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NAALAD2 (N-acetylated alpha-linked acidic dipeptidase 2)

Identity

Alias_symbol (synonym)NAALADASE2
GCPIII
Other aliasGPCIII
NAADALASE2
HGNC (Hugo) NAALAD2
LocusID (NCBI) 10003
Atlas_Id 41490
Location 11q14.3  [Link to chromosome band 11q14]
Location_base_pair Starts at 90134650 and ends at 90192611 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
GRIA4 (11q22.3) / NAALAD2 (11q14.3)SETD5 (3p25.3) / NAALAD2 (11q14.3)GRIA4 11q22.3 / NAALAD2 11q14.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)NAALAD2   14526
Cards
Entrez_Gene (NCBI)NAALAD2  10003  N-acetylated alpha-linked acidic dipeptidase 2
AliasesGCPIII; GPCIII; NAADALASE2; NAALADASE2
GeneCards (Weizmann)NAALAD2
Ensembl hg19 (Hinxton)ENSG00000077616 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000077616 [Gene_View]  chr11:90134650-90192611 [Contig_View]  NAALAD2 [Vega]
ICGC DataPortalENSG00000077616
TCGA cBioPortalNAALAD2
AceView (NCBI)NAALAD2
Genatlas (Paris)NAALAD2
WikiGenes10003
SOURCE (Princeton)NAALAD2
Genetics Home Reference (NIH)NAALAD2
Genomic and cartography
GoldenPath hg38 (UCSC)NAALAD2  -     chr11:90134650-90192611 +  11q14.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)NAALAD2  -     11q14.3   [Description]    (hg19-Feb_2009)
EnsemblNAALAD2 - 11q14.3 [CytoView hg19]  NAALAD2 - 11q14.3 [CytoView hg38]
Mapping of homologs : NCBINAALAD2 [Mapview hg19]  NAALAD2 [Mapview hg38]
OMIM611636   
Gene and transcription
Genbank (Entrez)AJ012370 AK075390 AL133614 AY010115 BC027594
RefSeq transcript (Entrez)NM_001300930 NM_005467
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)NAALAD2
Cluster EST : UnigeneHs.503560 [ NCBI ]
CGAP (NCI)Hs.503560
Alternative Splicing GalleryENSG00000077616
Gene ExpressionNAALAD2 [ NCBI-GEO ]   NAALAD2 [ EBI - ARRAY_EXPRESS ]   NAALAD2 [ SEEK ]   NAALAD2 [ MEM ]
Gene Expression Viewer (FireBrowse)NAALAD2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10003
GTEX Portal (Tissue expression)NAALAD2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9Y3Q0   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9Y3Q0  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9Y3Q0
Splice isoforms : SwissVarQ9Y3Q0
Catalytic activity : Enzyme3.4.17.21 [ Enzyme-Expasy ]   3.4.17.213.4.17.21 [ IntEnz-EBI ]   3.4.17.21 [ BRENDA ]   3.4.17.21 [ KEGG ]   
PhosPhoSitePlusQ9Y3Q0
Domains : Interpro (EBI)PA_domain    Peptidase_M28    TFR-like_dimer_dom   
Domain families : Pfam (Sanger)PA (PF02225)    Peptidase_M28 (PF04389)    TFR_dimer (PF04253)   
Domain families : Pfam (NCBI)pfam02225    pfam04389    pfam04253   
Conserved Domain (NCBI)NAALAD2
DMDM Disease mutations10003
Blocks (Seattle)NAALAD2
PDB (SRS)3FEC    3FED    3FEE    3FF3   
PDB (PDBSum)3FEC    3FED    3FEE    3FF3   
PDB (IMB)3FEC    3FED    3FEE    3FF3   
PDB (RSDB)3FEC    3FED    3FEE    3FF3   
Structural Biology KnowledgeBase3FEC    3FED    3FEE    3FF3   
SCOP (Structural Classification of Proteins)3FEC    3FED    3FEE    3FF3   
CATH (Classification of proteins structures)3FEC    3FED    3FEE    3FF3   
SuperfamilyQ9Y3Q0
Human Protein AtlasENSG00000077616
Peptide AtlasQ9Y3Q0
HPRD07494
IPIIPI00023151   IPI00745947   IPI00975610   IPI00979690   IPI00977674   IPI01008799   IPI00619927   IPI00978317   
Protein Interaction databases
DIP (DOE-UCLA)Q9Y3Q0
IntAct (EBI)Q9Y3Q0
FunCoupENSG00000077616
BioGRIDNAALAD2
STRING (EMBL)NAALAD2
ZODIACNAALAD2
Ontologies - Pathways
QuickGOQ9Y3Q0
Ontology : AmiGOcarboxypeptidase activity  plasma membrane  proteolysis  serine-type peptidase activity  metallopeptidase activity  dipeptidyl-peptidase activity  cellular amino acid biosynthetic process  integral component of membrane  dipeptidase activity  dipeptidase activity  neurotransmitter catabolic process  metal ion binding  N-formylglutamate deformylase activity  
Ontology : EGO-EBIcarboxypeptidase activity  plasma membrane  proteolysis  serine-type peptidase activity  metallopeptidase activity  dipeptidyl-peptidase activity  cellular amino acid biosynthetic process  integral component of membrane  dipeptidase activity  dipeptidase activity  neurotransmitter catabolic process  metal ion binding  N-formylglutamate deformylase activity  
NDEx NetworkNAALAD2
Atlas of Cancer Signalling NetworkNAALAD2
Wikipedia pathwaysNAALAD2
Orthology - Evolution
OrthoDB10003
GeneTree (enSembl)ENSG00000077616
Phylogenetic Trees/Animal Genes : TreeFamNAALAD2
HOVERGENQ9Y3Q0
HOGENOMQ9Y3Q0
Homologs : HomoloGeneNAALAD2
Homology/Alignments : Family Browser (UCSC)NAALAD2
Gene fusions - Rearrangements
Fusion : MitelmanGRIA4/NAALAD2 [11q22.3/11q14.3]  [t(11;11)(q14;q22)]  
Fusion: TCGAGRIA4 11q22.3 NAALAD2 11q14.3 LGG
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNAALAD2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NAALAD2
dbVarNAALAD2
ClinVarNAALAD2
1000_GenomesNAALAD2 
Exome Variant ServerNAALAD2
ExAC (Exome Aggregation Consortium)NAALAD2 (select the gene name)
Genetic variants : HAPMAP10003
Genomic Variants (DGV)NAALAD2 [DGVbeta]
DECIPHERNAALAD2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisNAALAD2 
Mutations
ICGC Data PortalNAALAD2 
TCGA Data PortalNAALAD2 
Broad Tumor PortalNAALAD2
OASIS PortalNAALAD2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICNAALAD2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDNAALAD2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch NAALAD2
DgiDB (Drug Gene Interaction Database)NAALAD2
DoCM (Curated mutations)NAALAD2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)NAALAD2 (select a term)
intoGenNAALAD2
Cancer3DNAALAD2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM611636   
Orphanet
MedgenNAALAD2
Genetic Testing Registry NAALAD2
NextProtQ9Y3Q0 [Medical]
TSGene10003
GENETestsNAALAD2
Target ValidationNAALAD2
Huge Navigator NAALAD2 [HugePedia]
snp3D : Map Gene to Disease10003
BioCentury BCIQNAALAD2
ClinGenNAALAD2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD10003
Chemical/Pharm GKB GenePA31430
Clinical trialNAALAD2
Miscellaneous
canSAR (ICR)NAALAD2 (select the gene name)
Probes
Litterature
PubMed11 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineNAALAD2
EVEXNAALAD2
GoPubMedNAALAD2
iHOPNAALAD2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 12:46:00 CEST 2017

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