ENST00000493454B0AZT5
ENSG00000121579ENST00000493900E7EQ69
ENSG00000121579ENST00000497255C9J5J3
ENSG00000121579ENST00000497525B0AZT5
ENSG00000121579ENST00000616174A0A087WWJ2
ENSG00000121579ENST00000630058A0A0D9SF32

Expression (GTEx)

0
10
20
30
40
50
60
70

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
193985762009Knockdown of human N alpha-terminal acetyltransferase complex C leads to p53-dependent apoptosis and aberrant human Arl8b localization.46
197449292009Human Naa50p (Nat5/San) displays both protein N alpha- and N epsilon-acetyltransferase activity.45
219002312011Structure of a ternary Naa50p (NAT5/SAN) N-terminal acetyltransferase complex reveals the molecular basis for substrate-specific acetylation.43
175024242007The acetyltransferase activity of San stabilizes the mitotic cohesin at the centromeres in a shugoshin-independent manner.34
165073392006Cloning and characterization of hNAT5/hSAN: an evolutionarily conserved component of the NatA protein N-alpha-acetyltransferase complex.29
235576242013Design, synthesis, and kinetic characterization of protein N-terminal acetyltransferase inhibitors.18
258861452015N-terminal acetylome analysis reveals the specificity of Naa50 (Nat5) and suggests a kinetic competition between N-terminal acetyltransferases and methionine aminopeptidases.17
223119702012Human protein N-terminal acetyltransferase hNaa50p (hNAT5/hSAN) follows ordered sequential catalytic mechanism: combined kinetic and NMR study.9
274228212016Opposing Functions of the N-terminal Acetyltransferases Naa50 and NatA in Sister-chromatid Cohesion.4
274847992016Human Naa50 Protein Displays Broad Substrate Specificity for Amino-terminal Acetylation: DETAILED STRUCTURAL AND BIOCHEMICAL ANALYSIS USING TETRAPEPTIDE LIBRARY.3

Citation

Dessen P

NAA50 (N-alpha-acetyltransferase 50, NatE catalytic subunit)

Atlas Genet Cytogenet Oncol Haematol. 2014-08-01

Online version: http://atlasgeneticsoncology.org/gene/54485/naa50