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NAAA (N-acylethanolamine acid amidase)

Identity

Alias (NCBI)ASAHL
PLT
HGNC (Hugo) NAAA
HGNC Previous nameASAHL
HGNC Previous nameN-acylsphingosine amidohydrolase (acid ceramidase)-like
LocusID (NCBI) 27163
Atlas_Id 50702
Location 4q21.1  [Link to chromosome band 4q21]
Location_base_pair Starts at 75913661 and ends at 75941013 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
AHCTF1 (1q44) / NAAA (4q21.1)G3BP2 (4q21.1) / NAAA (4q21.1)NAAA (4q21.1) / NAAA (4q21.1)
PPBPP1 () / NAAA (4q21.1)G3BP2 4q21.1 / NAAA 4q21.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 2 ]
  t(1;4)(q44;q21) AHCTF1/NAAA
G3BP2/NAAA (4q21)


External links

Nomenclature
HGNC (Hugo)NAAA   736
Cards
Entrez_Gene (NCBI)NAAA  27163  N-acylethanolamine acid amidase
AliasesASAHL; PLT
GeneCards (Weizmann)NAAA
Ensembl hg19 (Hinxton)ENSG00000138744 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000138744 [Gene_View]  ENSG00000138744 [Sequence]  chr4:75913661-75941013 [Contig_View]  NAAA [Vega]
ICGC DataPortalENSG00000138744
TCGA cBioPortalNAAA
AceView (NCBI)NAAA
Genatlas (Paris)NAAA
WikiGenes27163
SOURCE (Princeton)NAAA
Genetics Home Reference (NIH)NAAA
Genomic and cartography
GoldenPath hg38 (UCSC)NAAA  -     chr4:75913661-75941013 -  4q21.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)NAAA  -     4q21.1   [Description]    (hg19-Feb_2009)
GoldenPathNAAA - 4q21.1 [CytoView hg19]  NAAA - 4q21.1 [CytoView hg38]
ImmunoBaseENSG00000138744
genome Data Viewer NCBINAAA [Mapview hg19]  
OMIM607469   
Gene and transcription
Genbank (Entrez)AB161353 AK024677 AK301132 AK309271 AV723847
RefSeq transcript (Entrez)NM_001042402 NM_001363719 NM_014435
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)NAAA
Alternative Splicing GalleryENSG00000138744
Gene ExpressionNAAA [ NCBI-GEO ]   NAAA [ EBI - ARRAY_EXPRESS ]   NAAA [ SEEK ]   NAAA [ MEM ]
Gene Expression Viewer (FireBrowse)NAAA [ Firebrowse - Broad ]
GenevisibleExpression of NAAA in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)27163
GTEX Portal (Tissue expression)NAAA
Human Protein AtlasENSG00000138744-NAAA [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ02083   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ02083  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ02083
Splice isoforms : SwissVarQ02083
PhosPhoSitePlusQ02083
Domains : Interpro (EBI)Acid_ceramidase-like    Acid_ceramidase_N    CBAH/NAAA_C   
Domain families : Pfam (Sanger)CBAH (PF02275)    NAAA-beta (PF15508)   
Domain families : Pfam (NCBI)pfam02275    pfam15508   
Conserved Domain (NCBI)NAAA
DMDM Disease mutations27163
Blocks (Seattle)NAAA
PDB (RSDB)6DXW    6DXX   
PDB Europe6DXW    6DXX   
PDB (PDBSum)6DXW    6DXX   
PDB (IMB)6DXW    6DXX   
Structural Biology KnowledgeBase6DXW    6DXX   
SCOP (Structural Classification of Proteins)6DXW    6DXX   
CATH (Classification of proteins structures)6DXW    6DXX   
SuperfamilyQ02083
Human Protein Atlas [tissue]ENSG00000138744-NAAA [tissue]
Peptide AtlasQ02083
HPRD12122
IPIIPI00024083   IPI00215844   IPI00028879   IPI00953184   IPI00963955   IPI00909751   
Protein Interaction databases
DIP (DOE-UCLA)Q02083
IntAct (EBI)Q02083
FunCoupENSG00000138744
BioGRIDNAAA
STRING (EMBL)NAAA
ZODIACNAAA
Ontologies - Pathways
QuickGOQ02083
Ontology : AmiGOcytoplasm  lysosome  fatty acid metabolic process  fatty acid metabolic process  neurotransmitter secretion  transcription factor binding  lipid catabolic process  hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds  hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds  fatty acid amide hydrolase activity  extrinsic component of membrane  lysosomal lumen  N-(long-chain-acyl)ethanolamine deacylase activity  extracellular exosome  N-acylethanolamine metabolic process  presynapse  
Ontology : EGO-EBIcytoplasm  lysosome  fatty acid metabolic process  fatty acid metabolic process  neurotransmitter secretion  transcription factor binding  lipid catabolic process  hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds  hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds  fatty acid amide hydrolase activity  extrinsic component of membrane  lysosomal lumen  N-(long-chain-acyl)ethanolamine deacylase activity  extracellular exosome  N-acylethanolamine metabolic process  presynapse  
NDEx NetworkNAAA
Atlas of Cancer Signalling NetworkNAAA
Wikipedia pathwaysNAAA
Orthology - Evolution
OrthoDB27163
GeneTree (enSembl)ENSG00000138744
Phylogenetic Trees/Animal Genes : TreeFamNAAA
HOGENOMQ02083
Homologs : HomoloGeneNAAA
Homology/Alignments : Family Browser (UCSC)NAAA
Gene fusions - Rearrangements
Fusion : MitelmanAHCTF1/NAAA [1q44/4q21.1]  
Fusion : MitelmanG3BP2/NAAA [4q21.1/4q21.1]  
Fusion PortalG3BP2 4q21.1 NAAA 4q21.1 LUAD
Fusion : QuiverNAAA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNAAA [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NAAA
dbVarNAAA
ClinVarNAAA
1000_GenomesNAAA 
Exome Variant ServerNAAA
GNOMAD BrowserENSG00000138744
Varsome BrowserNAAA
Genetic variants : HAPMAP27163
Genomic Variants (DGV)NAAA [DGVbeta]
DECIPHERNAAA [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisNAAA 
Mutations
ICGC Data PortalNAAA 
TCGA Data PortalNAAA 
Broad Tumor PortalNAAA
OASIS PortalNAAA [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICNAAA  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DNAAA
Mutations and Diseases : HGMDNAAA
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch NAAA
DgiDB (Drug Gene Interaction Database)NAAA
DoCM (Curated mutations)NAAA (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)NAAA (select a term)
intoGenNAAA
Cancer3DNAAA(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM607469   
Orphanet
DisGeNETNAAA
MedgenNAAA
Genetic Testing Registry NAAA
NextProtQ02083 [Medical]
TSGene27163
GENETestsNAAA
Target ValidationNAAA
Huge Navigator NAAA [HugePedia]
snp3D : Map Gene to Disease27163
BioCentury BCIQNAAA
ClinGenNAAA
Clinical trials, drugs, therapy
Protein Interactions : CTD27163
Pharm GKB GenePA162396672
Clinical trialNAAA
Miscellaneous
canSAR (ICR)NAAA (select the gene name)
HarmonizomeNAAA
DataMed IndexNAAA
Probes
Litterature
PubMed25 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineNAAA
EVEXNAAA
GoPubMedNAAA
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Jul 16 15:26:24 CEST 2020

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