NAA60 (N-alpha-acetyltransferase 60, NatF catalytic subunit)

2016-10-01  

Identity

HGNC
LOCATION
16p13.3
LOCUSID
ALIAS
HAT4,NAT15,NatF,hNaa60
FUSION GENES

Other Information

Locus ID:

NCBI: 79903
MIM: 614246
HGNC: 25875
Ensembl: ENSG00000122390

Variants:

dbSNP: 79903
ClinVar: 79903
TCGA: ENSG00000122390
COSMIC: NAA60

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000122390ENST00000360862Q9H7X0
ENSG00000122390ENST00000407558Q9H7X0
ENSG00000122390ENST00000407558A0A384NYU5
ENSG00000122390ENST00000414063Q9H7X0
ENSG00000122390ENST00000414063A0A384NYU5
ENSG00000122390ENST00000421765Q9H7X0
ENSG00000122390ENST00000424546Q9H7X0
ENSG00000122390ENST00000570372I3L4T5
ENSG00000122390ENST00000570819Q9H7X0
ENSG00000122390ENST00000572131I3L2M6
ENSG00000122390ENST00000572169Q9H7X0
ENSG00000122390ENST00000572169A0A384NYU5
ENSG00000122390ENST00000572584Q9H7X0
ENSG00000122390ENST00000572584A0A384NYU5
ENSG00000122390ENST00000572739I3L4Q3
ENSG00000122390ENST00000572757I3L2K7
ENSG00000122390ENST00000572942Q9H7X0
ENSG00000122390ENST00000573345I3L1B9
ENSG00000122390ENST00000573580Q9H7X0
ENSG00000122390ENST00000573593I3L1T4
ENSG00000122390ENST00000574328I3L2B4
ENSG00000122390ENST00000574950I3L205
ENSG00000122390ENST00000575076Q9H7X0
ENSG00000122390ENST00000575076A0A384NYU5
ENSG00000122390ENST00000575733I3L4Q5
ENSG00000122390ENST00000576787I3L1X5
ENSG00000122390ENST00000576916I3L153
ENSG00000122390ENST00000577013Q9H7X0
ENSG00000122390ENST00000649205Q9H7X0
ENSG00000122390ENST00000649205A0A384NYU5
ENSG00000122390ENST00000649360Q9H7X0
ENSG00000122390ENST00000649360A0A384NYU5

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
50

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
217506862011NatF contributes to an evolutionary shift in protein N-terminal acetylation and is important for normal chromosome segregation.68
257328262015An organellar nα-acetyltransferase, naa60, acetylates cytosolic N termini of transmembrane proteins and maintains Golgi integrity.34
219819172011HAT4, a Golgi apparatus-anchored B-type histone acetyltransferase, acetylates free histone H4 and facilitates chromatin assembly.30
262882492015Variability of Gene Expression Identifies Transcriptional Regulators of Early Human Embryonic Development.17
273208342016Crystal Structure of the Golgi-Associated Human Nα-Acetyltransferase 60 Reveals the Molecular Determinants for Substrate-Specific Acetylation.16
281968612017Molecular determinants of the N-terminal acetyltransferase Naa60 anchoring to the Golgi membrane.10
275506392016Structure and function of human Naa60 (NatF), a Golgi-localized bi-functional acetyltransferase.6
261640782015Holding it together: Naa60 at the Golgi.1

Citation

Dessen P

NAA60 (N-alpha-acetyltransferase 60, NatF catalytic subunit)

Atlas Genet Cytogenet Oncol Haematol. 2016-10-01

Online version: http://atlasgeneticsoncology.org/gene/56297/naa60