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NAAA (N-acylethanolamine acid amidase)

Identity

Alias_namesASAHL
N-acylsphingosine amidohydrolase (acid ceramidase)-like
Other aliasPLT
HGNC (Hugo) NAAA
LocusID (NCBI) 27163
Atlas_Id 50702
Location 4q21.1  [Link to chromosome band 4q21]
Location_base_pair Starts at 76831808 and ends at 76862166 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
AHCTF1 (1q44) / NAAA (4q21.1)G3BP2 (4q21.1) / NAAA (4q21.1)NAAA (4q21.1) / NAAA (4q21.1)
PPBPP1 () / NAAA (4q21.1)G3BP2 4q21.1 / NAAA 4q21.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)NAAA   736
Cards
Entrez_Gene (NCBI)NAAA  27163  N-acylethanolamine acid amidase
AliasesASAHL; PLT
GeneCards (Weizmann)NAAA
Ensembl hg19 (Hinxton)ENSG00000138744 [Gene_View]  chr4:76831808-76862166 [Contig_View]  NAAA [Vega]
Ensembl hg38 (Hinxton)ENSG00000138744 [Gene_View]  chr4:76831808-76862166 [Contig_View]  NAAA [Vega]
ICGC DataPortalENSG00000138744
TCGA cBioPortalNAAA
AceView (NCBI)NAAA
Genatlas (Paris)NAAA
WikiGenes27163
SOURCE (Princeton)NAAA
Genetics Home Reference (NIH)NAAA
Genomic and cartography
GoldenPath hg19 (UCSC)NAAA  -     chr4:76831808-76862166 -  4q21.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)NAAA  -     4q21.1   [Description]    (hg38-Dec_2013)
EnsemblNAAA - 4q21.1 [CytoView hg19]  NAAA - 4q21.1 [CytoView hg38]
Mapping of homologs : NCBINAAA [Mapview hg19]  NAAA [Mapview hg38]
OMIM607469   
Gene and transcription
Genbank (Entrez)AB161353 AK024677 AK301132 AK309271 AV723847
RefSeq transcript (Entrez)NM_001042402 NM_014435
RefSeq genomic (Entrez)NC_000004 NC_018915 NT_016354 NW_004929320
Consensus coding sequences : CCDS (NCBI)NAAA
Cluster EST : UnigeneHs.437365 [ NCBI ]
CGAP (NCI)Hs.437365
Alternative Splicing GalleryENSG00000138744
Gene ExpressionNAAA [ NCBI-GEO ]   NAAA [ EBI - ARRAY_EXPRESS ]   NAAA [ SEEK ]   NAAA [ MEM ]
Gene Expression Viewer (FireBrowse)NAAA [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)27163
GTEX Portal (Tissue expression)NAAA
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ02083   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ02083  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ02083
Splice isoforms : SwissVarQ02083
Catalytic activity : Enzyme3.5.1.- [ Enzyme-Expasy ]   3.5.1.-3.5.1.- [ IntEnz-EBI ]   3.5.1.- [ BRENDA ]   3.5.1.- [ KEGG ]   
PhosPhoSitePlusQ02083
Domains : Interpro (EBI)Acid_ceramidase-like    Acid_ceramidase_N    CBAH/NAAA_C   
Domain families : Pfam (Sanger)CBAH (PF02275)    NAAA-beta (PF15508)   
Domain families : Pfam (NCBI)pfam02275    pfam15508   
Conserved Domain (NCBI)NAAA
DMDM Disease mutations27163
Blocks (Seattle)NAAA
SuperfamilyQ02083
Human Protein AtlasENSG00000138744
Peptide AtlasQ02083
HPRD12122
IPIIPI00024083   IPI00215844   IPI00028879   IPI00953184   IPI00963955   IPI00909751   
Protein Interaction databases
DIP (DOE-UCLA)Q02083
IntAct (EBI)Q02083
FunCoupENSG00000138744
BioGRIDNAAA
STRING (EMBL)NAAA
ZODIACNAAA
Ontologies - Pathways
QuickGOQ02083
Ontology : AmiGOcytoplasm  lipid metabolic process  neurotransmitter secretion  transcription factor binding  biological_process  hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds  hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds  lysosomal lumen  extracellular exosome  presynapse  
Ontology : EGO-EBIcytoplasm  lipid metabolic process  neurotransmitter secretion  transcription factor binding  biological_process  hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds  hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds  lysosomal lumen  extracellular exosome  presynapse  
NDEx NetworkNAAA
Atlas of Cancer Signalling NetworkNAAA
Wikipedia pathwaysNAAA
Orthology - Evolution
OrthoDB27163
GeneTree (enSembl)ENSG00000138744
Phylogenetic Trees/Animal Genes : TreeFamNAAA
HOVERGENQ02083
HOGENOMQ02083
Homologs : HomoloGeneNAAA
Homology/Alignments : Family Browser (UCSC)NAAA
Gene fusions - Rearrangements
Fusion : MitelmanAHCTF1/NAAA [1q44/4q21.1]  [t(1;4)(q44;q21)]  
Fusion : MitelmanG3BP2/NAAA [4q21.1/4q21.1]  [t(4;4)(q21;q21)]  
Fusion: TCGAG3BP2 4q21.1 NAAA 4q21.1 LUAD
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNAAA [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NAAA
dbVarNAAA
ClinVarNAAA
1000_GenomesNAAA 
Exome Variant ServerNAAA
ExAC (Exome Aggregation Consortium)NAAA (select the gene name)
Genetic variants : HAPMAP27163
Genomic Variants (DGV)NAAA [DGVbeta]
DECIPHER (Syndromes)4:76831808-76862166  ENSG00000138744
CONAN: Copy Number AnalysisNAAA 
Mutations
ICGC Data PortalNAAA 
TCGA Data PortalNAAA 
Broad Tumor PortalNAAA
OASIS PortalNAAA [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICNAAA  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDNAAA
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch NAAA
DgiDB (Drug Gene Interaction Database)NAAA
DoCM (Curated mutations)NAAA (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)NAAA (select a term)
intoGenNAAA
Cancer3DNAAA(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM607469   
Orphanet
MedgenNAAA
Genetic Testing Registry NAAA
NextProtQ02083 [Medical]
TSGene27163
GENETestsNAAA
Huge Navigator NAAA [HugePedia]
snp3D : Map Gene to Disease27163
BioCentury BCIQNAAA
ClinGenNAAA
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD27163
Chemical/Pharm GKB GenePA162396672
Clinical trialNAAA
Miscellaneous
canSAR (ICR)NAAA (select the gene name)
Probes
Litterature
PubMed20 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineNAAA
EVEXNAAA
GoPubMedNAAA
iHOPNAAA
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Mar 30 15:11:35 CEST 2017

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